Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.59 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.59 |
| ▸ | TRPV1 | Q8NER1 | 2/20 | 0.58 |
| ▸ | HRH3 | Q9Y5N1 | 2/20 | 0.54 |
| ▸ | RBP4 | P02753 | 2/20 | 0.54 |
| ▸ | MALT1 | Q9UDY8 | 1/20 | 0.54 |
| ▸ | MAPT | P10636 | 1/20 | 0.54 |
| ▸ | GAA | P10253 | 1/20 | 0.53 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.53 |
| ▸ | HSD11B1 | P28845 | 1/20 | 0.51 |
| ▸ | CTSB | P07858 | 1/20 | 0.51 |
| ▸ | EPHX2 | P34913 | 1/20 | 0.50 |
| ▸ | PDK2 | Q15119 | 1/20 | 0.49 |
| ▸ | TSHR | P16473 | 1/20 | 0.49 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.49 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4193086 | 0.85 | HRH3 (0.49) | ALDH1A1TRPV1HRH3RBP4MALT1 | |
| SCHEMBL4913516 | 0.85 | DGAT1 (0.49) | ALDH1A1KDM4ETRPV1RBP4MALT1 | |
| SCHEMBL3594750 | 0.84 | MAPT (0.59) | ALDH1A1KDM4EMALT1MAPTGAA | |
| SCHEMBL16648570 | 0.83 | MAPT (0.64) | ALDH1A1KDM4ETRPV1MALT1MAPT | |
| SCHEMBL3435703 | 0.82 | MAPT (0.57) | ALDH1A1KDM4EMALT1MAPTGAA | |
| SCHEMBL19000157 | 0.82 | CTSB (0.64) | ALDH1A1KDM4EMAPTGAACYP2C19 | |
| SCHEMBL1252470 | 0.82 | TRPV1 (0.66) | KDM4ETRPV1HRH3RBP4MALT1 | |
| SCHEMBL3436721 | 0.79 | ALOX15 (0.58) | ALDH1A1MAPTGAACYP2C19CTSB | |
| SCHEMBL4255322 | 0.79 | CTSB (0.68) | ALDH1A1MAPTCYP2C19CTSB | |
| SCHEMBL195417 | 0.78 | KDM4E (0.60) | ALDH1A1KDM4EMAPTGAACYP2C19 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 9 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2862861-B1 | PIPERIDINYLPYRAZOLOPYRIDINE DERIVATIVE | DAIICHI SANKYO CO LTD (JP) | 2016-01-06 | — | — | EP | disclosed |
| US-9150575-B2 | Piperidinylpyrazolopyridine derivative | DAIICHI SANKYO COMPANY, LIMITED (JP) | 2015-10-06 | — | — | US | disclosed |
| US-20150152102-A1 | PIPERIDINYLPYRAZOLOPYRIDINE DERIVATIVE | DAIICHI SANKYO COMPANY, LIMITED (JP) | 2015-06-04 | — | — | US | disclosed |
| EP-2862861-A1 | PIPERIDINYLPYRAZOLOPYRIDINE DERIVATIVE | DAIICHI SANKYO COMPANY, LIMITED (JP) | 2015-04-22 | — | — | EP | disclosed |
| US-8168827-B2 | Amide derivative | AJINOMOTO CO., INC. (JP) | 2012-05-01 | — | — | US | disclosed |
| EP-2281823-A2 | Anti-inflammatory and analgesic piperidine derivatives | Ajinomoto Co., Inc. (JP) | 2011-02-09 | — | — | EP | disclosed |
| US-20090258900-A1 | AMIDE DERIVATIVE | AJINOMOTO CO. INC (JP) | 2009-10-15 | — | — | US | disclosed |
| US-7572815-B2 | Amide derivative | AJINOMOTO CO., INC. (JP) | 2009-08-11 | — | — | US | disclosed |
| EP-1627869-A1 | AMIDE DERIVATIVE | Ajinomoto Co., Inc. (JP) | 2006-02-22 | — | — | EP | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20090258900-A1 | AMIDE DERIVATIVE | NR0B1, NR0B2, NR1I3 | ALDH1A1 2733/4885KDM4E 2426/4885TRPV1 804/4885 |
| US-20150152102-A1 | PIPERIDINYLPYRAZOLOPYRIDINE DERIVATIVE | LCAT, LPL, LCLAT1 | ALDH1A1 907/4885KDM4E 3879/4885TRPV1 591/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.