SCHEMBL1269987

SCHEMBL1269987

Oc1cnc2ccoc2c1

nearest known ligand 0.45

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
FTO Q9C0B1 1/20 0.40
DYRK1A Q13627 2/20 0.36
MAP4K4 O95819 1/20 0.36
CDK8 P49336 1/20 0.36
CLK2 P49760 1/20 0.36
CDK7 P50613 1/20 0.36
CDK9 P50750 1/20 0.36
CDK5 Q00535 1/20 0.36
ACVR1 Q04771 1/20 0.36
ROCK1 Q13464 1/20 0.36
LRRK2 Q5S007 1/20 0.36
CLK4 Q9HAZ1 1/20 0.36
DYRK1B Q9Y463 1/20 0.36
SNCA P37840 2/20 0.34
ESR2 Q92731 4/20 0.34
ESR1 P03372 3/20 0.34
PDE4B Q07343 1/20 0.32
PDE4D Q08499 1/20 0.32
LMNA P02545 2/20 0.31
MAPT P10636 2/20 0.31

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL457106 0.75 DYRK1A (0.38) DYRK1APDE4BPDE4DMAPTALDH1A1
SCHEMBL31168602 0.75 TRPA1 (0.34) DYRK1APDE4BPDE4DIRAK4PDE4A
SCHEMBL13459982 0.75 DYRK1A (0.40) DYRK1AMAP4K4CDK9PDE4BPDE4D
SCHEMBL31168473 0.75 CYP1A2 (0.44) DYRK1ALMNAMAPTKDM4EALDH1A1
SCHEMBL827713 0.75 CYP1A2 (0.44) DYRK1ALMNAMAPTKDM4EALDH1A1
SCHEMBL24655972 0.75 DYRK1A (0.33) DYRK1APDE4BPDE4DIRAK4PDE4A
SCHEMBL3802865 0.75 RECQL (0.36) DYRK1APDE4BPDE4DLMNAHSD17B10
SCHEMBL14665437 0.75 ENPP2 (0.35) DYRK1APDE4BPDE4D
SCHEMBL9694126 0.73 MGAM (0.50) FTOMAPTKDM4EALDH1A1HSD17B10
SCHEMBL31133349 0.73 MGAM (0.50) FTOMAPTKDM4EALDH1A1HSD17B10

