Predicted protein targets (top 7)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CTSA | P10619 | 6/20 | 0.38 |
| ▸ | GPBAR1 | Q8TDU6 | 6/20 | 0.37 |
| ▸ | PPARD | Q03181 | 2/20 | 0.37 |
| ▸ | SCN9A | Q15858 | 1/20 | 0.37 |
| ▸ | MDM2 | Q00987 | 2/20 | 0.36 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.36 |
| ▸ | MAPT | P10636 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3707320 | 0.89 | CTSA (0.38) | CTSAPPARDMDM2 | |
| SCHEMBL1246303 | 0.88 | PPARD (0.46) | GPBAR1PPARDALDH1A1MAPT | |
| SCHEMBL1247108 | 0.85 | SCN9A (0.40) | GPBAR1PPARDSCN9A | |
| SCHEMBL1246467 | 0.85 | NR1H4 (0.43) | GPBAR1PPARDSCN9A | |
| SCHEMBL3706374 | 0.83 | MDM2 (0.39) | CTSAPPARDMDM2 | |
| SCHEMBL1246307 | 0.82 | NR1H4 (0.44) | GPBAR1PPARDSCN9AMAPT | |
| SCHEMBL1245358 | 0.81 | NR1H4 (0.42) | GPBAR1PPARDSCN9AALDH1A1MAPT | |
| SCHEMBL1247748 | 0.81 | SCN9A (0.39) | GPBAR1PPARDSCN9AALDH1A1MAPT | |
| SCHEMBL1246951 | 0.81 | CYP11B1 (0.40) | GPBAR1SCN9AALDH1A1MAPT | |
| SCHEMBL1246462 | 0.81 | GPBAR1 (0.42) | GPBAR1ALDH1A1MAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2462128-A2 | COMPOUNDS AS LYSOPHOSPHATIDIC ACID RECEPTOR ANTAGONISTS | Amira Pharmaceuticals, Inc. (US) | 2012-06-13 | — | — | EP | claimed |
| WO-2011017350-A2 | COMPOUNDS AS LYSOPHOSPHATIDIC ACID RECEPTOR ANTAGONISTS | AMIRA PHARMACEUTICALS, INC. (US) | 2011-02-10 | — | — | WO | claimed |