Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CXCL8 | P10145 | 7/20 | 0.48 |
| ▸ | APLNR | P35414 | 1/20 | 0.48 |
| ▸ | CTSL | P07711 | 3/20 | 0.47 |
| ▸ | CTSS | P25774 | 3/20 | 0.47 |
| ▸ | CTSK | P43235 | 3/20 | 0.47 |
| ▸ | CTSH | P09668 | 1/20 | 0.47 |
| ▸ | MC4R | P32245 | 1/20 | 0.46 |
| ▸ | MC5R | P33032 | 1/20 | 0.46 |
| ▸ | MC3R | P41968 | 1/20 | 0.46 |
| ▸ | MC1R | Q01726 | 1/20 | 0.46 |
| ▸ | CXCR4 | P61073 | 3/20 | 0.46 |
| ▸ | KISS1R | Q969F8 | 2/20 | 0.45 |
| ▸ | C5AR1 | P21730 | 1/20 | 0.45 |
| ▸ | NPY1R | P25929 | 1/20 | 0.45 |
| ▸ | NPY2R | P49146 | 1/20 | 0.45 |
| ▸ | NPY4R | P50391 | 1/20 | 0.45 |
| ▸ | NPY5R | Q15761 | 1/20 | 0.45 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL12589895 | 0.84 | CTSL (0.58) | CXCL8CTSLCTSSCTSKCTSH | |
| SCHEMBL12557082 | 0.84 | CXCR4 (0.52) | CXCL8CXCR4 | |
| SCHEMBL13038613 | 0.83 | CXCR4 (0.50) | CXCL8MC4RMC5RMC3RMC1R | |
| SCHEMBL13881394 | 0.80 | CXCL8 (0.60) | CXCL8CTSLCTSSCTSKCTSH | |
| SCHEMBL13038595 | 0.80 | CXCL8 (0.60) | CXCL8CTSLCTSSCTSKCTSH | |
| SCHEMBL17327767 | 0.76 | CXCR4 (0.61) | CXCL8CTSLCTSSCTSKCTSH | |
| SCHEMBL32679440 | 0.75 | CXCR4 (0.65) | CXCL8CTSLCTSSCTSKCTSH | |
| SCHEMBL30539219 | 0.75 | MC4R (0.61) | CXCL8CTSLCTSSCTSKCTSH | |
| SCHEMBL29835266 | 0.75 | MC4R (0.61) | CXCL8CTSLCTSSCTSKCTSH | |
| SCHEMBL31364213 | 0.75 | CXCR4 (0.58) | CXCL8CTSLCTSSCTSKCTSH |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20130309277-A1 | POLYMER MICELLES CONTAINING ANTHRACYCLINES FOR THE TREATMENT OF CANCER | INTEZYNE TECHNOLOGIES, INCORPORATED (US) | 2013-11-21 | — | — | US | disclosed |
| US-8524784-B2 | Polymer micelles containing anthracylines for the treatment of cancer | INTEZYNE TECHNOLOGIES, INCORPORATED (US) | 2013-09-03 | — | — | US | disclosed |
| US-20110142950-A1 | POLYMER MICELLES CONTAINING ANTHRACYLINES FOR THE TREATMENT OF CANCER | INTEZYNE TECHNOLOGIES, INCORPORATED (US) | 2011-06-16 | — | — | US | disclosed |
| US-20100278932-A1 | POLYMER MICELLES CONTAINING SN-38 FOR THE TREATMENT OF CANCER | INTEZYNE TECHNOLOGIES, INCORPORATED (US) | 2010-11-04 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (3 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20100278932-A1 | POLYMER MICELLES CONTAINING SN-38 FOR THE TREATMENT OF CANCER | MUC1, MSN, SNX9 | CXCL8 58/4885APLNR 329/4885CTSL 4151/4885 |
| US-20130309277-A1 | POLYMER MICELLES CONTAINING ANTHRACYCLINES FOR THE TREATMENT OF CANCER | TOP2B, TOP2A, ABCB4 | CXCL8 3294/4885APLNR 711/4885CTSL 2795/4885 |
| US-20110142950-A1 | POLYMER MICELLES CONTAINING ANTHRACYLINES FOR THE TREATMENT OF CANCER | ABCB4, TOP2A, ANXA5 | CXCL8 3238/4885APLNR 89/4885CTSL 2398/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.