Known targets — ChEMBL curated mechanism
CACNA1CCACNA1DCACNA1FCACNA1SDPP4HTR1BHTR1D
The experimentally established mechanism targets of Biotin. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TDP1 | Q9NUW8 | 6/20 | 0.79 |
| ▸ | MEN1 | O00255 | 1/20 | 0.79 |
| ▸ | ABL1 | P00519 | 1/20 | 0.79 |
| ▸ | LMNA | P02545 | 1/20 | 0.79 |
| ▸ | PKM | P14618 | 1/20 | 0.79 |
| ▸ | IDE | P14735 | 1/20 | 0.79 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.79 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.79 |
| ▸ | RIN1 | Q13671 | 1/20 | 0.79 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.79 |
| ▸ | HLCS | P50747 | 6/20 | 0.56 |
| ▸ | CA12 | O43570 | 7/20 | 0.55 |
| ▸ | CA1 | P00915 | 7/20 | 0.55 |
| ▸ | CA2 | P00918 | 7/20 | 0.55 |
| ▸ | CA9 | Q16790 | 7/20 | 0.55 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Biotin SCHEMBL18993019 | 0.91 | TDP1 (0.83) | TDP1MEN1ABL1LMNAPKM | |
| Biotin SCHEMBL438197 | 0.90 | TDP1 (0.74) | TDP1MEN1ABL1LMNAPKM | |
| Biotin SCHEMBL23124079 | 0.89 | TDP1 (0.81) | TDP1MEN1ABL1LMNAPKM | |
| Biotin SCHEMBL723192 | 0.89 | TDP1 (0.90) | TDP1MEN1ABL1LMNAPKM | |
| Biotin SCHEMBL4624640 | 0.89 | TDP1 (0.72) | TDP1MEN1ABL1LMNAPKM | |
| Biotin SCHEMBL1269621 | 0.89 | TDP1 (0.72) | TDP1MEN1ABL1LMNAPKM | |
| Biotin SCHEMBL22943835 | 0.89 | TDP1 (1.00) | TDP1MEN1ABL1LMNAPKM | |
| Biotin SCHEMBL21981206 | 0.89 | TDP1 (1.00) | TDP1MEN1ABL1LMNAPKM | |
| Biotin SCHEMBL20547409 | 0.89 | TDP1 (1.00) | TDP1MEN1ABL1LMNAPKM | |
| Biotin SCHEMBL14489489 | 0.89 | TDP1 (1.00) | TDP1MEN1ABL1LMNAPKM |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 25 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-9528106-B2 | In vitro sorting method | MEDICAL RESEARCH COUNCIL (GB) | 2016-12-27 | — | — | US | disclosed |
| US-20130190189-A1 | IN VITRO SORTING METHOD | MEDICAL RESEARCH COUNCIL (GB) | 2013-07-25 | — | — | US | disclosed |
| US-8367326-B2 | In vitro sorting method | MEDICAL RESEARCH COUNCIL (GB) | 2013-02-05 | — | — | US | disclosed |
| EP-1908832-B1 | A method for increasing the concentration of a nucleic acid molecule | MEDICAL RES COUNCIL (GB) | 2012-12-26 | — | — | EP | disclosed |
| EP-2258846-A2 | A method for increasing the concentration of a nucleic acid molecule | MEDICAL RESEARCH COUNCIL (GB) | 2010-12-08 | — | — | EP | disclosed |
| EP-1801214-B1 | In vitro sorting method | MEDICAL RES COUNCIL (GB) | 2010-11-10 | — | — | EP | disclosed |
| US-7638276-B2 | In vitro sorting method | 454 LIFE SCIENCES CORPORATION (US) | 2009-12-29 | — | — | US | disclosed |
| US-7582446-B2 | In vitro sorting method | MEDICAL RESEARCH COUNCIL (GB) | 2009-09-01 | — | — | US | disclosed |
| EP-1908832-A2 | A method for increasing the concentration of a nucleic acid molecule | Medical Research Council (GB) | 2008-04-09 | — | — | EP | disclosed |
| US-20070259374-A1 | In vitro sorting method | MEDICAL RESEARCH COUNCIL (GB) | 2007-11-08 | — | — | US | disclosed |
| US-7138233-B2 | Isolating genetic elements encoding a gene product by separating aqueous droplets containing the same | MEDICAL RESEARCH COUNCIL (GB) | 2006-11-21 | — | — | US | disclosed |
| US-20050069920-A1 | Using encapuslated gene sequences as tools for directed evolution of nucleic acids; microencapsulation and gene expression | UNITED KINGDOM RESEARCH AND INNOVATION (GB) | 2005-03-31 | — | — | US | disclosed |
| US-20050042648-A1 | Vitro sorting method | UNITED KINGDOM RESEARCH AND INNOVATION (GB) | 2005-02-24 | — | — | US | disclosed |
| EP-1496120-A2 | In vitro sorting method | Medical Research Council (GB) | 2005-01-12 | — | — | EP | disclosed |
| EP-1482036-A2 | A method for increasing the concentration of a nucleic acid molecule | MEDICAL RESEARCH COUNCIL (GB) | 2004-12-01 | — | — | EP | disclosed |
| EP-1019496-B1 | IN VITRO SORTING METHOD | MEDICAL RES COUNCIL (GB) | 2004-09-29 | — | — | EP | disclosed |
| US-20030124586-A1 | Isolating genetic elements encoding a gene product by separating aqueous droplets containing the same | UNITED KINGDOM RESEARCH AND INNOVATION (GB) | 2003-07-03 | — | — | US | disclosed |
| US-6489103-B1 | ISOLATING ONE OR MORE GENETIC ELEMENTS ENCODING A GENE PRODUCT COMPARTMENTALISING GENETIC ELEMENTS INTO MICROCAPSULES; (B) EXPRESSING THE GENETIC ELEMENTS TO PRODUCE THEIR RESPECTIVE GENE PRODUCTS AND SORTING GENETIC ELEMENTS | MEDICAL RESEARCH COUNCIL (GB) | 2002-12-03 | — | — | US | disclosed |
| EP-1019496-A1 | IN VITRO SORTING METHOD | MEDICAL RESEARCH COUNCIL (GB) | 2000-07-19 | — | — | EP | disclosed |
| WO-1999002671-A1 | IN VITRO SORTING METHOD | MEDICAL RESEARCH COUNCIL (GB) | 1999-01-21 | — | — | WO | disclosed |