Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | FOLH1 | Q04609 | 2/20 | 0.42 |
| ▸ | SIRT6 | Q8N6T7 | 1/20 | 0.40 |
| ▸ | SIRT1 | Q96EB6 | 1/20 | 0.40 |
| ▸ | SIRT5 | Q9NXA8 | 3/20 | 0.40 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.39 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.39 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.39 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.39 |
| ▸ | ALB | P02768 | 3/20 | 0.37 |
| ▸ | MEN1 | O00255 | 1/20 | 0.35 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.35 |
| ▸ | HPGD | P15428 | 1/20 | 0.35 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.35 |
| ▸ | TGM2 | P21980 | 2/20 | 0.35 |
| ▸ | CA1 | P00915 | 2/20 | 0.34 |
| ▸ | CA2 | P00918 | 2/20 | 0.34 |
| ▸ | PAOX | Q6QHF9 | 3/20 | 0.34 |
| ▸ | NAMPT | P43490 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL13901992 | 0.93 | SIRT6 (0.46) | FOLH1SIRT6SIRT1SIRT5SMN1; SMN2 | |
| SCHEMBL12694367 | 0.93 | FOLH1 (0.39) | FOLH1SIRT6SIRT1SIRT5SMN1; SMN2 | |
| SCHEMBL12509746 | 0.91 | SIRT1 (0.38) | FOLH1SIRT6SIRT1SIRT5SMN1; SMN2 | |
| SCHEMBL18206801 | 0.87 | CA1 (0.49) | MEN1ALDH1A1KMT2ACA1CA2 | |
| SCHEMBL18206800 | 0.87 | CA1 (0.49) | MEN1ALDH1A1KMT2ACA1CA2 | |
| SCHEMBL29973774 | 0.85 | TAS1R3 (0.39) | SIRT6SIRT1SMN1; SMN2MEN1ALDH1A1 | |
| SCHEMBL10017795 | 0.85 | EPHX1 (0.38) | FOLH1SIRT1MEN1KMT2ATGM2 | |
| SCHEMBL327848 | 0.85 | EPHX1 (0.38) | FOLH1SIRT1MEN1KMT2ATGM2 | |
| SCHEMBL22449562 | 0.84 | TGM2 (0.36) | SIRT6SIRT1SIRT5SMN1; SMN2MEN1 | |
| SCHEMBL12213104 | 0.84 | MEN1 (0.41) | SIRT6SIRT1SIRT5SMN1; SMN2ALB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 20 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-108699095-B | Trigger activatable metabolic sugar precursors for cancer selective markers and targeting | 伊利诺伊大学评议会 | 2022-05-13 | — | — | CN | disclosed |
| WO-2017062800-A1 | TRIGGER-ACTIVATABLE METABOLIC SUGAR PRECURSORS FOR CANCER-SELECTIVE LABELING AND TARGETING | THE BOARD OF TRUSTEES OF THE UNIVERSITY OF ILLINOIS (US) | 2017-04-13 | — | — | WO | disclosed |
| US-8865149-B2 | Polymeric reagents comprising a ketone or a related functional group | NEKTAR THERAPEUTICS (US) | 2014-10-21 | — | — | US | disclosed |
| US-8703893-B2 | Four branched dendrimer-PEG for conjugation to proteins and peptides | CENTRO DE INGENIENIA GENETICA Y BIOTECNOLOGIA (CU) | 2014-04-22 | — | — | US | disclosed |
| US-8354477-B2 | Multi-armed, monofunctional, and hydrolytically stable derivatives of poly(ethylene glycol) and related polymers for modification of surfaces and molecules | NEKTAR THERAPEUTICS (US) | 2013-01-15 | — | — | US | disclosed |
| US-8318923-B2 | Nucleic acid modulators of glycoprotein VI | REGADO BIOSCIENCES, INC. (US) | 2012-11-27 | — | — | US | disclosed |
| US-20120277419-A1 | METHOD FOR MANUFACTURING PEGYLATED OLIGONUCLEOTIDES | REGADO BIOSCIENCES, INC. | 2012-11-01 | — | — | US | disclosed |
| US-8216793-B2 | Detection of antibody that binds to water soluble polymer-modified polypeptides | BAXTER INTERNATIONAL INC. (US) | 2012-07-10 | — | — | US | disclosed |
| US-7939654-B2 | Platelet derived growth factor (PDGF) nucleic acid ligand complexes | GILEAD SCIENCES, INC. (US) | 2011-05-10 | — | — | US | disclosed |
