Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PSIP1 | O75475 | 1/20 | 0.39 |
| ▸ | PSEN1 | P49768 | 1/20 | 0.33 |
| ▸ | PSEN2 | P49810 | 1/20 | 0.33 |
| ▸ | APH1B | Q8WW43 | 1/20 | 0.33 |
| ▸ | NCSTN | Q92542 | 1/20 | 0.33 |
| ▸ | APH1A | Q96BI3 | 1/20 | 0.33 |
| ▸ | PSENEN | Q9NZ42 | 1/20 | 0.33 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.31 |
| ▸ | MAP2K1 | Q02750 | 1/20 | 0.31 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.31 |
| ▸ | LMNA | P02545 | 1/20 | 0.30 |
| ▸ | BRAF | P15056 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5015645 | 0.78 | KEAP1 (0.46) | PSIP1 | |
| SCHEMBL27872650 | 0.68 | — | — | |
| SCHEMBL9660227 | 0.68 | MCOLN3 (0.53) | CYP2C9ALDH1A1LMNA | |
| SCHEMBL27972747 | 0.67 | LMNA (0.41) | PSIP1ALDH1A1LMNA | |
| SCHEMBL10533917 | 0.65 | KEAP1 (0.54) | PSIP1PSEN1PSEN2APH1BNCSTN | |
| SCHEMBL5475470 | 0.65 | ALDH1A1 (0.48) | CYP2C9ALDH1A1LMNA | |
| SCHEMBL5012855 | 0.65 | KEAP1 (0.42) | CYP2C9 | |
| SCHEMBL455634 | 0.64 | — | — | |
| SCHEMBL9509351 | 0.64 | PSIP1 (0.51) | PSIP1ALDH1A1LMNA | |
| SCHEMBL9750102 | 0.63 | PSEN1 (0.42) | PSIP1PSEN1PSEN2APH1BNCSTN |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2672967-A1 | COMPOUNDS AND METHODS FOR KINASE MODULATION, AND INDICATIONS THEREFOR | Plexxikon, Inc. (US) | 2013-12-18 | — | — | EP | disclosed |
| WO-2012109075-A1 | COMPOUNDS AND METHODS FOR KINASE MODULATION, AND INDICATIONS THEREFOR | PLEXXIKON INC. (US) | 2012-08-16 | — | — | WO | disclosed |