Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HRH4 | Q9H3N8 | 1/20 | 0.45 |
| ▸ | NOS1 | P29475 | 5/20 | 0.44 |
| ▸ | NOS3 | P29474 | 4/20 | 0.44 |
| ▸ | HRH3 | Q9Y5N1 | 1/20 | 0.43 |
| ▸ | KIT | P10721 | 4/20 | 0.41 |
| ▸ | FLT3 | P36888 | 4/20 | 0.41 |
| ▸ | DRD2 | P14416 | 2/20 | 0.40 |
| ▸ | HTR2A | P28223 | 2/20 | 0.40 |
| ▸ | HTR1A | P08908 | 1/20 | 0.40 |
| ▸ | ASIC3 | Q9UHC3 | 1/20 | 0.40 |
| ▸ | RAD52 | P43351 | 2/20 | 0.39 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.39 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.39 |
| ▸ | GAA | P10253 | 1/20 | 0.39 |
| ▸ | MAPT | P10636 | 1/20 | 0.39 |
| ▸ | GFER | P55789 | 1/20 | 0.39 |
| ▸ | CYP2D6 | P10635 | 2/20 | 0.39 |
| ▸ | CNR1 | P21554 | 1/20 | 0.39 |
| ▸ | CNR2 | P34972 | 1/20 | 0.39 |
| ▸ | NTRK1 | P04629 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL902069 | 0.85 | HRH4 (0.57) | HRH4HRH3 | |
| SCHEMBL12469600 | 0.85 | KARS1 (0.45) | NOS1NOS3HRH3KITFLT3 | |
| SCHEMBL24322998 | 0.82 | HRH3 (0.56) | HRH3RAD52SMN1; SMN2KDM4EGAA | |
| SCHEMBL902018 | 0.80 | NCF1 (0.52) | HRH4NOS1NOS3GFERCNR2 | |
| SCHEMBL5452265 | 0.71 | DRD2 (0.50) | HRH3DRD2KDM4E | |
| SCHEMBL902067 | 0.70 | MTOR (0.54) | HRH4HRH3RAD52KDM4E | |
| SCHEMBL10112451 | 0.69 | HRH3 (0.49) | HRH3DRD2HTR2AHTR1ASMN1; SMN2 | |
| SCHEMBL3450414 | 0.68 | HPGD (0.67) | HRH4HRH3SMN1; SMN2KDM4EGAA | |
| SCHEMBL3869622 | 0.68 | HTR7 (0.47) | HRH3DRD2SMN1; SMN2KDM4EMAPT | |
| SCHEMBL22650478 | 0.67 | CXCR4 (0.49) | NOS1NOS3HRH3RAD52SMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2012041476-A1 | PYRIDINE AND ISOQUINOLINE DERIVATIVES AS SYK- AND JAK-KINASE INHIBITORS | ALMIRALL, S.A. (ES) | 2012-04-05 | — | — | WO | disclosed |