| US-20110070592-A1 | DETECTION OF ANTIBODY THAT BINDS TO WATER SOLUBLE POLYMER-MODIFIED POLYPEPTIDES | BAXTER INTERNATIONAL INC. (US) | 2011-03-24 | — | — | US | disclosed |
| US-20100311820-A1 | NUCLEIC ACID MODULATORS OF GLYCOPROTEIN VI | REGADO BIOSCIENCES, INC (US) | 2010-12-09 | — | — | US | disclosed |
| US-20100298496-A1 | MULTI-ARMED, MONOFUNCTIONAL, AND HYDROLYTICALLY STABLE DERIVATIVES OF POLY(ETHYLENE GLYCOL) AND RELATED POLYMERS FOR MODIFICATION OF SURFACES AND MOLECULES | NEKTAR THERAPEUTICS (US) | 2010-11-25 | — | — | US | disclosed |
| US-7786221-B2 | Multi-armed, monofunctional, and hydrolytically stable derivatives of poly (ethylene glycol) and related polymers for modification of surfaces and molecules | NEKTAR THERAPEUTICS (US) | 2010-08-31 | — | — | US | disclosed |
| US-20100029922-A1 | Platelet Derived Growth Factor (PDGF) Nucleic Acid Ligand Complexes | GILEAD SCIENCES, INC. (US) | 2010-02-04 | — | — | US | disclosed |
| US-20100009908-A1 | Galectin 9-Polymer Conjugates | GALPHARMA CO., LTD. (JP) | 2010-01-14 | — | — | US | disclosed |
| US-20090258012-A1 | COMPOSITIONS AND METHODS FOR TREATING INFLAMMATORY DISORDERS | DOMANTIS LIMITED (GB) | 2009-10-15 | — | — | US | disclosed |
| US-7531524-B2 | Modulators of coagulation factors with enhanced stability | REGADO BIOSCIENCES, INC. (US) | 2009-05-12 | — | — | US | disclosed |
| US-20090082537-A1 | FOUR BRANCHED DENDRIMER-PEG FOR CONJUGATION TO PROTEINS AND PEPTIDES | CENTRO DE INGENIENIA GENETICA Y BIOTECNOLOGIA (CU) | 2009-03-26 | — | — | US | disclosed |
| US-20090054590-A1 | Multi-armed, monofunctional, and hydrolytically stable derivatives of poly (ethylene glycol) and related polymers for modification of surfaces and molecules | NEKTAR THERAPEUTICS AL, CORPORATION (US) | 2009-02-26 | — | — | US | disclosed |
| US-20080125383-A1 | For host undergoing surgery or coronary artery bypass | TOBIRA THERAPEUTICS, INC. | 2008-05-29 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (7 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20090258012-A1 | COMPOSITIONS AND METHODS FOR TREATING INFLAMMATORY DISORDERS | TNF, IL5, C5 | FOLH1 1092/4885SIRT6 3874/4885SIRT1 4294/4885 |
| US-20100311820-A1 | NUCLEIC ACID MODULATORS OF GLYCOPROTEIN VI | GP6, DNASE1L3, SELPLG | FOLH1 1164/4885SIRT6 3028/4885SIRT1 4409/4885 |
| US-20120277419-A1 | METHOD FOR MANUFACTURING PEGYLATED OLIGONUCLEOTIDES | DCLRE1B, RNGTT, CPSF7 | FOLH1 543/4885SIRT6 3893/4885SIRT1 4492/4885 |
| US-20080125383-A1 | For host undergoing surgery or coronary artery bypass | NSUN2, SERPINC1, NSUN3 | FOLH1 828/4885SIRT6 1741/4885SIRT1 2152/4885 |
| US-20100298496-A1 | MULTI-ARMED, MONOFUNCTIONAL, AND HYDROLYTICALLY STABLE DERIVATIVES OF POLY(ETHYLENE GLYCOL) AND RELATED POLYMERS FOR MODIFICATION OF SURFACES AND MOLECULES | MPG, PARG, PCNA | FOLH1 2661/4885SIRT6 3381/4885SIRT1 4210/4885 |
| US-20090082537-A1 | FOUR BRANCHED DENDRIMER-PEG FOR CONJUGATION TO PROTEINS AND PEPTIDES | HDGF, CLTB, EGFR | FOLH1 786/4885SIRT6 3105/4885SIRT1 4127/4885 |
| US-20100009908-A1 | Galectin 9-Polymer Conjugates | LGALS9, LGALS1, LGALS2 | FOLH1 578/4885SIRT6 1337/4885SIRT1 1518/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.