Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | APLNR | P35414 | 1/20 | 0.52 |
| ▸ | TP53 | P04637 | 1/20 | 0.51 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.47 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.47 |
| ▸ | PTK2B | Q14289 | 1/20 | 0.47 |
| ▸ | HTR2A | P28223 | 1/20 | 0.46 |
| ▸ | HTR2C | P28335 | 1/20 | 0.46 |
| ▸ | HDAC3 | O15379 | 1/20 | 0.46 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.46 |
| ▸ | HDAC2 | Q92769 | 1/20 | 0.46 |
| ▸ | HDAC8 | Q9BY41 | 1/20 | 0.46 |
| ▸ | MEN1 | O00255 | 4/20 | 0.45 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.45 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.44 |
| ▸ | GAA | P10253 | 2/20 | 0.43 |
| ▸ | NPC1 | O15118 | 1/20 | 0.43 |
| ▸ | MAPT | P10636 | 1/20 | 0.43 |
| ▸ | RAB9A | P51151 | 1/20 | 0.43 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL12493456 | 0.89 | MMP8 (0.50) | APLNRTP53HTR2AHTR2CHDAC3 | |
| SCHEMBL12494088 | 0.87 | APLNR (0.52) | APLNRTP53ALDH1A1MAPK1PTK2B | |
| SCHEMBL12494016 | 0.87 | ALDH1A1 (0.62) | APLNRTP53ALDH1A1MAPK1PTK2B | |
| SCHEMBL12494013 | 0.86 | SMN1; SMN2 (0.50) | APLNRTP53ALDH1A1MAPK1PTK2B | |
| SCHEMBL30714247 | 0.86 | APLNR (0.49) | APLNRTP53HTR2AHTR2CHDAC3 | |
| SCHEMBL12492802 | 0.85 | ALDH1A1 (0.54) | APLNRTP53ALDH1A1MAPK1PTK2B | |
| SCHEMBL12493486 | 0.84 | L3MBTL1 (0.54) | APLNRTP53ALDH1A1MAPK1PTK2B | |
| SCHEMBL12700064 | 0.84 | APLNR (0.49) | APLNRTP53ALDH1A1MAPK1PTK2B | |
| SCHEMBL12493991 | 0.84 | APLNR (0.49) | APLNRTP53ALDH1A1MAPK1PTK2B | |
| SCHEMBL12494428 | 0.84 | APLNR (0.49) | APLNRTP53ALDH1A1MAPK1PTK2B |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 9 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2683703-B1 | NOVEL SUBSTITUTED PHENYL-OXATHIAZINE DERIVATIVES, METHOD FOR PRODUCING THEM, DRUGS CONTAINING SAID COMPOUNDS AND THE USE THEREOF | SANOFI SA (FR) | 2015-05-27 | — | — | EP | disclosed |
| EP-2683702-B1 | NEW SUBSTITUTED PHENYL OXATHIAZINE DERIVATIVES, METHOD FOR THEIR MANUFACTURE, MEDICINES CONTAINING THESE COMPOUNDS AND THEIR APPLICATION | SANOFI SA (FR) | 2014-12-24 | — | — | EP | disclosed |
| EP-2683702-B1 | NEW SUBSTITUTED PHENYL OXATHIAZINE DERIVATIVES, METHOD FOR THEIR MANUFACTURE, MEDICINES CONTAINING THESE COMPOUNDS AND THEIR APPLICATION | SANOFI SA (FR) | 2014-12-24 | — | — | EP | disclosed |
| US-8809324-B2 | Substituted phenyl-oxathiazine derivatives, method for producing them, drugs containing said compounds and the use thereof | SANOFI (FR) | 2014-08-19 | — | — | US | disclosed |
| EP-2683703-A1 | NOVEL SUBSTITUTED PHENYL-OXATHIAZINE DERIVATIVES, METHOD FOR PRODUCING THEM, DRUGS CONTAINING SAID COMPOUNDS AND THE USE THEREOF | SANOFI (FR) | 2014-01-15 | — | — | EP | disclosed |
| EP-2683702-A1 | NOVEL SUBSTITUTED PHENYL-OXATHIAZINE DERIVATIVES, METHOD FOR PRODUCING THEM, DRUGS CONTAINING SAID COMPOUNDS AND THE USE THEREOF | SANOFI (FR) | 2014-01-15 | — | — | EP | disclosed |
| WO-2012120050-A1 | NOVEL SUBSTITUTED PHENYL-OXATHIAZINE DERIVATIVES, METHOD FOR PRODUCING THEM, DRUGS CONTAINING SAID COMPOUNDS AND THE USE THEREOF | SANOFI (FR) | 2012-09-13 | — | — | WO | disclosed |
| WO-2012120050-A1 | NOVEL SUBSTITUTED PHENYL-OXATHIAZINE DERIVATIVES, METHOD FOR PRODUCING THEM, DRUGS CONTAINING SAID COMPOUNDS AND THE USE THEREOF | SANOFI (FR) | 2012-09-13 | — | — | WO | disclosed |
| WO-2012120057-A1 | NOVEL SUBSTITUTED PHENYL-OXATHIAZINE DERIVATIVES, METHOD FOR PRODUCING THEM, DRUGS CONTAINING SAID COMPOUNDS AND THE USE THEREOF | SANOFI (FR) | 2012-09-13 | — | — | WO | disclosed |