Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | C5AR1 | P21730 | 8/20 | 0.42 |
| ▸ | GPX4 | P36969 | 1/20 | 0.36 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.35 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.34 |
| ▸ | HPGD | P15428 | 1/20 | 0.34 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.34 |
| ▸ | MEN1 | O00255 | 1/20 | 0.34 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.34 |
| ▸ | MAPT | P10636 | 2/20 | 0.34 |
| ▸ | POLB | P06746 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL14788390 | 0.81 | GPX4 (0.54) | C5AR1GPX4ALDH1A1KDM4ESMN1; SMN2 | |
| SCHEMBL14788457 | 0.74 | C5AR1 (0.45) | C5AR1ALDH1A1KDM4ESMN1; SMN2MEN1 | |
| SCHEMBL29864762 | 0.71 | GPX4 (0.49) | C5AR1GPX4ALDH1A1SMN1; SMN2MEN1 | |
| SCHEMBL14788388 | 0.71 | GPX4 (0.49) | C5AR1GPX4ALDH1A1SMN1; SMN2MEN1 | |
| SCHEMBL27264728 | 0.71 | GPX4 (0.70) | C5AR1GPX4ALDH1A1SMN1; SMN2MEN1 | |
| SCHEMBL14788327 | 0.67 | LMNA (0.47) | GPX4ALDH1A1SMN1; SMN2KMT2AMAPT | |
| SCHEMBL12639686 | 0.67 | POLB (0.53) | GPX4SMN1; SMN2MEN1KMT2AMAPT | |
| SCHEMBL14788385 | 0.65 | CYP1A2 (0.49) | GPX4SMN1; SMN2MEN1KMT2AMAPT | |
| SCHEMBL14788325 | 0.64 | ALDH1A1 (0.46) | ALDH1A1KDM4ESMN1; SMN2MEN1KMT2A | |
| SCHEMBL14788609 | 0.61 | GAA (0.43) | ALDH1A1HPGDSMN1; SMN2MEN1KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2012129452-A2 | PROPYNOIC ACID CARBAMOYL METHYL-ALMIDES AND PHARMACEUTICAL COMPOSITIONS AND METHODS BASED THEREON | UNIVERSITY OF SOUTHERN CALIFORNIA (US) | 2012-09-27 | — | — | WO | disclosed |