Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KLK1 | P06870 | 1/20 | 0.61 |
| ▸ | KLK5 | Q9Y337 | 1/20 | 0.61 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.61 |
| ▸ | PKM | P14618 | 1/20 | 0.56 |
| ▸ | RAB9A | P51151 | 5/20 | 0.55 |
| ▸ | NPC1 | O15118 | 4/20 | 0.55 |
| ▸ | MAPT | P10636 | 2/20 | 0.55 |
| ▸ | LMNA | P02545 | 2/20 | 0.55 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.55 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.55 |
| ▸ | ABCB1 | P08183 | 1/20 | 0.47 |
| ▸ | DDAH1 | O94760 | 1/20 | 0.46 |
| ▸ | POLB | P06746 | 1/20 | 0.46 |
| ▸ | TSHR | P16473 | 2/20 | 0.46 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.46 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.45 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.45 |
| ▸ | SMN1; SMN2 | Q16637 | 4/20 | 0.44 |
| ▸ | TP53 | P04637 | 2/20 | 0.44 |
| ▸ | GAA | P10253 | 2/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL10371770 | 0.84 | KLK1 (0.68) | KLK1KLK5HSD17B10PKMRAB9A | |
| SCHEMBL28543736 | 0.81 | NPC1 (0.65) | KLK1KLK5HSD17B10PKMRAB9A | |
| SCHEMBL30619961 | 0.81 | NPC1 (0.65) | KLK1KLK5HSD17B10PKMRAB9A | |
| SCHEMBL4454948 | 0.80 | KLK1 (0.63) | KLK1KLK5HSD17B10PKMRAB9A | |
| SCHEMBL7447468 | 0.79 | TGFBR1 (0.46) | KLK1KLK5HSD17B10RAB9ANPC1 | |
| Hydrochloric Acid SCHEMBL10508401 | 0.78 | HSD17B10 (0.61) | KLK1KLK5HSD17B10PKMRAB9A | |
| SCHEMBL7265526 | 0.78 | GAA (0.69) | PKMRAB9ANPC1LMNADDAH1 | |
| SCHEMBL21174657 | 0.77 | KDM4E (0.59) | HSD17B10RAB9ANPC1MAPTLMNA | |
| SCHEMBL5562229 | 0.76 | KLK1 (0.77) | KLK1KLK5HSD17B10PKMRAB9A | |
| SCHEMBL1268891 | 0.76 | KLK1 (1.00) | KLK1KLK5HSD17B10PKMRAB9A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 37 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3177605-B1 | METHOD FOR PRODUCING DABIGATRAN ETEXILATE METHANESULPHONATE | BOEHRINGER INGELHEIM INT (DE) | 2019-03-27 | — | — | EP | disclosed |
| EP-3177605-A1 | METHOD FOR PRODUCING DABIGATRAN ETEXILATE METHANESULPHONATE | Boehringer Ingelheim International GmbH (DE) | 2017-06-14 | — | — | EP | disclosed |
| US-9546154-B2 | Method for producing dabigatran etexilate methansulphonate | BOEHRINGER INGELHEIM INTERNATIONAL GMBH (DE) | 2017-01-17 | — | — | US | disclosed |
| US-20160039791-A1 | METHOD FOR PRODUCING DABIGATRAN ETEXILATE METHANSULPHONATE | BOEHRINGER INGELHEIM INTERNATIONAL GMBH (DE) | 2016-02-11 | — | — | US | disclosed |
| WO-2016020471-A1 | METHOD FOR PRODUCING DABIGATRAN ETEXILATE METHANESULPHONATE | BOEHRINGER INGELHEIM INTERNATIONAL GMBH (DE) | 2016-02-11 | — | — | WO | disclosed |
| US-9212166-B2 | Process for the preparation of dabigatran etexilate mesylate and polymorphs of intermediates thereof | CADILA HEALTHCARE LIMITED (IN) | 2015-12-15 | — | — | US | disclosed |
| EP-1761510-B1 | METHOD FOR PRODUCING 4-(BENZIMIDAZOLYLMETHYLAMINO)-BENZAMIDINES | BOEHRINGER INGELHEIM INT (DE) | 2015-05-13 | — | — | EP | disclosed |
| US-8993770-B2 | Process for the manufacture of dabigatran etexilate | BOEHRINGER INGELHEIM INTERNATIONAL GBMH (DE) | 2015-03-31 | — | — | US | disclosed |
| EP-2297132-B1 | METHOD FOR MANUFACTURING AN INTERMEDIARY PRODUCT OF DABIGATRAN ETEXILATE | BOEHRINGER INGELHEIM INT (DE) | 2015-02-25 | — | — | EP | disclosed |
