Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MTOR | P42345 | 1/20 | 0.54 |
| ▸ | SMG1 | Q96Q15 | 1/20 | 0.54 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.51 |
| ▸ | RAD52 | P43351 | 1/20 | 0.51 |
| ▸ | UBE2N | P61088 | 1/20 | 0.51 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.51 |
| ▸ | HRH4 | Q9H3N8 | 4/20 | 0.50 |
| ▸ | HRH3 | Q9Y5N1 | 1/20 | 0.50 |
| ▸ | KARS1 | Q15046 | 2/20 | 0.47 |
| ▸ | ROCK2 | O75116 | 1/20 | 0.47 |
| ▸ | ROCK1 | Q13464 | 1/20 | 0.47 |
| ▸ | HTR3A | P46098 | 2/20 | 0.47 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL12469600 | 0.86 | KARS1 (0.45) | MTORSMG1RAD52HRH3KARS1 | |
| SCHEMBL23901371 | 0.84 | MTOR (0.52) | MTORSMG1KDM4ERAD52UBE2N | |
| SCHEMBL902015 | 0.84 | ITGB2 (0.46) | MTORSMG1KARS1 | |
| SCHEMBL902069 | 0.84 | HRH4 (0.57) | HRH4HRH3HTR3A | |
| SCHEMBL901638 | 0.83 | PRKD3 (0.43) | MTORSMG1KDM4EL3MBTL1KARS1 | |
| SCHEMBL1704599 | 0.79 | CKS1B (0.51) | — | |
| SCHEMBL11906929 | 0.78 | HDAC2 (0.48) | MTORSMG1KDM4ERAD52UBE2N | |
| SCHEMBL2386000 | 0.77 | RIPK3 (0.53) | KDM4ERAD52UBE2NL3MBTL1HRH4 | |
| SCHEMBL2385606 | 0.76 | HRH4 (0.58) | KDM4ERAD52UBE2NL3MBTL1HRH4 | |
| SCHEMBL1704214 | 0.76 | KARS1 (0.77) | MTORSMG1KARS1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2441755-A1 | Pyridine- and isoquinoline-derivatives as Syk and JAK kinase inhibitors | Almirall, S.A. (ES) | 2012-04-18 | — | — | EP | disclosed |
| WO-2012041476-A1 | PYRIDINE AND ISOQUINOLINE DERIVATIVES AS SYK- AND JAK-KINASE INHIBITORS | ALMIRALL, S.A. (ES) | 2012-04-05 | — | — | WO | disclosed |