Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MKNK1 | Q9BUB5 | 1/20 | 0.68 |
| ▸ | MKNK2 | Q9HBH9 | 1/20 | 0.68 |
| ▸ | NNMT | P40261 | 2/20 | 0.53 |
| ▸ | HSD17B1 | P14061 | 1/20 | 0.50 |
| ▸ | HSD17B2 | P37059 | 1/20 | 0.50 |
| ▸ | OXTR | P30559 | 1/20 | 0.49 |
| ▸ | CYP2A6 | P11509 | 2/20 | 0.46 |
| ▸ | HDAC6 | Q9UBN7 | 2/20 | 0.46 |
| ▸ | HDAC3 | O15379 | 1/20 | 0.46 |
| ▸ | CD274 | Q9NZQ7 | 1/20 | 0.46 |
| ▸ | ERN1 | O75460 | 2/20 | 0.44 |
| ▸ | KCNH2 | Q12809 | 2/20 | 0.44 |
| ▸ | GPR119 | Q8TDV5 | 1/20 | 0.43 |
| ▸ | GABRA1 | P14867 | 1/20 | 0.43 |
| ▸ | KLK3 | P07288 | 1/20 | 0.43 |
| ▸ | PDGFRB | P09619 | 1/20 | 0.42 |
| ▸ | PDGFRA | P16234 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL20906965 | 0.87 | NNMT (0.64) | MKNK1MKNK2NNMTOXTRKCNH2 | |
| SCHEMBL12641872 | 0.82 | MKNK1 (0.73) | MKNK1MKNK2NNMTHSD17B1HSD17B2 | |
| SCHEMBL30280631 | 0.82 | MKNK1 (0.73) | MKNK1MKNK2NNMTHSD17B1HSD17B2 | |
| SCHEMBL29365356 | 0.82 | MKNK1 (0.73) | MKNK1MKNK2NNMTHSD17B1HSD17B2 | |
| SCHEMBL1870306 | 0.82 | MKNK1 (0.73) | MKNK1MKNK2NNMTHSD17B1HSD17B2 | |
| SCHEMBL2945799 | 0.81 | MKNK1 (0.71) | MKNK1MKNK2NNMTHSD17B1HSD17B2 | |
| SCHEMBL27417480 | 0.79 | NAPRT (0.50) | MKNK1MKNK2CYP2A6 | |
| SCHEMBL12875869 | 0.78 | MKNK1 (0.68) | MKNK1MKNK2NNMTHSD17B1HSD17B2 | |
| SCHEMBL31174412 | 0.77 | CYP2A6 (0.68) | MKNK1MKNK2NNMTHSD17B1HSD17B2 | |
| SCHEMBL12418688 | 0.77 | KDM4E (0.56) | HSD17B1CD274 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20110150769-A1 | IDENTIFICATION AND USE OF COMPOUNDS FOR TREATING PERSISTENT PAIN | THE JOHN HOPKINS UNIVERSITY | 2011-06-23 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20110150769-A1 | IDENTIFICATION AND USE OF COMPOUNDS FOR TREATING PERSISTENT PAIN | MRGPRX1, MRGPRX2, OPRL1 | MKNK1 1952/4885MKNK2 1519/4885NNMT 2586/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.