| US-20150011589-A1 | PROCESS FOR THE PREPARATION OF DABIGATRAN ETEXILATE MESYLATE AND POLYMORPHS OF INTERMEDIATES THEREOF | CADILA HEALTHCARE LIMITED (IN) | 2015-01-08 | — | — | US | disclosed |
| US-20070185173-A1 | Process for the Preparation of the Salts of 4-(Benzimidazolylmethylamino)-Benzamides | BOEHRINGER INGELHEIM INTERNATIONAL GMBH (DE) | 2007-08-09 | — | — | US | disclosed |
| US-20070185333-A1 | Process for the Preparation of 4-(Benzimidazolylmethylamino)-Benzamides and the Salts Thereof | BOEHRINGER INGELHEIM INTERNATIONAL GMBH (DE) | 2007-08-09 | — | — | US | disclosed |
| WO-2007071742-A1 | IMPROVED PROCESS FOR THE PREPARATION OF 4-(BENZIMIDAZOLYLMETHYLAMINO)-BENZAMIDES AND THE SALTS THEREOF | BOEHRINGER INGELHEIM INTERNATIONAL GMBH (DE) | 2007-06-28 | — | — | WO | disclosed |
| WO-2007071743-A1 | IMPROVED PROCESS FOR THE PREPARATION OF THE SALTS OF 4-(BENZIMIDAZOLYLMETHYLAMINO)-BENZAMIDES | BOEHRINGER INGELHEIM INTERNATIONAL GMBH (DE) | 2007-06-28 | — | — | WO | disclosed |
| US-20070149589-A1 | Process for the Preparation of 4-(benzimidazolylmethylamino)benzamidines | BOEHRINGER INGELHEIM INTERNATIONAL GMBH (DE) | 2007-06-28 | — | — | US | disclosed |
| US-7202368-B2 | Process for the preparation of 4-(benzimidazolymethylamino) benzamidines | BOEHRINGER INGELHEIM INTERNATIONAL GMBH (DE) | 2007-04-10 | — | — | US | disclosed |
| EP-1761510-A1 | METHOD FOR PRODUCING 4-(BENZIMIDAZOLYLMETHYLAMINO)-BENZAMIDINES | BOEHRINGER INGELHEIM INTERNATIONAL GMBH (DE) | 2007-03-14 | — | — | EP | disclosed |
| US-20060004064-A1 | Process for the preparation of 4-(benzimidazolymethylamino) benzamidines | BOEHRINGER INGELHEIM INTERNATIONAL GMBH (DE) | 2006-01-05 | — | — | US | disclosed |
| WO-2006000353-A1 | METHOD FOR PRODUCING 4-(BENZIMIDAZOLYLMETHYLAMINO)-BENZAMIDINES | BOEHRINGER INGELHEIM INTERNATIONAL GMBH (DE) | 2006-01-05 | — | — | WO | disclosed |
| EP-1609784-A1 | Process for the preparation of 4-(benzimidazolylmethylamino)-benzamidines | Boehringer Ingelheim Pharma GmbH & Co.KG (DE) | 2005-12-28 | — | — | EP | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (6 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20070149589-A1 | Process for the Preparation of 4-(benzimidazolylmethylamino)benzamidines | DDC, PDK2, ACMSD | KLK1 1162/4885KLK5 908/4885HSD17B10 689/4885 |
| US-20070185173-A1 | Process for the Preparation of the Salts of 4-(Benzimidazolylmethylamino)-Benzamides | DDC, BCKDK, IL4I1 | KLK1 1440/4885KLK5 443/4885HSD17B10 805/4885 |
| US-20070185333-A1 | Process for the Preparation of 4-(Benzimidazolylmethylamino)-Benzamides and the Salts Thereof | DDC, BCKDK, ODC1 | KLK1 1611/4885KLK5 648/4885HSD17B10 709/4885 |
| US-20150011589-A1 | PROCESS FOR THE PREPARATION OF DABIGATRAN ETEXILATE MESYLATE AND POLYMORPHS OF INTERMEDIATES THEREOF | CYP1A2, CYP3A4, CYP2C9 | KLK1 3876/4885KLK5 2686/4885HSD17B10 911/4885 |
| US-20060004064-A1 | Process for the preparation of 4-(benzimidazolymethylamino) benzamidines | DDC, PDK2, ACMSD | KLK1 1019/4885KLK5 763/4885HSD17B10 618/4885 |
| US-20160039791-A1 | METHOD FOR PRODUCING DABIGATRAN ETEXILATE METHANSULPHONATE | VKORC1, VKORC1L1, MPST | KLK1 2395/4885KLK5 3228/4885HSD17B10 904/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.