Ombuine

Ombuine

SCHEMBL1252211

COc1cc(O)c2c(=O)c(O)c(-c3ccc(OC)c(O)c3)oc2c1

nearest known ligand 1.00 ✓ in ChEMBL — recovers established targets

Full drug profile on Sugi Atlas →

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
▸ XDH P47989 2/20 1.00
▸ DPP4 P27487 1/20 1.00
▸ CYP1A1 P04798 3/20 0.84
▸ CYP1A2 P05177 3/20 0.84
▸ CYP1B1 Q16678 3/20 0.84
▸ MAPT P10636 3/20 0.82
▸ MEN1 O00255 3/20 0.82
▸ KMT2A Q03164 3/20 0.82
▸ KDM4E B2RXH2 2/20 0.82
▸ LMNA P02545 2/20 0.82
▸ CYP3A4 P08684 2/20 0.82
▸ IPMK Q8NFU5 2/20 0.82
▸ IP6K2 Q9UHH9 2/20 0.82
▸ APP P05067 1/20 0.82
▸ THRB P10828 1/20 0.82
▸ AKR1B1 P15121 1/20 0.82
▸ RECQL P46063 1/20 0.82
▸ ELAVL3 Q14576 1/20 0.82
▸ HSD17B10 Q99714 1/20 0.82
▸ TDP1 Q9NUW8 1/20 0.82

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
Ombuine SCHEMBL31516400 1.00 XDH (1.00) XDHDPP4CYP1A1CYP1A2CYP1B1
Ombuine SCHEMBL29475881 1.00 XDH (1.00) XDHDPP4CYP1A1CYP1A2CYP1B1
SCHEMBL1250547 0.93 XDH (0.86) XDHDPP4CYP1A1CYP1A2CYP1B1
Tamarixetin SCHEMBL892776 0.91 CYP1A2 (1.00) XDHDPP4CYP1A1CYP1A2CYP1B1
Tamarixetin SCHEMBL29750609 0.91 CYP1A2 (1.00) XDHDPP4CYP1A1CYP1A2CYP1B1
Tamarixetin SCHEMBL30255798 0.91 CYP1A2 (1.00) XDHDPP4CYP1A1CYP1A2CYP1B1
Rhamnazin SCHEMBL39443 0.90 MEN1 (0.84) XDHDPP4CYP1A1CYP1A2CYP1B1
Rhamnazin SCHEMBL29724889 0.90 MEN1 (0.84) XDHDPP4CYP1A1CYP1A2CYP1B1
Rhamnetin SCHEMBL7164573 0.90 MEN1 (1.00) XDHDPP4CYP1A1CYP1A2CYP1B1
Rhamnetin SCHEMBL555118 0.90 MEN1 (1.00) XDHDPP4CYP1A1CYP1A2CYP1B1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 21 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
CN-117777079-A Synthesis method and application of 4', 7-O-dimethyl quercetin 常州大学 2024-03-29 — — CN claimed
US-20110034427-A1 Anti-aging properties of quercetin, 18alpha-glycyrrhetinic acid and hederagenin and their derivatives KORRES S.A. NATURAL PRODUCTS (GR) 2011-02-10 — — US claimed
CN-114031656-B Medicine for treating urinary system lithiasis related diseases and preparation method thereof 张弘 2025-05-27 — — CN disclosed
US-20240115645-A1 DRUG FOR TREATING UROLITHIASIS-RELATED DISEASE, AND PREPARATION METHOD THEREFOR HONG ZHANG (CN) 2024-04-11 — — US disclosed
CN-117777079-A Synthesis method and application of 4', 7-O-dimethyl quercetin 常州大学 2024-03-29 — — CN disclosed
CN-117777079-A Synthesis method and application of 4', 7-O-dimethyl quercetin 常州大学 2024-03-29 — — CN disclosed
CN-117777079-A Synthesis method and application of 4', 7-O-dimethyl quercetin 常州大学 2024-03-29 — — CN disclosed
WO-2024035859-A1 COMBINATION THERAPIES FOR TREATING INFLAMMATION FLAGSHIP PIONEERING INNOVATIONS VI, LLC (US) 2024-02-15 — — WO disclosed
US-11839637-B2 Neuron activator KINJIRUSHI CO., LTD. (JP) 2023-12-12 — — US disclosed
US-11839637-B2 Neuron activator KINJIRUSHI CO., LTD. (JP) 2023-12-12 — — US disclosed
WO-2022151978-A1 DRUG FOR TREATING UROLITHIASIS-RELATED DISEASE, AND PREPARATION METHOD THEREFOR 张弘 2022-07-21 — — WO disclosed
US-20210299199-A1 Neuron activator KINJIRUSHI CO., LTD. (JP) 2021-09-30 — — US disclosed
US-11065288-B2 Neuron activator KINJIRUSHI CO., LTD. (JP) 2021-07-20 — — US disclosed
US-20190099462-A1 Neuron activator KINJIRUSHI CO., LTD. (JP) 2019-04-04 — — US disclosed
US-8367121-B2 Nutraceutical agent for attenuating the neurodegenerative process associated with Parkinson's disease FLORIDA A & M UNIVERSITY (US) 2013-02-05 — — US disclosed
CN-102359014-A Natural anti-microbial fabric containing wrinkled giant hyssop extractive and preparation method thereof WUJIANG LANRUITE TEXTILE PRODUCT CO LTD 2012-02-22 — — CN disclosed
US-20110034427-A1 Anti-aging properties of quercetin, 18alpha-glycyrrhetinic acid and hederagenin and their derivatives KORRES S.A. NATURAL PRODUCTS (GR) 2011-02-10 — — US disclosed
US-20100150895-A1 Nutraceutical agent for attenuating the Neurodegenerative process associated with Parkinson's disease NATIONAL INSTITUTES OF HEALTH (NIH), U.S. DEPT. OF HEALTH AND HUMAN SERVICES (DHHS), U.S. GOVERNMENT 2010-06-17 — — US disclosed
US-20080292607-A1 Nutraceutical agent for attenuating the neurodegenerative process associated with Parkinson's disease MAZZIO ELIZABETH 2008-11-27 — — US disclosed
US-20070116779-A1 Comprehensive nutraceutical agent for treatment/ prevention of Parkinson's disease MAZZIO ELIZABETH 2007-05-24 — — US disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (6 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20110034427-A1 Anti-aging properties of quercetin, 18alpha-glycyrrhetinic acid and hederagenin and their derivatives GLA, AGER, CUTA XDH 1360/4885DPP4 2177/4885CYP1A1 1329/4885
US-20190099462-A1 Neuron activator BDNF, DBH, CHAT XDH 3081/4885DPP4 796/4885CYP1A1 4486/4885
US-11065288-B2 Neuron activator BDNF, DBH, CHAT XDH 3081/4885DPP4 796/4885CYP1A1 4486/4885
US-20240115645-A1 DRUG FOR TREATING UROLITHIASIS-RELATED DISEASE, AND PREPARATION METHOD THEREFOR HK1, HKDC1, HK2 XDH 287/4885DPP4 3351/4885CYP1A1 3173/4885
US-20210299199-A1 Neuron activator BDNF, DBH, CHAT XDH 3081/4885DPP4 796/4885CYP1A1 4486/4885
US-11839637-B2 Neuron activator BDNF, DBH, CHAT XDH 3081/4885DPP4 796/4885CYP1A1 4486/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.

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