Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ACHE | P22303 | 2/20 | 0.39 |
| ▸ | AKR1C2 | P52895 | 1/20 | 0.36 |
| ▸ | AKR1C1 | Q04828 | 1/20 | 0.36 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.35 |
| ▸ | PTGS2 | P35354 | 4/20 | 0.34 |
| ▸ | MEN1 | O00255 | 2/20 | 0.34 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.34 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.34 |
| ▸ | MAPT | P10636 | 1/20 | 0.34 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.34 |
| ▸ | PTGS1 | P23219 | 2/20 | 0.33 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.33 |
| ▸ | TSHR | P16473 | 1/20 | 0.33 |
| ▸ | AR | P10275 | 1/20 | 0.33 |
| ▸ | NPC1 | O15118 | 2/20 | 0.33 |
| ▸ | RAB9A | P51151 | 2/20 | 0.33 |
| ▸ | HPRT1 | P00492 | 1/20 | 0.33 |
| ▸ | RCE1 | Q9Y256 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL19186972 | 0.93 | ACHE (0.43) | ACHEAKR1C2AKR1C1TDP1PTGS2 | |
| SCHEMBL17471814 | 0.84 | RAPGEF4 (0.38) | ACHETDP1MEN1ALDH1A1KMT2A | |
| SCHEMBL17070827 | 0.82 | RAPGEF4 (0.35) | ACHEPTGS2MEN1KMT2APTGS1 | |
| SCHEMBL16521126 | 0.82 | RAPGEF4 (0.35) | ACHEPTGS2MEN1KMT2APTGS1 | |
| SCHEMBL17471813 | 0.80 | MAPT (0.36) | ACHETDP1PTGS2MEN1ALDH1A1 | |
| SCHEMBL17471815 | 0.79 | PTGS2 (0.36) | AKR1C2PTGS2PTGS1 | |
| SCHEMBL17540392 | 0.78 | ALDH1A1 (0.47) | ACHETDP1ALDH1A1CYP3A4TSHR | |
| SCHEMBL14173108 | 0.77 | ACHE (0.54) | ACHEAKR1C2AKR1C1MEN1KMT2A | |
| SCHEMBL8192072 | 0.75 | ACHE (0.43) | ACHETDP1PTGS2MEN1ALDH1A1 | |
| SCHEMBL10014228 | 0.75 | ACHE (0.43) | ACHETDP1PTGS2MEN1ALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7923079-B2 | Liquid-crystalline medium and liquid-crystal display comprising 1,2-difluoroethene compounds | MERCK PATENT GMBH (DE) | 2011-04-12 | — | — | US | disclosed |
| US-7922934-B2 | s-Indacene and indeno[5,6-d][1,3]dioxol-derivatives and use thereof as components of liquid-crystal mixtures | MERCK PATENT GESELLSCHAFT MIT BESCHRANKTER HAFTUNG (DE) | 2011-04-12 | — | — | US | disclosed |
| US-20100155662-A1 | S-INDACENE AND INDENO[5,6-D][1,3]DIOXOL-DERIVATIVES AND USE THEREOF AS COMPONENTS OF LIQUID-CRYSTAL MIXTURES | MERCK PATENT GESELLSCHAFT (DE) | 2010-06-24 | — | — | US | disclosed |
| US-20100085529-A1 | LIQUID-CRYSTALLINE MEDIUM AND LIQUID-CRYSTAL DISPLAY COMPRISING 1,2-DIFLUOROETHENE COMPOUNDS | WITTEK MICHAEL | 2010-04-08 | — | — | US | disclosed |
| US-7651742-B2 | Liquid-crystalline medium and liquid-crystal display comprising 1,2-difluoroethene compounds | MERCK PATENT GMBH (DE) | 2010-01-26 | — | — | US | disclosed |
| US-20080260971-A1 | Liquid-Crystalline Medium and Liquid-Crystal Display Comprising 1,2-Difluoroethene Compounds | MERCK PATENT GMBH (DE) | 2008-10-23 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20100155662-A1 | S-INDACENE AND INDENO[5,6-D][1,3]DIOXOL-DERIVATIVES AND USE THEREOF AS COMPONENTS OF LIQUID-CRYSTAL MIXTURES | IPO5, SFXN3, SFXN1 | ACHE 2650/4885AKR1C2 3007/4885AKR1C1 2976/4885 |
| US-20080260971-A1 | Liquid-Crystalline Medium and Liquid-Crystal Display Comprising 1,2-Difluoroethene Compounds | CFL1, NEFM, CHRM1 | ACHE 2367/4885AKR1C2 3909/4885AKR1C1 3150/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.