Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HPGD | P15428 | 2/20 | 0.40 |
| ▸ | OPRM1 | P35372 | 2/20 | 0.39 |
| ▸ | CTSL | P07711 | 2/20 | 0.39 |
| ▸ | CTSB | P07858 | 2/20 | 0.39 |
| ▸ | CTSK | P43235 | 2/20 | 0.39 |
| ▸ | GAA | P10253 | 1/20 | 0.39 |
| ▸ | NPC1 | O15118 | 1/20 | 0.38 |
| ▸ | RAB9A | P51151 | 1/20 | 0.38 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.38 |
| ▸ | ADRB1 | P08588 | 1/20 | 0.38 |
| ▸ | PAX3 | P23760 | 1/20 | 0.38 |
| ▸ | FOXO1 | Q12778 | 1/20 | 0.38 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.37 |
| ▸ | PKM | P14618 | 1/20 | 0.37 |
| ▸ | MAPT | P10636 | 1/20 | 0.36 |
| ▸ | CKS1B | P61024 | 1/20 | 0.36 |
| ▸ | SKP1 | P63208 | 1/20 | 0.36 |
| ▸ | SKP2 | Q13309 | 1/20 | 0.36 |
| ▸ | P2RX7 | Q99572 | 1/20 | 0.36 |
| ▸ | OPRD1 | P41143 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5495261 | 0.67 | CTSL (0.54) | HPGDOPRM1CTSLCTSBCTSK | |
| SCHEMBL18942207 | 0.66 | HPGD (0.51) | HPGDOPRM1CTSLCTSBCTSK | |
| SCHEMBL18941761 | 0.66 | HPGD (0.51) | HPGDOPRM1CTSLCTSBCTSK | |
| SCHEMBL10353965 | 0.65 | OPRM1 (0.58) | HPGDOPRM1CTSLCTSBCTSK | |
| SCHEMBL4956356 | 0.65 | CTSL (0.59) | HPGDOPRM1CTSLCTSBCTSK | |
| SCHEMBL2303341 | 0.64 | HDAC3 (0.64) | HPGDCTSLCTSBCTSKGAA | |
| SCHEMBL5291134 | 0.64 | GBA1 (0.51) | HPGDOPRM1CTSLCTSBCTSK | |
| SCHEMBL2937707 | 0.64 | GBA1 (0.51) | HPGDOPRM1CTSLCTSBCTSK | |
| SCHEMBL14498500 | 0.64 | SLC6A2 (0.49) | HPGDOPRM1CTSLCTSBCTSK | |
| SCHEMBL31414557 | 0.62 | HPGD (0.47) | HPGDOPRM1CTSLCTSBCTSK |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 24 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-9084423-B2 | Inhibition of bacterial biofilms with imidazole derivatives | NORTH CAROLINA STATE UNIVERSITY (US) | 2015-07-21 | — | — | US | disclosed |
| US-9084423-B2 | Inhibition of bacterial biofilms with imidazole derivatives | NORTH CAROLINA STATE UNIVERSITY (US) | 2015-07-21 | — | — | US | disclosed |
| US-8927029-B2 | Inhibition of biofilms in plants with imidazole derivatives | NORTH CAROLINA STATE UNIVERSITY (US) | 2015-01-06 | — | — | US | disclosed |
| US-8927029-B2 | Inhibition of biofilms in plants with imidazole derivatives | NORTH CAROLINA STATE UNIVERSITY (US) | 2015-01-06 | — | — | US | disclosed |
| US-20140127273-A1 | INHIBITION OF BACTERIAL BIOFILMS WITH IMIDAZOLE DERIVATIVES | NORTH CAROLINA STATE UNIVERSITY (US) | 2014-05-08 | — | — | US | disclosed |
| US-20140127273-A1 | INHIBITION OF BACTERIAL BIOFILMS WITH IMIDAZOLE DERIVATIVES | NORTH CAROLINA STATE UNIVERSITY (US) | 2014-05-08 | — | — | US | disclosed |
| US-20140079808-A1 | INHIBITION OF BIOFILMS IN PLANTS WITH IMIDAZOLE DERIVATIVES | NORTH CAROLINA STATE UNIVERSITY (US) | 2014-03-20 | — | — | US | disclosed |
