Known targets — ChEMBL curated mechanism
AGTR1DHFRGABBR1GABBR2GABRA1GABRA2GABRA3GABRA4GABRA5GABRA6GABRB1GABRB2GABRB3GABRDGABREGABRG1GABRG2GABRG3GABRPGABRQGARTNR3C2PBP2XPTGS1PTGS2VKORC1blablaT-3blaT-4blaT-5blaT-6dacAdacBdacCfolAftsImrcAmrcBmrdApbp1apbp1bpbp2apbp2bpbp3polthyA
The experimentally established mechanism targets of Potassium Ion. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TSHR | P16473 | 4/20 | 0.59 |
| ▸ | HPGD | P15428 | 3/20 | 0.59 |
| ▸ | RECQL | P46063 | 2/20 | 0.59 |
| ▸ | GLA | P06280 | 1/20 | 0.59 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.59 |
| ▸ | EPHX2 | P34913 | 1/20 | 0.59 |
| ▸ | BLM | P54132 | 1/20 | 0.59 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.45 |
| ▸ | CA1 | P00915 | 10/20 | 0.43 |
| ▸ | CA2 | P00918 | 10/20 | 0.43 |
| ▸ | CA9 | Q16790 | 8/20 | 0.38 |
| ▸ | MEN1 | O00255 | 1/20 | 0.38 |
| ▸ | THRB | P10828 | 1/20 | 0.38 |
| ▸ | HTT | P42858 | 1/20 | 0.38 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.38 |
| ▸ | MAPT | P10636 | 1/20 | 0.38 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.37 |
| ▸ | CA12 | O43570 | 3/20 | 0.36 |
| ▸ | CA7 | P43166 | 3/20 | 0.36 |
| ▸ | CA14 | Q9ULX7 | 3/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9186645 | 0.96 | TSHR (0.59) | TSHRHPGDRECQLGLAMAPK1 | |
| SCHEMBL6817543 | 0.96 | TSHR (0.64) | TSHRHPGDRECQLGLAMAPK1 | |
| Lithium Ion SCHEMBL17456604 | 0.96 | TSHR (0.59) | TSHRHPGDRECQLGLAMAPK1 | |
| Potassium Ion SCHEMBL819036 | 0.92 | RECQL (0.71) | TSHRHPGDRECQLGLAMAPK1 | |
| Potassium Ion SCHEMBL29371821 | 0.92 | RECQL (0.71) | TSHRHPGDRECQLGLAMAPK1 | |
| Potassium Ion SCHEMBL816807 | 0.92 | RECQL (0.71) | TSHRHPGDRECQLGLAMAPK1 | |
| Potassium Ion SCHEMBL5513988 | 0.92 | RECQL (0.71) | TSHRHPGDRECQLGLAMAPK1 | |
| Potassium Ion SCHEMBL29375108 | 0.92 | RECQL (0.71) | TSHRHPGDRECQLGLAMAPK1 | |
| Potassium Ion SCHEMBL1352916 | 0.92 | RECQL (0.71) | TSHRHPGDRECQLGLAMAPK1 | |
| SCHEMBL2568777 | 0.90 | TSHR (0.74) | TSHRHPGDRECQLGLAMAPK1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2012114342-A1 | FLUMAZENIL COMPLEXES, COMPOSITIONS COMPRISING SAME AND USES THEREOF | COERULEUS LTD. (IL) | 2012-08-30 | — | — | WO | claimed |
| US-9585893-B2 | Flumazenil complexes, compositions comprising same and uses thereof | COERULEUS LTD. (IL) | 2017-03-07 | — | — | US | disclosed |
| US-20130345202-A1 | Flumazenil Complexes, Compositions Comprising Same And Uses Thereof | COERULEUS LTD. (IL) | 2013-12-26 | — | — | US | disclosed |
| WO-2012114342-A1 | FLUMAZENIL COMPLEXES, COMPOSITIONS COMPRISING SAME AND USES THEREOF | COERULEUS LTD. (IL) | 2012-08-30 | — | — | WO | disclosed |