Biotin

Biotin

SCHEMBL438197

Nc1ccc(C(=O)O)cc1.O=C(O)CCCC[C@@H]1SC[C@@H]2NC(=O)N[C@@H]21

nearest known ligand 0.74

Full drug profile on Sugi Atlas →

Predicted protein targets (top 15)

geneUniProtsupporting neighboursconfidence
▸ TDP1 Q9NUW8 6/20 0.74
▸ MEN1 O00255 1/20 0.74
▸ ABL1 P00519 1/20 0.74
▸ LMNA P02545 1/20 0.74
▸ PKM P14618 1/20 0.74
▸ IDE P14735 1/20 0.74
▸ MAPK1 P28482 1/20 0.74
▸ KMT2A Q03164 1/20 0.74
▸ RIN1 Q13671 1/20 0.74
▸ L3MBTL1 Q9Y468 1/20 0.74
▸ HLCS P50747 4/20 0.53
▸ CA12 O43570 8/20 0.52
▸ CA1 P00915 8/20 0.52
▸ CA2 P00918 8/20 0.52
▸ CA9 Q16790 8/20 0.52

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
Biotin SCHEMBL1269621 0.99 TDP1 (0.72) TDP1MEN1ABL1LMNAPKM
Biotin SCHEMBL1269623 0.91 TDP1 (0.60) TDP1MEN1ABL1LMNAPKM
Biotin SCHEMBL2484400 0.91 TDP1 (0.69) TDP1MEN1ABL1LMNAPKM
Biotin SCHEMBL3378125 0.90 TDP1 (0.79) TDP1MEN1ABL1LMNAPKM
Biotin SCHEMBL3142794 0.87 TDP1 (0.71) TDP1MEN1ABL1LMNAPKM
Biotin SCHEMBL723192 0.86 TDP1 (0.90) TDP1MEN1ABL1LMNAPKM
Biotin SCHEMBL1199492 0.86 TDP1 (0.94) TDP1MEN1ABL1LMNAPKM
Biotin SCHEMBL636444 0.86 TDP1 (0.94) TDP1MEN1ABL1LMNAPKM
Biotin SCHEMBL23055065 0.86 TDP1 (1.00) TDP1MEN1ABL1LMNAPKM
Biotin SCHEMBL21981206 0.86 TDP1 (1.00) TDP1MEN1ABL1LMNAPKM

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 194 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
WO-2024077174-A1 METHODS FOR CULTURING NR4A-DEFICIENT CELLS LYELL IMMUNOPHARMA, INC. (US) 2024-04-11 — — WO disclosed
WO-2023147185-A9 METHODS FOR MAKING AND USING ANTIGEN-PRESENTING CELL-MIMETIC SCAFFOLDS TO ENHANCE T-CELL THERAPIES PRESIDENT AND FELLOWS OF HARVARD COLLEGE (US) 2024-01-04 — — WO disclosed
US-20230357313-A1 SERUM RESISTANT BIS-SULFHYDRYL SPECIFIC BIOTINYLATION REAGENT Miltenyi Biotec B.V. & Co. KG (DE) 2023-11-09 — — US disclosed
US-20230340404-A1 ANTIGEN-PRESENTING CELL-MIMETIC SCAFFOLDS AND METHODS FOR MAKING AND USING THE SAME PRESIDENT AND FELLOWS OF HARVARD COLLEGE (US) 2023-10-26 — — US disclosed
EP-4234559-A1 SERUM RESISTANT BIS-SULFHYDRYL SPECIFIC BIOTINYLATION REAGENT Miltenyi Biotec B.V. & Co. KG (DE) 2023-08-30 — — EP disclosed
CN-116640151-A Serum-resistant dimercapto-specific biotinylation reagent 美天施生物科技有限两合公司 2023-08-25 — — CN disclosed
WO-2023147185-A1 METHODS FOR MAKING AND USING ANTIGEN-PRESENTING CELL-MIMETIC SCAFFOLDS TO ENHANCE T-CELL THERAPIES PRESIDENT AND FELLOWS OF HARVARD COLLEGE (US) 2023-08-03 — — WO disclosed
US-20230181644-A1 METHODS OF GENERATING CELLS LYELL IMMUNOPHARMA, INC. (US) 2023-06-15 — — US disclosed
WO-2023076511-A1 METHODS OF GENERATING CELLS LYELL IMMUNOPHARMA, INC. (US) 2023-05-04 — — WO disclosed
US-11555177-B2 Antigen-presenting cell-mimetic scaffolds and methods for making and using the same PRESIDENT AND FELLOWS OF HARVARD COLLEGE (US) 2023-01-17 — — US disclosed
US-5690907-A Avidin-biotin conjugated emulsions as a site specific binding system THE JEWISH HOSPITAL OF ST. LOUIS (US) 1997-11-25 — — US disclosed
EP-0544759-B1 DETOXIFICATION OF SOIL YAMASHITA THOMAS T (US) 1997-07-30 — — EP disclosed
WO-1996041647-A1 SITE SPECIFIC BINDING SYSTEM, IMAGING COMPOSITIONS AND METHODS BARNES-JEWISH HOSPITAL D/B/A (US) 1996-12-27 — — WO disclosed
US-5582627-A TREATMENT OF SOIL CONTAMINATED WITH HERBICIDES AND PESTICIDES COMPRISING ADDING NUTRIENT MEDIUM, COMPLEXING MEDIUM, NITROGEN AND PHOSPHORUS NUTRIENTS YAMASHITA THOMAS T (US) 1996-12-10 — — US disclosed
US-5549729-A CONSISTS OF CARBON SKELETON/ENERGY COMPONENT, MACRONUTRIENT COMPONENT AND VITAMIN/COFACTOR COMPONENT; SUITABLE FOR FOLIAR SPRAYS YAMASHITA THOMAS T (US) 1996-08-27 — — US disclosed
EP-0433394-B1 METHOD OF APPLYING ENERGY, CARBON SKELETON AND NUTRIENT MATERIALSTO VEGETATION YAMASHITA THOMAS T (US) 1995-11-08 — — EP disclosed
EP-0544759-A4 DETOXIFICATION OF SOIL YAMASHITA THOMAS T (US) 1994-06-01 — — EP disclosed
EP-0544759-A1 DETOXIFICATION OF SOIL. YAMASHITA THOMAS T (US) 1993-06-09 — — EP disclosed
WO-1992003393-A1 DETOXIFICATION OF SOIL YAMASHITA THOMAS T (US) 1992-03-05 — — WO disclosed
WO-1991013844-A1 METHOD AND COMPOSITION FOR PROMOTING AND CONTROLLING GROWTH OF PLANTS YAMASHITA THOMAS T (US) 1991-09-19 — — WO disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20230357313-A1 SERUM RESISTANT BIS-SULFHYDRYL SPECIFIC BIOTINYLATION REAGENT BTD, HLCS, CBS TDP1 4782/4885MEN1 3517/4885ABL1 1840/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.

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