| US-20140079808-A1 | INHIBITION OF BIOFILMS IN PLANTS WITH IMIDAZOLE DERIVATIVES | NORTH CAROLINA STATE UNIVERSITY (US) | 2014-03-20 | — | — | US | disclosed |
| US-8653124-B2 | Inhibition of bacterial biofilms with imidazole derivatives | NORTH CAROLINA STATE UNIVERSITY (US) | 2014-02-18 | — | — | US | disclosed |
| US-8653124-B2 | Inhibition of bacterial biofilms with imidazole derivatives | NORTH CAROLINA STATE UNIVERSITY (US) | 2014-02-18 | — | — | US | disclosed |
| US-20110150819-A1 | INHIBITION OF BACTERIAL BIOFILMS WITH IMIDAZOLE DERIVATIVES | MELANDER CHRISTIAN | 2011-06-23 | — | — | US | disclosed |
| US-20110150819-A1 | INHIBITION OF BACTERIAL BIOFILMS WITH IMIDAZOLE DERIVATIVES | MELANDER CHRISTIAN | 2011-06-23 | — | — | US | disclosed |
| US-7906544-B2 | Dentifrices; stents; catheters; grafts | NORTH CAROLINA STATE UNIVERSITY (US) | 2011-03-15 | — | — | US | disclosed |
| US-7906544-B2 | Dentifrices; stents; catheters; grafts | NORTH CAROLINA STATE UNIVERSITY (US) | 2011-03-15 | — | — | US | disclosed |
| US-20090143230-A1 | INHIBITION OF BIOFILMS IN PLANTS WITH IMIDAZOLE DERIVATIVES | NORTH CAROLINA STATE UNIVERSITY (US) | 2009-06-04 | — | — | US | disclosed |
| US-20090143230-A1 | INHIBITION OF BIOFILMS IN PLANTS WITH IMIDAZOLE DERIVATIVES | NORTH CAROLINA STATE UNIVERSITY (US) | 2009-06-04 | — | — | US | disclosed |
| WO-2009070304-A1 | INHIBITION OF BIOFILMS IN PLANTS WITH IMIDAZOLE DERIVATIVES | NORTH CAROLINA STATE UNIVERSITY (US) | 2009-06-04 | — | — | WO | disclosed |
| WO-2008094479-A1 | INHIBITION OF BACTERIAL BIOFILMS WITH IMIDAZOLE DERIVATIVES | NORTH CAROLINA STATE UNIVERSITY (US) | 2008-08-07 | — | — | WO | disclosed |
| US-20080181923-A1 | INHIBITION OF BACTERIAL BIOFILMS WITH IMIDAZOLE DERIVATIVES | NORTH CAROLINA STATE UNIVERSITY | 2008-07-31 | — | — | US | disclosed |
| US-20080181923-A1 | INHIBITION OF BACTERIAL BIOFILMS WITH IMIDAZOLE DERIVATIVES | NORTH CAROLINA STATE UNIVERSITY | 2008-07-31 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (5 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20080181923-A1 | INHIBITION OF BACTERIAL BIOFILMS WITH IMIDAZOLE DERIVATIVES | O60361, TFPI, BLVRB | HPGD 780/4885OPRM1 3929/4885CTSL 2385/4885 |
| US-20140079808-A1 | INHIBITION OF BIOFILMS IN PLANTS WITH IMIDAZOLE DERIVATIVES | ITPA, SOD1, ICMT | HPGD 3164/4885OPRM1 3192/4885CTSL 2339/4885 |
| US-20110150819-A1 | INHIBITION OF BACTERIAL BIOFILMS WITH IMIDAZOLE DERIVATIVES | O60361, TFPI, BLVRB | HPGD 780/4885OPRM1 3929/4885CTSL 2385/4885 |
| US-20140127273-A1 | INHIBITION OF BACTERIAL BIOFILMS WITH IMIDAZOLE DERIVATIVES | O60361, TFPI, BLVRB | HPGD 780/4885OPRM1 3929/4885CTSL 2385/4885 |
| US-20090143230-A1 | INHIBITION OF BIOFILMS IN PLANTS WITH IMIDAZOLE DERIVATIVES | ITPA, SOD1, ICMT | HPGD 3164/4885OPRM1 3192/4885CTSL 2339/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.