Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ENPP2 | Q13822 | 3/20 | 0.57 |
| ▸ | MEN1 | O00255 | 8/20 | 0.56 |
| ▸ | KMT2A | Q03164 | 8/20 | 0.56 |
| ▸ | POLB | P06746 | 6/20 | 0.56 |
| ▸ | CASP3 | P42574 | 2/20 | 0.56 |
| ▸ | SENP8 | Q96LD8 | 2/20 | 0.56 |
| ▸ | SENP7 | Q9BQF6 | 2/20 | 0.56 |
| ▸ | SENP6 | Q9GZR1 | 2/20 | 0.56 |
| ▸ | HSP90AA1 | P07900 | 1/20 | 0.56 |
| ▸ | GAA | P10253 | 1/20 | 0.56 |
| ▸ | USP2 | O75604 | 1/20 | 0.56 |
| ▸ | GALK1 | P51570 | 1/20 | 0.56 |
| ▸ | BLM | P54132 | 1/20 | 0.56 |
| ▸ | PSMD14 | O00487 | 1/20 | 0.55 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.55 |
| ▸ | PPARG | P37231 | 1/20 | 0.54 |
| ▸ | PTPN1 | P18031 | 5/20 | 0.53 |
| ▸ | ACP1 | P24666 | 4/20 | 0.53 |
| ▸ | ATM | Q13315 | 2/20 | 0.53 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.51 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL12712437 | 0.87 | ENPP2 (0.64) | ENPP2MEN1KMT2APOLBCASP3 | |
| SCHEMBL12712450 | 0.87 | ENPP2 (0.52) | ENPP2MEN1KMT2APOLBCASP3 | |
| SCHEMBL12712449 | 0.87 | MEN1 (0.50) | ENPP2MEN1KMT2APOLBCASP3 | |
| SCHEMBL1614533 | 0.84 | NLRP3 (0.55) | ENPP2MEN1KMT2APOLBCASP3 | |
| SCHEMBL15682752 | 0.83 | MEN1 (0.78) | ENPP2MEN1KMT2APOLBCASP3 | |
| SCHEMBL26606767 | 0.83 | MEN1 (0.64) | ENPP2MEN1KMT2APOLBCASP3 | |
| SCHEMBL12712452 | 0.82 | PIM1 (0.50) | MEN1KMT2AALDH1A1PPARG | |
| SCHEMBL12712457 | 0.80 | COMT (0.53) | MEN1KMT2APOLBGAAUSP2 | |
| SCHEMBL3284901 | 0.80 | ENPP2 (0.74) | ENPP2MEN1KMT2APOLBCASP3 | |
| SCHEMBL3284905 | 0.80 | ENPP2 (0.74) | ENPP2MEN1KMT2APOLBCASP3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8383656-B2 | Thiazolidinedione energy restriction-mimetic agents | THE OHIO STATE UNIVERSITY RESEARCH FOUNDATION (US) | 2013-02-26 | — | — | US | disclosed |
| US-20110086895-A1 | THIAZOLIDINEDIONE ENERGY RESTRICTION-MIMETIC AGENTS | THE OHIO STATE UNIVERSITY RESEARCH FOUNDATION (US) | 2011-04-14 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20110086895-A1 | THIAZOLIDINEDIONE ENERGY RESTRICTION-MIMETIC AGENTS | PCK2, AK2, SIRT6 | ENPP2 1288/4885MEN1 4141/4885KMT2A 1663/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.