Biotin

Biotin

SCHEMBL1269621

Nc1ccc(C(=O)O)cc1.O=C(O)CCCC[C@@H]1SC[C@@H]2NC(=O)N[C@@H]21.[NaH]

nearest known ligand 0.72

Full drug profile on Sugi Atlas →

Predicted protein targets (top 15)

geneUniProtsupporting neighboursconfidence
▸ TDP1 Q9NUW8 6/20 0.72
▸ MEN1 O00255 1/20 0.72
▸ ABL1 P00519 1/20 0.72
▸ LMNA P02545 1/20 0.72
▸ PKM P14618 1/20 0.72
▸ IDE P14735 1/20 0.72
▸ MAPK1 P28482 1/20 0.72
▸ KMT2A Q03164 1/20 0.72
▸ RIN1 Q13671 1/20 0.72
▸ L3MBTL1 Q9Y468 1/20 0.72
▸ HLCS P50747 4/20 0.52
▸ CA12 O43570 8/20 0.52
▸ CA1 P00915 8/20 0.52
▸ CA2 P00918 8/20 0.52
▸ CA9 Q16790 8/20 0.52

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
Biotin SCHEMBL438197 0.99 TDP1 (0.74) TDP1MEN1ABL1LMNAPKM
Biotin SCHEMBL2484400 0.90 TDP1 (0.69) TDP1MEN1ABL1LMNAPKM
Biotin SCHEMBL1269623 0.90 TDP1 (0.60) TDP1MEN1ABL1LMNAPKM
Biotin SCHEMBL3378125 0.89 TDP1 (0.79) TDP1MEN1ABL1LMNAPKM
Biotin SCHEMBL3142794 0.86 TDP1 (0.71) TDP1MEN1ABL1LMNAPKM
Biotin SCHEMBL6930604 0.86 TDP1 (0.97) TDP1MEN1ABL1LMNAPKM
Biotin SCHEMBL723192 0.85 TDP1 (0.90) TDP1MEN1ABL1LMNAPKM
Biotin SCHEMBL1199492 0.85 TDP1 (0.94) TDP1MEN1ABL1LMNAPKM
Biotin SCHEMBL636444 0.85 TDP1 (0.94) TDP1MEN1ABL1LMNAPKM
Biotin SCHEMBL23055065 0.85 TDP1 (1.00) TDP1MEN1ABL1LMNAPKM

