Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | POLH | Q9Y253 | 3/20 | 0.47 |
| ▸ | ALOX5 | P09917 | 5/20 | 0.42 |
| ▸ | ABCB1 | P08183 | 3/20 | 0.36 |
| ▸ | ADORA3 | P0DMS8 | 2/20 | 0.36 |
| ▸ | NOTUM | Q6P988 | 1/20 | 0.35 |
| ▸ | CYP3A4 | P08684 | 4/20 | 0.35 |
| ▸ | TDP1 | Q9NUW8 | 4/20 | 0.35 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.35 |
| ▸ | CYP2C9 | P11712 | 2/20 | 0.35 |
| ▸ | TSHR | P16473 | 2/20 | 0.35 |
| ▸ | CYP2C19 | P33261 | 2/20 | 0.35 |
| ▸ | KMT2A | Q03164 | 5/20 | 0.33 |
| ▸ | AMY1A | P0DUB6 | 2/20 | 0.33 |
| ▸ | PIM1 | P11309 | 2/20 | 0.33 |
| ▸ | CD38 | P28907 | 2/20 | 0.33 |
| ▸ | KDM4E | B2RXH2 | 5/20 | 0.32 |
| ▸ | MEN1 | O00255 | 4/20 | 0.32 |
| ▸ | LMNA | P02545 | 3/20 | 0.32 |
| ▸ | MAPT | P10636 | 3/20 | 0.32 |
| ▸ | RECQL | P46063 | 3/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL12557413 | 0.88 | POLH (0.50) | POLHALOX5ABCB1ADORA3CYP3A4 | |
| SCHEMBL25734128 | 0.80 | POLH (0.49) | POLHALOX5ADORA3NOTUMCYP3A4 | |
| SCHEMBL12557410 | 0.79 | ALOX5 (0.44) | POLHALOX5ADORA3NOTUMCYP3A4 | |
| SCHEMBL12557425 | 0.79 | ALOX5 (0.60) | ALOX5ABCB1ADORA3CYP3A4TDP1 | |
| SCHEMBL12557415 | 0.77 | POLH (0.62) | POLHALOX5ABCB1ADORA3CYP3A4 | |
| SCHEMBL13056253 | 0.77 | POLH (0.78) | POLHALOX5ABCB1ADORA3CYP3A4 | |
| SCHEMBL29187566 | 0.75 | ALOX5 (0.43) | POLHALOX5ABCB1ADORA3NOTUM | |
| SCHEMBL12557424 | 0.70 | ALOX5 (0.51) | POLHALOX5ABCB1CYP3A4TDP1 | |
| SCHEMBL13056258 | 0.69 | ALDH1A1 (0.71) | POLHABCB1CYP3A4TDP1ALDH1A1 | |
| SCHEMBL13776268 | 0.69 | POLH (0.82) | POLHALOX5ABCB1ADORA3CYP3A4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20110144194-A1 | CHROMENONE DERIVATIVES USEFUL FOR THE TREATMENT OF NEURODEGENERATIVE DISEASES | AXOGLIA THERAPEUTICS (LU) | 2011-06-16 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20110144194-A1 | CHROMENONE DERIVATIVES USEFUL FOR THE TREATMENT OF NEURODEGENERATIVE DISEASES | PARK7, CDR2, SNCA | POLH 4378/4885ALOX5 2924/4885ABCB1 2178/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.