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 26 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-3704094-B1 MODULATORS OF THE INTEGRATED STRESS PATHWAY CALICO LIFE SCIENCES LLC (US) 2026-03-11 EP disclosed
US-20250122188-A1 MODULATORS OF THE INTEGRATED STRESS PATHWAY CALICO LIFE SCIENCES LLC (US) 2025-04-17 US disclosed
US-20250115563-A1 MODULATORS OF THE INTEGRATED STRESS PATHWAY CALICO LIFE SCIENCES LLC 2025-04-10 US disclosed
US-20240166652-A1 MODULATORS OF THE INTEGRATED STRESS PATHWAY ABBVIE INC. 2024-05-23 US disclosed
EP-4356971-A2 MODULATORS OF THE INTEGRATED STRESS PATHWAY Calico Life Sciences LLC (US) 2024-04-24 EP disclosed
EP-3704098-B1 MODULATORS OF THE INTEGRATED STRESS PATHWAY CALICO LIFE SCIENCES LLC (US) 2024-01-24 EP disclosed
US-20230144871-A1 MODULATORS OF THE INTEGRATED STRESS PATHWAY ABBVIE INC. 2023-05-11 US disclosed
US-20220363678-A1 MODULATORS OF THE INTEGRATED STRESS PATHWAY CALICO LIFE SCIENCES LLC (US) 2022-11-17 US disclosed
US-20210113532-A1 MODULATORS OF THE INTEGRATED STRESS PATHWAY CALICO LIFE SCIENCES LLC (US) 2021-04-22 US disclosed
EP-3778575-A1 MODULATORS OF THE INTEGRATED STRESS PATHWAY Calico Life Sciences LLC (US) 2021-02-17 EP disclosed
EP-3190888-B1 PROBES FOR IMAGING HUNTINGTIN PROTEIN CHDI FOUNDATION INC (US) 2020-06-10 EP disclosed
EP-3190888-B1 PROBES FOR IMAGING HUNTINGTIN PROTEIN CHDI FOUNDATION INC (US) 2020-06-10 EP disclosed
US-20190144440-A1 MODULATORS OF THE INTEGRATED STRESS PATHWAY ABBVIE INC. 2019-05-16 US disclosed
US-20190142806-A1 MODULATORS OF THE INTEGRATED STRESS PATHWAY ABBVIE INC. 2019-05-16 US disclosed
US-20170292150-A1 PROBES FOR IMAGING HUNTINGTIN PROTEIN CHDI FOUNDATION, INC. 2017-10-12 US disclosed
US-20170292150-A1 PROBES FOR IMAGING HUNTINGTIN PROTEIN CHDI FOUNDATION, INC. 2017-10-12 US disclosed
US-20170292150-A1 PROBES FOR IMAGING HUNTINGTIN PROTEIN CHDI FOUNDATION, INC. 2017-10-12 US disclosed
WO-2016033460-A1 PROBES FOR IMAGING HUNTINGTIN PROTEIN CHDI FOUNDATION, INC. (US) 2016-03-03 WO disclosed
US-9149465-B2 Isoxazolines as inhibitors of fatty acid amide hydrolase INFINITY PHARMACEUTICALS, INC. (US) 2015-10-06 US disclosed
US-20110028478-A1 ISOXAZOLINES AS INHIBITORS OF FATTY ACID AMIDE HYDROLASE INFINITY PHARMACEUTICALS, INC. (US) 2011-02-03 US disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (10 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20110028478-A1 ISOXAZOLINES AS INHIBITORS OF FATTY ACID AMIDE HYDROLASE FAAH, FAAH2, HRH2 FTO 1258/4885DYRK1A 3331/4885MAP4K4 4073/4885
US-20190142806-A1 MODULATORS OF THE INTEGRATED STRESS PATHWAY ATF4, ATF1, DDIT3 FTO 4159/4885DYRK1A 2901/4885MAP4K4 195/4885
US-20190144440-A1 MODULATORS OF THE INTEGRATED STRESS PATHWAY ATF4, ATF1, DDIT3 FTO 4159/4885DYRK1A 2901/4885MAP4K4 195/4885
US-20250122188-A1 MODULATORS OF THE INTEGRATED STRESS PATHWAY ATF4, ATF1, DDIT3 FTO 4159/4885DYRK1A 2901/4885MAP4K4 195/4885
US-20230144871-A1 MODULATORS OF THE INTEGRATED STRESS PATHWAY ATF4, ATF1, DDIT3 FTO 4159/4885DYRK1A 2901/4885MAP4K4 195/4885
US-20210113532-A1 MODULATORS OF THE INTEGRATED STRESS PATHWAY ATF4, ATF1, DDIT3 FTO 4159/4885DYRK1A 2901/4885MAP4K4 195/4885
US-20240166652-A1 MODULATORS OF THE INTEGRATED STRESS PATHWAY ATF4, ATF1, DDIT3 FTO 4159/4885DYRK1A 2901/4885MAP4K4 195/4885
US-20220363678-A1 MODULATORS OF THE INTEGRATED STRESS PATHWAY ATF4, ATF1, DDIT3 FTO 4159/4885DYRK1A 2901/4885MAP4K4 195/4885
US-20250115563-A1 MODULATORS OF THE INTEGRATED STRESS PATHWAY ATF4, ATF1, DDIT3 FTO 4159/4885DYRK1A 2901/4885MAP4K4 195/4885
US-20170292150-A1 PROBES FOR IMAGING HUNTINGTIN PROTEIN HTT, HYPK, FABP7 FTO 4199/4885DYRK1A 4251/4885MAP4K4 3870/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.