SCHEMBL12623940

SCHEMBL12623940

O=S(=O)(c1ccc(OC(F)(F)F)cc1)N1CCOC12CCNCC2

nearest known ligand 0.55

Predicted protein targets (top 15)

geneUniProtsupporting neighboursconfidence
L3MBTL1 Q9Y468 2/20 0.50
ALDH1A1 P00352 1/20 0.50
MMP3 P08254 2/20 0.45
MMP1 P03956 1/20 0.45
MMP9 P14780 1/20 0.45
MMP8 P22894 1/20 0.45
MMP13 P45452 1/20 0.45
MMP14 P50281 1/20 0.45
MEN1 O00255 3/20 0.43
KMT2A Q03164 3/20 0.43
HCRTR1 O43613 2/20 0.41
HCRTR2 O43614 2/20 0.41
MMP10 P09238 1/20 0.41
KCNH2 Q12809 1/20 0.41
LIPE Q05469 1/20 0.40

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL12655999 0.87 L3MBTL1 (0.58) L3MBTL1ALDH1A1MEN1KMT2AHCRTR1
SCHEMBL12623952 0.84 L3MBTL1 (0.63) L3MBTL1ALDH1A1HCRTR1HCRTR2
SCHEMBL15426435 0.84 L3MBTL1 (0.53) L3MBTL1ALDH1A1MMP3MMP9MMP8
SCHEMBL12627182 0.83 L3MBTL1 (0.56) L3MBTL1ALDH1A1HCRTR1HCRTR2
SCHEMBL12621946 0.82 L3MBTL1 (0.61) L3MBTL1ALDH1A1MEN1KMT2A
SCHEMBL15423912 0.81 L3MBTL1 (0.45) L3MBTL1ALDH1A1MEN1KMT2AHCRTR1
SCHEMBL15427209 0.81 L3MBTL1 (0.52) L3MBTL1ALDH1A1MEN1KMT2A
SCHEMBL12623976 0.81 ALDH1A1 (0.49) L3MBTL1ALDH1A1HCRTR1HCRTR2
SCHEMBL12673214 0.80 L3MBTL1 (0.56) L3MBTL1ALDH1A1HCRTR1HCRTR2
SCHEMBL12623988 0.80 L3MBTL1 (0.56) L3MBTL1ALDH1A1HCRTR1HCRTR2

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 49 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-11661580-B2 Method of inhibiting tau phosphorylation CASSAVA SCIENCES, INC. (US) 2023-05-30 US disclosed
US-11661580-B2 Method of inhibiting tau phosphorylation CASSAVA SCIENCES, INC. (US) 2023-05-30 US disclosed
US-11385221-B2 Alzheimer's disease assay in a living patient PAIN THERAPEUTICS, INC. (US) 2022-07-12 US disclosed
WO-2022098700-A1 INHIBITING AN IMMUNE RESPONSE MEDIATED BY ONE OR MORE OF TLR2, RAGE, CCR5, CXCR4 AND CD4 CASSAVA SCIENCES, INC. (US) 2022-05-12 WO disclosed
US-20210389298-A1 Alzheimer's Disease Assay in a Living Patient PAIN THERAPEUTICS, INC. (US) 2021-12-16 US disclosed
US-20210095248-A1 METHOD OF INHIBITING TAU PHOSPHORYLATION PAIN THERAPEUTICS, INC. 2021-04-01 US disclosed
EP-3791875-A1 METHOD FOR INHIBITING GROWTH OF CANCER CELLS Pain Therapeutics, Inc. (US) 2021-03-17 EP disclosed
US-10760052-B2 Method of inhibiting tau phosphorylation Cassava Science, Inc. (US) 2020-09-01 US disclosed
EP-3054956-B1 METHOD FOR INHIBITING GROWTH OF CANCER CELLS PAIN THERAPEUTICS INC (US) 2020-08-26 EP disclosed
US-20190271686-A1 ALZHEIMER'S DISEASE ASSAY IN A LIVING PATIENT PAIN THERAPEUTICS, INC. 2019-09-05 US disclosed
US-20140017698-A1 ALZHEIMER'S DISEASE ASSAY IN A LIVING PATIENT WANG HOAU-YAN (US) 2014-01-16 US disclosed
US-20140017698-A1 ALZHEIMER'S DISEASE ASSAY IN A LIVING PATIENT WANG HOAU-YAN (US) 2014-01-16 US disclosed
WO-2014012054-A1 ALZHEIMER'S DISEASE ASSAY IN A LIVING PATENT PAIN THERAPEUTICS, INC. (US) 2014-01-16 WO disclosed
US-20140017699-A1 ALZHEIMER'S DISEASE ASSAY IN A LIVING PATIENT CASSAVA SCIENCES, INC. 2014-01-16 US disclosed
US-20140017699-A1 ALZHEIMER'S DISEASE ASSAY IN A LIVING PATIENT CASSAVA SCIENCES, INC. 2014-01-16 US disclosed
US-20110105487-A1 FILAMIN A BINDING ANTI-INFLAMMATORY AND ANALGESIC PAIN THERAPEUTICS 2011-05-05 US disclosed
US-20110105487-A1 FILAMIN A BINDING ANTI-INFLAMMATORY AND ANALGESIC PAIN THERAPEUTICS 2011-05-05 US disclosed
US-20110105481-A1 FILAMIN A BINDING ANTI-INFLAMMATORY AND ANALGESIC PAIN THERAPEUTICS 2011-05-05 US disclosed
US-20110105481-A1 FILAMIN A BINDING ANTI-INFLAMMATORY AND ANALGESIC PAIN THERAPEUTICS 2011-05-05 US disclosed
WO-2010051497-A1 FILAMIN A BINDING ANTI-INFLAMMATORY AND ANALGESIC PAIN THERAPEUTICS, INC. (US) 2010-05-06 WO disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (5 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20110105487-A1 FILAMIN A BINDING ANTI-INFLAMMATORY AND ANALGESIC FLNA, FLNB, FPR1 L3MBTL1 4055/4885ALDH1A1 3041/4885MMP3 2063/4885
US-10760052-B2 Method of inhibiting tau phosphorylation FLNA, FLNB, MAPT L3MBTL1 1789/4885ALDH1A1 4388/4885MMP3 4460/4885
US-20110105481-A1 FILAMIN A BINDING ANTI-INFLAMMATORY AND ANALGESIC FLNA, FLNB, OPRK1 L3MBTL1 3291/4885ALDH1A1 2575/4885MMP3 2181/4885
US-20210095248-A1 METHOD OF INHIBITING TAU PHOSPHORYLATION FLNA, FLNB, MAPT L3MBTL1 1789/4885ALDH1A1 4388/4885MMP3 4460/4885
US-11661580-B2 Method of inhibiting tau phosphorylation FLNA, FLNB, MAPT L3MBTL1 1789/4885ALDH1A1 4388/4885MMP3 4460/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.