Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.43 |
| ▸ | MAPT | P10636 | 6/20 | 0.42 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.42 |
| ▸ | MEN1 | O00255 | 2/20 | 0.42 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.42 |
| ▸ | HPGD | P15428 | 1/20 | 0.42 |
| ▸ | THRB | P10828 | 1/20 | 0.41 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.41 |
| ▸ | XPO1 | O14980 | 1/20 | 0.40 |
| ▸ | TP53 | P04637 | 2/20 | 0.39 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.39 |
| ▸ | LMNA | P02545 | 1/20 | 0.39 |
| ▸ | POLB | P06746 | 1/20 | 0.39 |
| ▸ | PRKCA | P17252 | 1/20 | 0.39 |
| ▸ | PRKCD | Q05655 | 1/20 | 0.39 |
| ▸ | GRIA2 | P42262 | 1/20 | 0.39 |
| ▸ | GRIN1 | Q05586 | 1/20 | 0.39 |
| ▸ | GRIN2A | Q12879 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL12499656 | 0.88 | MAPT (0.43) | KDM4EMAPTKMT2AMEN1ALDH1A1 | |
| SCHEMBL12499717 | 0.87 | KDM4E (0.46) | KDM4EMAPTKMT2AMEN1ALDH1A1 | |
| SCHEMBL12499380 | 0.86 | AADAT (0.41) | MAPTKMT2AMEN1 | |
| SCHEMBL12499589 | 0.81 | ALOX5 (0.43) | KDM4EMAPTKMT2AMEN1ALDH1A1 | |
| SCHEMBL12499698 | 0.79 | MAPT (0.47) | KDM4EMAPTKMT2AALDH1A1HPGD | |
| SCHEMBL12498769 | 0.78 | GPR52 (0.44) | KDM4EMAPTKMT2AMEN1THRB | |
| SCHEMBL12499305 | 0.76 | AADAT (0.43) | ALDH1A1SMN1; SMN2POLB | |
| SCHEMBL12499891 | 0.76 | KMT2A (0.51) | KDM4EMAPTKMT2AMEN1ALDH1A1 | |
| SCHEMBL12498747 | 0.74 | AADAT (0.43) | MAPTKMT2AMEN1ALDH1A1SMN1; SMN2 | |
| SCHEMBL5055900 | 0.73 | KDM4E (0.48) | KDM4EMAPTKMT2AMEN1ALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2012103071-A2 | COMPOUNDS AND COMPOSITIONS | EISAI R&D MANAGEMENT CO., LTD. (JP) | 2012-08-02 | — | — | WO | disclosed |