SCHEMBL12705244

SCHEMBL12705244

O=C(OCCOC12CC3CC(C1)CC(c1ccccc1)(C3)C2)C(F)F

nearest known ligand 0.46

Predicted protein targets (top 19)

geneUniProtsupporting neighboursconfidence
LMNA P02545 2/20 0.46
GRIN2D O15399 1/20 0.43
GRIN3B O60391 1/20 0.43
GRIN1 Q05586 1/20 0.43
GRIN2A Q12879 1/20 0.43
GRIN2B Q13224 1/20 0.43
GRIN2C Q14957 1/20 0.43
GRIN3A Q8TCU5 1/20 0.43
HSD11B1 P28845 3/20 0.42
ALDH1A1 P00352 1/20 0.40
DPP8 Q6V1X1 1/20 0.36
DPP9 Q86TI2 1/20 0.36
ESR1 P03372 1/20 0.36
PGR P06401 1/20 0.36
MEN1 O00255 1/20 0.36
KMT2A Q03164 1/20 0.36
HIF1A Q16665 1/20 0.35
EPAS1 Q99814 1/20 0.35
P2RY10 O00398 1/20 0.35

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL12727587 0.81 LMNA (0.41) LMNAGRIN2DGRIN3BGRIN1GRIN2A
SCHEMBL12705236 0.80 GRIN2D (0.46) LMNAGRIN2DGRIN3BGRIN1GRIN2A
SCHEMBL12705115 0.77 ALDH1A1 (0.36) LMNAHSD11B1ALDH1A1
SCHEMBL18557936 0.72 LMNA (0.41) LMNAGRIN2DGRIN3BGRIN1GRIN2A
SCHEMBL27753390 0.72 LMNA (0.50) LMNAGRIN2DGRIN3BGRIN1GRIN2A
SCHEMBL12705340 0.70 ALDH1A1 (0.36) LMNAALDH1A1
SCHEMBL1352813 0.68 GRIN2D (0.75) LMNAGRIN2DGRIN3BGRIN1GRIN2A
SCHEMBL7016818 0.68 GRIN2D (0.44) LMNAGRIN2DGRIN3BGRIN1GRIN2A
SCHEMBL12705419 0.68 KMT2A (0.47) LMNAHSD11B1ALDH1A1MEN1KMT2A
SCHEMBL2253976 0.67 HSD11B1 (0.66) LMNAGRIN2DGRIN3BGRIN1GRIN2A

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-20110091808-A1 PHOTORESIST COMPOSITION SUMITOMO CHEMICAL COMPANY, LIMITED (JP) 2011-04-21 US disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20110091808-A1 PHOTORESIST COMPOSITION ASIC1, ASIC3, SUN2 LMNA 3534/4885GRIN2D 894/4885GRIN3B 1644/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.