Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 5/20 | 0.47 |
| ▸ | LMNA | P02545 | 4/20 | 0.47 |
| ▸ | NPC1 | O15118 | 2/20 | 0.47 |
| ▸ | RAB9A | P51151 | 2/20 | 0.47 |
| ▸ | TP53 | P04637 | 1/20 | 0.47 |
| ▸ | NPSR1 | Q6W5P4 | 4/20 | 0.46 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.46 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.46 |
| ▸ | HPGD | P15428 | 2/20 | 0.46 |
| ▸ | TNF | P01375 | 1/20 | 0.46 |
| ▸ | HSP90AA1 | P07900 | 1/20 | 0.46 |
| ▸ | ALOX12 | P18054 | 1/20 | 0.46 |
| ▸ | CCR6 | P51684 | 1/20 | 0.46 |
| ▸ | RUNX1 | Q01196 | 1/20 | 0.46 |
| ▸ | CBFB | Q13951 | 1/20 | 0.46 |
| ▸ | HKDC1 | Q2TB90 | 1/20 | 0.46 |
| ▸ | NOD2 | Q9HC29 | 1/20 | 0.46 |
| ▸ | GPR35 | Q9HC97 | 1/20 | 0.46 |
| ▸ | NOD1 | Q9Y239 | 1/20 | 0.46 |
| ▸ | HTT | P42858 | 1/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL12499589 | 0.88 | ALOX5 (0.43) | MAPTLMNANPC1RAB9ATP53 | |
| SCHEMBL12499656 | 0.87 | MAPT (0.43) | MAPTLMNAALDH1A1KDM4EHSP90AA1 | |
| SCHEMBL12499324 | 0.84 | MAPT (0.40) | MAPTLMNANPC1RAB9AKDM4E | |
| SCHEMBL12498738 | 0.82 | MAPT (0.47) | MAPTLMNANPC1RAB9ATP53 | |
| SCHEMBL12499319 | 0.79 | KDM4E (0.43) | MAPTLMNATP53ALDH1A1KDM4E | |
| SCHEMBL14938276 | 0.78 | KMT2A (0.39) | MAPTLMNANPC1RAB9AALDH1A1 | |
| SCHEMBL15165780 | 0.73 | KMT2A (0.40) | MAPTLMNAALDH1A1KDM4EHPGD | |
| SCHEMBL12499862 | 0.73 | PLA2G2A (0.45) | MAPTLMNANPC1RAB9ATP53 | |
| SCHEMBL12499865 | 0.72 | CCR2 (0.37) | KMT2A | |
| SCHEMBL12499400 | 0.71 | VDR (0.49) | MAPTLMNANPC1RAB9AKDM4E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2012103071-A2 | COMPOUNDS AND COMPOSITIONS | EISAI R&D MANAGEMENT CO., LTD. (JP) | 2012-08-02 | — | — | WO | disclosed |