Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NPSR1 | Q6W5P4 | 2/20 | 0.54 |
| ▸ | HCAR2 | Q8TDS4 | 1/20 | 0.45 |
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.44 |
| ▸ | LMNA | P02545 | 2/20 | 0.44 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.44 |
| ▸ | MAPT | P10636 | 4/20 | 0.41 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.40 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.40 |
| ▸ | MEN1 | O00255 | 1/20 | 0.40 |
| ▸ | ATM | Q13315 | 1/20 | 0.40 |
| ▸ | GLO1 | Q04760 | 1/20 | 0.39 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.37 |
| ▸ | MGAM | O43451 | 1/20 | 0.37 |
| ▸ | GAA | P10253 | 1/20 | 0.37 |
| ▸ | SI | P14410 | 1/20 | 0.37 |
| ▸ | MGAM2 | Q2M2H8 | 1/20 | 0.37 |
| ▸ | SOAT1 | P35610 | 1/20 | 0.37 |
| ▸ | CA12 | O43570 | 1/20 | 0.35 |
| ▸ | CA1 | P00915 | 1/20 | 0.35 |
| ▸ | CA2 | P00918 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1248607 | 1.00 | NPSR1 (0.54) | NPSR1HCAR2ALDH1A1LMNAHSD17B10 | |
| SCHEMBL7552831 | 1.00 | NPSR1 (0.54) | NPSR1HCAR2ALDH1A1LMNAHSD17B10 | |
| SCHEMBL11168141 | 0.83 | NPSR1 (0.43) | NPSR1HCAR2ALDH1A1LMNAHSD17B10 | |
| SCHEMBL8778884 | 0.83 | NPSR1 (0.43) | NPSR1HCAR2ALDH1A1LMNAHSD17B10 | |
| SCHEMBL8778882 | 0.83 | NPSR1 (0.43) | NPSR1HCAR2ALDH1A1LMNAHSD17B10 | |
| SCHEMBL10959675 | 0.83 | NPSR1 (0.43) | NPSR1HCAR2ALDH1A1LMNAHSD17B10 | |
| SCHEMBL9666690 | 0.83 | NPSR1 (0.43) | NPSR1HCAR2ALDH1A1LMNAHSD17B10 | |
| SCHEMBL6023236 | 0.80 | NPSR1 (0.52) | NPSR1HCAR2ALDH1A1LMNAHSD17B10 | |
| SCHEMBL6023238 | 0.80 | NPSR1 (0.52) | NPSR1HCAR2ALDH1A1LMNAHSD17B10 | |
| SCHEMBL9517913 | 0.79 | ATM (0.59) | NPSR1HCAR2ALDH1A1LMNAMAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 76 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0371264-A2 | Phosphonate reagent compositions and methods of making same | LOYOLA UNIVERSITY OF CHICAGO (US) | 1990-06-06 | — | — | EP | claimed |
| US-11116212-B2 | Carbonyl containing compounds for controlling and repelling Cimicidae populations | SEMIOSBIO TECHNOLOGIES INC. (CA) | 2021-09-14 | — | — | US | disclosed |
| US-8889660-B2 | Methods for treating obesity or an obesity related condition | CASE WESTERN RESERVE UNIVERSITY (US) | 2014-11-18 | — | — | US | disclosed |
| US-20130072555-A1 | COMPOSITIONS AND METHODS FOR TREATING METABOLIC DISEASES | CASE WESTERN RESERVE UNIVERSITY (US) | 2013-03-21 | — | — | US | disclosed |
| US-20130006003-A1 | NEW SYNTHONES FOR PREPARATION OF 19-NOR VITAMIN D DERIVATIVES | INSTYTUT FARMACEUTYCZNY (PL) | 2013-01-03 | — | — | US | disclosed |
| US-8338394-B2 | Methods for treating metabolic diseases | CASE WESTERN RESERVE UNIVERSITY (US) | 2012-12-25 | — | — | US | disclosed |
| EP-2462113-A2 | NEW SYNTHONES FOR PREPARATION OF 19-NOR VITAMIN D DERIVATIVES | Instytut Farmaceutyczny (PL) | 2012-06-13 | — | — | EP | disclosed |
| EP-2323988-A1 | ALPHA7 NICOTINIC ACETYLCHOLINE RECEPTOR INHIBITORS | Wyeth LLC (US) | 2011-05-25 | — | — | EP | disclosed |
| WO-2011016739-A2 | NEW SYNTHONES FOR PREPARATION OF 19-NOR VITAMIN D DERIVATIVES | INSTYTUT FARMACEUTYCZNY (PL) | 2011-02-10 | — | — | WO | disclosed |
| EP-1546083-B1 | NOVEL SUBSTITUTED ARYLHEXADIENOIC ACIDS AND ESTERS THEREOF WHICH CAN BE USED FOR THE TREATMENT AND PREVENTION OF DIABETES, DYSLIPIDAEMIA AND ATHEROSCLEROSIS, PHARMACEUTICAL COMPOSITIONS COMPRISING THEM AND PROCESSES FOR THE PREPARATION OF THEM | MERCK PATENT GMBH (DE) | 2010-08-11 | — | — | EP | disclosed |
| US-4267382-A | ANTITUMOR AGENTS; SKIN DISORDERS | HOFFMANN-LA ROCHE INC. (US) | 1981-05-12 | — | — | US | disclosed |
| US-4225527-A | TREATMENT OF DERMATOLOGICAL CONDITIONS | HOFFMANN-LA ROCHE INC. (US) | 1980-09-30 | — | — | US | disclosed |
| US-4224244-A | ANTITUMOR AGENTS | HOFFMANN-LA ROCHE INC. (US) | 1980-09-23 | — | — | US | disclosed |
| US-4215215-A | 9-Phenyl-nonate traene compounds | HOFFMANN-LA ROCHE INC. (US) | 1980-07-29 | — | — | US | disclosed |
| US-4187247-A | ANTITUMOR AGENTS | HOFFMANN-LA ROCHE INC. (US) | 1980-02-05 | — | — | US | disclosed |
| US-4163103-A | ANTITUMOR AGENTS | HOFFMANN-LA ROCHE INC. (US) | 1979-07-31 | — | — | US | disclosed |
| US-4107190-A | ANTITUMOR | HOFFMANN-LA ROCHE INC. (US) | 1978-08-15 | — | — | US | disclosed |
| US-4105681-A | ANTITUMOR AGENTS | HOFFMANN-LA ROCHE INC. (US) | 1978-08-08 | — | — | US | disclosed |
| US-4054589-A | ANTITUMOR AGENTS | HOFFMANN-LA ROCHE INC. (US) | 1977-10-18 | — | — | US | disclosed |
| US-3984440-A | FOR NEOPLASIAS, DERMATOSES, INFLAMMATION AND ALLERGIES | HOFFMANN-LA ROCHE INC. (US) | 1976-10-05 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (3 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20130072555-A1 | COMPOSITIONS AND METHODS FOR TREATING METABOLIC DISEASES | GPR119, CYP27A1, HSD17B13 | NPSR1 1587/4885HCAR2 338/4885ALDH1A1 480/4885 |
| US-20130006003-A1 | NEW SYNTHONES FOR PREPARATION OF 19-NOR VITAMIN D DERIVATIVES | CYP24A1, CYP2R1, VDR | NPSR1 424/4885HCAR2 257/4885ALDH1A1 2186/4885 |
| US-11116212-B2 | Carbonyl containing compounds for controlling and repelling Cimicidae populations | DDT, AOC1, EGLN1 | NPSR1 3408/4885HCAR2 2072/4885ALDH1A1 250/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.