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 99 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-20240139288-A1 LIPID-BASED NANOPARTICLES AND USE OF SAME IN OPTIMIZED INSULIN DOSING REGIMENS SDG INC (US) 2024-05-02 — — US claimed
US-20240108585-A1 COMPOSITIONS COMPRISING LIPID-BASED NANOPARTICLES FOR TREATING DIABETES MELLITUS SDG, INC. 2024-04-04 — — US claimed
EP-2552202-B1 METHODS AND COMPOSITIONS FOR WEIGHT LOSS SDG INC (US) 2023-07-26 — — EP claimed
US-20230172868-A1 LIPID-BASED NANOPARTICLES WITH ENHANCED STABILITY SDG, INC. (US) 2023-06-08 — — US claimed
US-11517529-B2 Orally bioavailable lipid-based constructs SDG, INC. (US) 2022-12-06 — — US claimed
EP-3952904-A1 LIPID-BASED NANOPARTICLES AND USE OF SAME IN OPTIMIZED INSULIN DOSING REGIMENS SDG, Inc. (US) 2022-02-16 — — EP claimed
US-20210379160-A1 LIPID-BASED NANOPARTICLES AND USE OF SAME IN OPTIMIZED INSULIN DOSING REGIMENS SDG INC (US) 2021-12-09 — — US claimed
US-11077173-B2 Lipid-based nanoparticles and methods using same SDG, INC. (US) 2021-08-03 — — US claimed
US-11071715-B2 Lipid-based nanoparticles and methods using same SDG, INC. (US) 2021-07-27 — — US claimed
US-20210137838-A1 LIPID-BASED NANOPARTICLES WITH ENHANCED STABILITY SDG, INC. 2021-05-13 — — US claimed
US-20100310599-A1 Orally Bioavailable Lipid-Based Constructs SDG, INC. 2010-12-09 — — US claimed
US-20100247625-A1 Orally Bioavailable Lipid-Based Constructs SDG, INC. 2010-09-30 — — US claimed
EP-2205217-A1 ORALLY BIOAVAILABLE LIPID-BASED CONSTRUCTS SDG, INC. (an Ohio Corporation ) (US) 2010-07-14 — — EP claimed
US-20100129428-A1 SUPRA MOLECULAR CONSTRUCT FOR DELIVERY OF INTERFERON TO A MAMMAL SDG, INC. 2010-05-27 — — US claimed
US-20090087479-A1 Orally bioavailable lipid-based constructs SDG, INC. ( AN OHIO CORPORATION) (US) 2009-04-02 — — US claimed
WO-2009042945-A1 ORALLY BIOAVAILABLE LIPID-BASED CONSTRUCTS SDG, INC. (AN OHIO CORPORATION ) (US) 2009-04-02 — — WO claimed
EP-1883394-A2 LIPID CONSTRUCT FOR DELIVERY OF INSULIN TO A MAMMAL SDG, Inc. (US) 2008-02-06 — — EP claimed
EP-1883395-A2 LIPID CONSTRUCT FOR DELIVERY OF INTERFERON TO A MAMMAL SDG, Inc. (US) 2008-02-06 — — EP claimed
WO-2006127361-A2 LIPID CONSTRUCT FOR DELIVERY OF INSULIN TO A MAMMAL SDG, INC. (US) 2006-11-30 — — WO claimed
WO-2006127360-A2 LIPID CONSTRUCT FOR DELIVERY OF INTERFERON TO A MAMMAL SDG, INC. (US) 2006-11-30 — — WO claimed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (12 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20210379160-A1 LIPID-BASED NANOPARTICLES AND USE OF SAME IN OPTIMIZED INSULIN DOSING REGIMENS PNLIP, IAPP, LIPC TDP1 4800/4885MEN1 561/4885ABL1 2416/4885
US-20100129428-A1 SUPRA MOLECULAR CONSTRUCT FOR DELIVERY OF INTERFERON TO A MAMMAL HAVCR2, IFNAR1, IFNG TDP1 4713/4885MEN1 4095/4885ABL1 2883/4885
US-20240108585-A1 COMPOSITIONS COMPRISING LIPID-BASED NANOPARTICLES FOR TREATING DIABETES MELLITUS IAPP, PNLIP, LIPC TDP1 4738/4885MEN1 1515/4885ABL1 2221/4885
US-20100310599-A1 Orally Bioavailable Lipid-Based Constructs FABP2, LIPC, FABP6 TDP1 4650/4885MEN1 1077/4885ABL1 3190/4885
US-20230172868-A1 LIPID-BASED NANOPARTICLES WITH ENHANCED STABILITY LIPA, NPC1L1, PLIN3 TDP1 3561/4885MEN1 1725/4885ABL1 2117/4885
US-11517529-B2 Orally bioavailable lipid-based constructs FABP2, FABP1, FABP6 TDP1 4819/4885MEN1 966/4885ABL1 4375/4885
US-11077173-B2 Lipid-based nanoparticles and methods using same LIPA, PLIN3, CETP TDP1 2457/4885MEN1 2345/4885ABL1 1844/4885
US-20090087479-A1 Orally bioavailable lipid-based constructs FABP2, FABP1, FABP6 TDP1 4757/4885MEN1 1343/4885ABL1 3225/4885
US-20210137838-A1 LIPID-BASED NANOPARTICLES WITH ENHANCED STABILITY LIPA, NPC1L1, PLIN3 TDP1 3561/4885MEN1 1725/4885ABL1 2117/4885
US-11071715-B2 Lipid-based nanoparticles and methods using same LIPA, PLIN3, CETP TDP1 2457/4885MEN1 2345/4885ABL1 1844/4885
US-20100247625-A1 Orally Bioavailable Lipid-Based Constructs FABP2, LIPC, FABP6 TDP1 4650/4885MEN1 1077/4885ABL1 3190/4885
US-20240139288-A1 LIPID-BASED NANOPARTICLES AND USE OF SAME IN OPTIMIZED INSULIN DOSING REGIMENS PNLIP, IAPP, LIPC TDP1 4800/4885MEN1 561/4885ABL1 2416/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.

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