Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CYP19A1 | P11511 | 4/20 | 0.38 |
| ▸ | SIGMAR1 | Q99720 | 2/20 | 0.36 |
| ▸ | KDM4E | B2RXH2 | 4/20 | 0.36 |
| ▸ | TSHR | P16473 | 1/20 | 0.36 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.36 |
| ▸ | F2 | P00734 | 1/20 | 0.35 |
| ▸ | PLG | P00747 | 1/20 | 0.35 |
| ▸ | ELANE | P08246 | 1/20 | 0.35 |
| ▸ | CTSG | P08311 | 1/20 | 0.35 |
| ▸ | CMA1 | P23946 | 1/20 | 0.35 |
| ▸ | CTRC | Q99895 | 1/20 | 0.35 |
| ▸ | DAO | P14920 | 1/20 | 0.35 |
| ▸ | POLB | P06746 | 2/20 | 0.34 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.34 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.34 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.34 |
| ▸ | MAPT | P10636 | 1/20 | 0.34 |
| ▸ | CYP11B1 | P15538 | 1/20 | 0.34 |
| ▸ | CYP11B2 | P19099 | 1/20 | 0.34 |
| ▸ | TBXAS1 | P24557 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8894887 | 0.69 | SIGMAR1 (0.39) | CYP19A1SIGMAR1KDM4EF2PLG | |
| SCHEMBL4564191 | 0.68 | — | — | |
| SCHEMBL30445901 | 0.63 | CYP19A1 (0.38) | CYP19A1SIGMAR1KDM4ETSHRNPSR1 | |
| SCHEMBL5668043 | 0.63 | SIGMAR1 (0.41) | CYP19A1SIGMAR1KDM4ETSHRNPSR1 | |
| SCHEMBL5011455 | 0.62 | CALM1 (0.34) | CYP19A1SIGMAR1KDM4ETSHRNPSR1 | |
| SCHEMBL28795504 | 0.62 | ALDH1A1 (0.39) | CYP19A1SIGMAR1KDM4EF2PLG | |
| SCHEMBL7883589 | 0.62 | SIGMAR1 (0.39) | CYP19A1SIGMAR1KDM4ETSHRF2 | |
| SCHEMBL1085421 | 0.62 | SIGMAR1 (0.39) | CYP19A1SIGMAR1KDM4EF2PLG | |
| SCHEMBL5342697 | 0.60 | CYP19A1 (0.39) | CYP19A1SIGMAR1KDM4ETSHRNPSR1 | |
| SCHEMBL10756978 | 0.60 | CYP19A1 (0.39) | CYP19A1SIGMAR1KDM4EF2PLG |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2464353-B1 | TRIAZINE DERIVATIVES FOR USE IN THE TREATMENT OF MALARIA | CSIR (ZA) | 2017-03-29 | — | — | EP | disclosed |
| US-8940892-B2 | Triazine derivatives for use in the treatment of malaria | CSIR (ZA) | 2015-01-27 | — | — | US | disclosed |
| EP-2464353-A1 | TRIAZINE DERIVATES FOR USE IN THE TREATMENT OF MALARIA | CSIR (ZA) | 2012-06-20 | — | — | EP | disclosed |
| US-20120142920-A1 | TRIAZINE DERIVATIVES FOR USE IN THE TREATMENT OF MALARIA | CSIR (ZA) | 2012-06-07 | — | — | US | disclosed |
| WO-2011018742-A1 | TRIAZINE DERIVATES FOR USE IN THE TREATMENT OF MALARIA | CSIR (ZA) | 2011-02-17 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20120142920-A1 | TRIAZINE DERIVATIVES FOR USE IN THE TREATMENT OF MALARIA | CYP3A7, CCR7, CYP3A5 | CYP19A1 915/4885SIGMAR1 430/4885KDM4E 2423/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.