Known targets — ChEMBL curated mechanism
ACHEBDKRB2CHRM1CHRM2CHRM3CHRNA1CHRNB1CHRNDCHRNECHRNGGUCY1A1GUCY1A2GUCY1B1GUCY1B2NAMPTPTAFRSLC10A2SLC6A2SLC6A3TACR1dacAdacBdacCftsImrcAmrcBmrdA
The experimentally established mechanism targets of Hydrochloric Acid. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CHRM1 known ✓ | P11229 | 4/20 | 0.38 |
| ▸ | CHRM3 known ✓ | P20309 | 4/20 | 0.38 |
| ▸ | CHRM2 known ✓ | P08172 | 3/20 | 0.37 |
| ▸ | ACHE known ✓ | P22303 | 2/20 | 0.37 |
| ▸ | LMNA | P02545 | 2/20 | 0.40 |
| ▸ | APEX1 | P27695 | 2/20 | 0.40 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.40 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.39 |
| ▸ | CHRM5 | P08912 | 4/20 | 0.38 |
| ▸ | BLM | P54132 | 2/20 | 0.38 |
| ▸ | POLB | P06746 | 1/20 | 0.38 |
| ▸ | ATM | Q13315 | 1/20 | 0.38 |
| ▸ | MAPT | P10636 | 1/20 | 0.38 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.38 |
| ▸ | SLC5A7 | Q9GZV3 | 1/20 | 0.38 |
| ▸ | CYP2D6 | P10635 | 2/20 | 0.37 |
| ▸ | CYP2C19 | P33261 | 2/20 | 0.37 |
| ▸ | CHRM4 | P08173 | 3/20 | 0.37 |
| ▸ | TSHR | P16473 | 1/20 | 0.36 |
| ▸ | CHRNB2 | P17787 | 2/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL14438177 | 0.78 | ACHE (0.36) | LMNAAPEX1ALDH1A1SMN1; SMN2CHRM5 | |
| SCHEMBL1831846 | 0.77 | KDM4E (0.52) | ALDH1A1SMN1; SMN2CHRM5CHRM1CHRM3 | |
| Hydrochloric Acid SCHEMBL10775883 | 0.76 | MEN1 (0.56) | LMNAAPEX1SMN1; SMN2CHRM5CHRM1 | |
| SCHEMBL31613206 | 0.74 | CYP2D6 (0.43) | LMNAALDH1A1SMN1; SMN2POLBCYP2D6 | |
| SCHEMBL13612347 | 0.73 | MEN1 (0.58) | ALDH1A1ACHE | |
| Hydrochloric Acid SCHEMBL137143 | 0.73 | ZDHHC20 (0.50) | LMNAAPEX1ALDH1A1SMN1; SMN2CHRM5 | |
| Hydrochloric Acid SCHEMBL422218 | 0.73 | CHRM5 (0.38) | LMNAAPEX1ALDH1A1SMN1; SMN2CHRM5 | |
| Hydrochloric Acid SCHEMBL8777430 | 0.72 | ACHE (0.49) | LMNAAPEX1ALDH1A1SMN1; SMN2CHRM5 | |
| SCHEMBL16316411 | 0.71 | KMT2A (0.42) | ALDH1A1CHRM5CHRM1CHRM3MAPT | |
| SCHEMBL16316314 | 0.71 | POLB (0.42) | LMNAAPEX1ALDH1A1SMN1; SMN2CHRM5 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2467155-A1 | MULTIEPITOPE VACCINE FOR HER2/NEU-ASSOCIATED CANCERS | Pevion Biotech AG (CH) | 2012-06-27 | — | — | EP | disclosed |
| WO-2011020604-A1 | MULTIEPITOPE VACCINE FOR HER2/NEU-ASSOCIATED CANCERS | PEVION BIOTECH AG (CH) | 2011-02-24 | — | — | WO | disclosed |