Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CALM1 | P0DP23 | 1/20 | 0.34 |
| ▸ | CYP19A1 | P11511 | 4/20 | 0.34 |
| ▸ | DHFR | P00374 | 1/20 | 0.34 |
| ▸ | LMNA | P02545 | 2/20 | 0.33 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.33 |
| ▸ | TSHR | P16473 | 1/20 | 0.33 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.33 |
| ▸ | SIGMAR1 | Q99720 | 1/20 | 0.32 |
| ▸ | NSD2 | O96028 | 1/20 | 0.32 |
| ▸ | HPGD | P15428 | 1/20 | 0.32 |
| ▸ | IDO1 | P14902 | 2/20 | 0.32 |
| ▸ | CYP11B1 | P15538 | 2/20 | 0.32 |
| ▸ | CYP11B2 | P19099 | 2/20 | 0.32 |
| ▸ | F2 | P00734 | 1/20 | 0.32 |
| ▸ | PLG | P00747 | 1/20 | 0.32 |
| ▸ | ELANE | P08246 | 1/20 | 0.32 |
| ▸ | CTSG | P08311 | 1/20 | 0.32 |
| ▸ | CMA1 | P23946 | 1/20 | 0.32 |
| ▸ | CTRC | Q99895 | 1/20 | 0.32 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL30445901 | 0.66 | CYP19A1 (0.38) | CYP19A1KDM4ETSHRNPSR1SIGMAR1 | |
| SCHEMBL1249231 | 0.62 | CYP19A1 (0.38) | CYP19A1KDM4ETSHRNPSR1SIGMAR1 | |
| SCHEMBL1078286 | 0.62 | SIGMAR1 (0.48) | CALM1CYP19A1LMNAKDM4ESIGMAR1 | |
| Hydrochloric Acid SCHEMBL9365933 | 0.62 | CYP19A1 (0.32) | CYP19A1LMNAKDM4ETSHRNPSR1 | |
| SCHEMBL5668043 | 0.59 | SIGMAR1 (0.41) | CYP19A1LMNAKDM4ETSHRNPSR1 | |
| Hydrochloric Acid SCHEMBL29906145 | 0.59 | GSK3A (0.37) | CYP19A1DHFRLMNAKDM4ESIGMAR1 | |
| SCHEMBL9030241 | 0.58 | P2RX4 (0.37) | CYP19A1DHFRLMNASIGMAR1NSD2 | |
| Diphenylmethane SCHEMBL1303 | 0.57 | CALM1 (1.00) | CALM1LMNAKDM4ETSHRHPGD | |
| Diphenylmethane SCHEMBL3792579 | 0.57 | CALM1 (1.00) | CALM1LMNAKDM4ETSHRHPGD | |
| Diphenylmethane SCHEMBL4361124 | 0.57 | CALM1 (1.00) | CALM1LMNAKDM4ETSHRHPGD |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1989188-A1 | THERAPEUTIC PIPERAZINES AS PDE4 INHIBITORS | Helicon Therapeutics, Inc. (US) | 2008-11-12 | — | — | EP | disclosed |
| WO-2007100852-A1 | THERAPEUTIC PIPERAZINES AS PDE4 INHIBITORS | HELICON THERAPEUTICS, INC. (US) | 2007-09-07 | — | — | WO | disclosed |