SCHEMBL12515367

SCHEMBL12515367

COc1ccc(NC(=O)[C@H](CCCNC(=N)N)NC(=O)c2cc(NC(=O)[C@H](CCCNC(=N)N)NC(=O)c3cc(NC(=O)[C@H](CCCNC(=N)N)NC(=O)c4cc(NC(=O)[C@@H](N)CCC(=O)O)ccc4OC)ccc3OC)ccc2OC)cc1C(N)=O

nearest known ligand 0.45

Predicted protein targets (top 8)

geneUniProtsupporting neighboursconfidence
▸ MMP2 P08253 5/20 0.45
▸ S1PR1 P21453 2/20 0.41
▸ S1PR3 Q99500 1/20 0.39
▸ NPY4R P50391 3/20 0.38
▸ NPY1R P25929 1/20 0.38
▸ TSHR P16473 1/20 0.38
▸ SIRT5 Q9NXA8 1/20 0.37
▸ LTA4H P09960 2/20 0.36

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL12515006 1.00 MMP2 (0.45) MMP2S1PR1S1PR3NPY4RNPY1R
SCHEMBL12515005 0.98 MMP2 (0.46) MMP2S1PR1S1PR3NPY4RNPY1R
SCHEMBL19445815 0.98 MMP2 (0.46) MMP2S1PR1S1PR3NPY4RNPY1R
SCHEMBL12515366 0.98 MMP2 (0.46) MMP2S1PR1S1PR3NPY4RNPY1R
SCHEMBL12515000 0.98 MMP2 (0.46) MMP2S1PR1S1PR3NPY4RNPY1R
SCHEMBL12515003 0.98 MMP2 (0.46) MMP2S1PR1S1PR3NPY4RNPY1R
SCHEMBL12514981 0.98 MMP2 (0.46) MMP2S1PR1S1PR3NPY4RNPY1R
SCHEMBL12514973 0.98 MMP2 (0.46) MMP2S1PR1S1PR3NPY4RNPY1R
SCHEMBL17949805 0.96 MMP2 (0.42) MMP2S1PR1S1PR3NPY4RNPY1R
SCHEMBL17949891 0.96 MMP2 (0.42) MMP2S1PR1S1PR3NPY4RNPY1R

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 16 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-10603294-B2 Compounds for use in treatment of mucositis INNOVATION PHARMACEUTICALS INC. (US) 2020-03-31 — — US disclosed
US-20190282521-A1 Compounds For Use In Treatment Of Mucositis POLYMEDIX, INC. 2019-09-19 — — US disclosed
US-10206894-B2 Compounds for use in treatment of mucositis INNOVATION PHARMACEUTICALS INC. (US) 2019-02-19 — — US disclosed
US-20180064664-A1 Compounds For Use In Treatment of Mucositis POLYMEDIX, INC. 2018-03-08 — — US disclosed
US-9795575-B2 Compounds for use in treatment of mucositis INNOVATION PHARMACEUTICALS INC. (US) 2017-10-24 — — US disclosed
EP-2709619-B1 COMPOUNDS FOR USE IN TREATMENT OF MUCOSITIS CELLCEUTIX CORP (US) 2017-10-11 — — EP disclosed
US-20170224640-A1 Compounds For Use In Treatment Of Mucositis INNOVATION PHARMACEUTICALS INC. 2017-08-10 — — US disclosed
US-20170224640-A1 Compounds For Use In Treatment Of Mucositis INNOVATION PHARMACEUTICALS INC. 2017-08-10 — — US disclosed
US-9457027-B2 Compounds for use in treatment of mucostis CELLCEUTIX CORPORATION (US) 2016-10-04 — — US disclosed
US-9155738-B2 Compounds for use in treatment of mucostitis CELLCEUTIX CORPORATION (US) 2015-10-13 — — US disclosed
US-20140364364-A1 COMPOUNDS FOR USE IN TREATMENT OF MUCOSITIS INNOVATION PHARMACEUTICALS INC. 2014-12-11 — — US disclosed
US-8802683-B2 Compounds for use in treatment of mucositis CELLCEUTIX CORPORATION (US) 2014-08-12 — — US disclosed
US-20120295922-A1 Compounds For Use In Treatment Of Mucositis POLYMEDIX, INC. (US) 2012-11-22 — — US disclosed
WO-2012158672-A2 COMPOUNDS FOR USE IN TREATMENT OF MUCOSITIS POLYMEDIX, INC. (US) 2012-11-22 — — WO disclosed
US-20110178104-A1 Anti-Heparin Compounds POLYMEDIX INC. (US) 2011-07-21 — — US disclosed
WO-2011084970-A1 ANTI-HEPARIN COMPOUNDS POLYMEDIX INC. (US) 2011-07-14 — — WO disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (8 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20170224640-A1 Compounds For Use In Treatment Of Mucositis MUC1, FUT6, MMP8 MMP2 367/4885S1PR1 543/4885S1PR3 386/4885
US-10603294-B2 Compounds for use in treatment of mucositis MUC1, FUT6, MMP8 MMP2 367/4885S1PR1 543/4885S1PR3 386/4885
US-20140364364-A1 COMPOUNDS FOR USE IN TREATMENT OF MUCOSITIS MUC1, FUT6, MMP8 MMP2 367/4885S1PR1 543/4885S1PR3 386/4885
US-20120295922-A1 Compounds For Use In Treatment Of Mucositis MUC1, FUT6, MMP8 MMP2 367/4885S1PR1 543/4885S1PR3 386/4885
US-10206894-B2 Compounds for use in treatment of mucositis MUC1, FUT6, SI MMP2 595/4885S1PR1 1574/4885S1PR3 1160/4885
US-20110178104-A1 Anti-Heparin Compounds SERPINC1, CFH, SERPINH1 MMP2 174/4885S1PR1 2383/4885S1PR3 1539/4885
US-20190282521-A1 Compounds For Use In Treatment Of Mucositis MUC1, FUT6, MMP8 MMP2 367/4885S1PR1 543/4885S1PR3 386/4885
US-20180064664-A1 Compounds For Use In Treatment of Mucositis MUC1, FUT6, SI MMP2 595/4885S1PR1 1574/4885S1PR3 1160/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.

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