Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 9/20 | 0.45 |
| ▸ | HSD17B10 | Q99714 | 4/20 | 0.45 |
| ▸ | TSHR | P16473 | 3/20 | 0.45 |
| ▸ | MAPK1 | P28482 | 3/20 | 0.45 |
| ▸ | TP53 | P04637 | 2/20 | 0.45 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.45 |
| ▸ | PSMB5 | P28074 | 1/20 | 0.44 |
| ▸ | ALOX15 | P16050 | 3/20 | 0.37 |
| ▸ | TERT | O14746 | 1/20 | 0.35 |
| ▸ | APP | P05067 | 1/20 | 0.35 |
| ▸ | KDM4E | B2RXH2 | 4/20 | 0.35 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.34 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.34 |
| ▸ | MAPT | P10636 | 5/20 | 0.34 |
| ▸ | HPGD | P15428 | 3/20 | 0.34 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.34 |
| ▸ | RAB9A | P51151 | 2/20 | 0.34 |
| ▸ | NPC1 | O15118 | 1/20 | 0.34 |
| ▸ | GAA | P10253 | 1/20 | 0.34 |
| ▸ | KCNH2 | Q12809 | 2/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8235134 | 0.83 | TERT (0.43) | ALDH1A1HSD17B10TSHRMAPK1HIF1A | |
| SCHEMBL145777 | 0.76 | ALDH1A1 (0.48) | ALDH1A1HSD17B10TSHRMAPK1TP53 | |
| SCHEMBL23671581 | 0.75 | ALDH1A1 (0.40) | ALDH1A1HSD17B10TSHRMAPK1TP53 | |
| SCHEMBL29914719 | 0.74 | KCNH2 (0.50) | ALDH1A1HSD17B10TSHRMAPK1TP53 | |
| SCHEMBL144585 | 0.74 | ALDH1A1 (0.47) | ALDH1A1HSD17B10TSHRMAPK1TP53 | |
| SCHEMBL90533 | 0.74 | KCNH2 (0.50) | ALDH1A1HSD17B10TSHRMAPK1TP53 | |
| SCHEMBL13958063 | 0.74 | MAPT (0.37) | ALDH1A1HSD17B10KDM4ECYP3A4MAPT | |
| SCHEMBL13366127 | 0.74 | PSMB5 (0.47) | ALDH1A1HSD17B10TSHRMAPK1TP53 | |
| Hydrochloric Acid SCHEMBL104308 | 0.73 | KCNH2 (0.51) | ALDH1A1HSD17B10TSHRMAPK1TP53 | |
| SCHEMBL3856198 | 0.73 | KCNH2 (0.49) | ALDH1A1HSD17B10TSHRMAPK1TP53 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 57 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-11116772-B2 | Medical methods utilising high purity diaminophenothiazinium compounds | WISTA LABORATORIES LTD. (SG) | 2021-09-14 | — | — | US | disclosed |
| US-11116772-B2 | Medical methods utilising high purity diaminophenothiazinium compounds | WISTA LABORATORIES LTD. (SG) | 2021-09-14 | — | — | US | disclosed |
| US-20200268767-A1 | MEDICAL METHODS UTILISING HIGH PURITY DIAMINOPHENOTHIAZINIUM COMPOUNDS | WISTA LABORATORIES LIMITED (SG) | 2020-08-27 | — | — | US | disclosed |
| US-20200268767-A1 | MEDICAL METHODS UTILISING HIGH PURITY DIAMINOPHENOTHIAZINIUM COMPOUNDS | WISTA LABORATORIES LIMITED (SG) | 2020-08-27 | — | — | US | disclosed |
| EP-3564223-A1 | METHODS OF CHEMICAL SYNTHESIS AND PURIFICATION OF DIAMINOPHENOTHIAZINIUM COMPOUNDS INCLUDING METHYLTHIONINIUM CHLORIDE (MTC) | WisTa Laboratories Ltd. (SG) | 2019-11-06 | — | — | EP | disclosed |
| EP-2322517-B1 | METHODS OF CHEMICAL SYNTHESIS AND PURIFICATION OF DIAMINOPHENOTHIAZINIUM COMPOUNDS INCLUDING METHYLTHIONINIUM CHLORIDE (MTC) | WISTA LAB LTD (SG) | 2019-04-24 | — | — | EP | disclosed |
| US-20180078562-A1 | MEDICAL METHODS UTILISING HIGH PURITY DIAMINOPHENOTHIAZINIUM COMPOUNDS | WISTA LABORATORIES LTD. (SG) | 2018-03-22 | — | — | US | disclosed |
| US-20180078562-A1 | MEDICAL METHODS UTILISING HIGH PURITY DIAMINOPHENOTHIAZINIUM COMPOUNDS | WISTA LABORATORIES LTD. (SG) | 2018-03-22 | — | — | US | disclosed |
| US-20180078562-A1 | MEDICAL METHODS UTILISING HIGH PURITY DIAMINOPHENOTHIAZINIUM COMPOUNDS | WISTA LABORATORIES LTD. (SG) | 2018-03-22 | — | — | US | disclosed |
| EP-2853293-B1 | Thioninium compounds and their use | WISTA LAB LTD (SG) | 2017-11-22 | — | — | EP | disclosed |
| US-20090209526-A1 | INHIBITORS OF PROTEIN AGGREGATION | WISTA LABORATORIES LTD | 2009-08-20 | — | — | US | disclosed |
| US-20080207603-A1 | Methods of Chemical Synthesis and Purification of Diaminophenothiazinium Compounds Including Methylthioninium Chloride (Mtc) | WISTA LABORATORIES LTD. | 2008-08-28 | — | — | US | disclosed |
| US-20080207603-A1 | Methods of Chemical Synthesis and Purification of Diaminophenothiazinium Compounds Including Methylthioninium Chloride (Mtc) | WISTA LABORATORIES LTD. | 2008-08-28 | — | — | US | disclosed |
| US-20080207603-A1 | Methods of Chemical Synthesis and Purification of Diaminophenothiazinium Compounds Including Methylthioninium Chloride (Mtc) | WISTA LABORATORIES LTD. | 2008-08-28 | — | — | US | disclosed |
| WO-2007110629-A1 | INHIBITORS OF PROTEIN AGGREGATION | WISTA LABORATORIES LTD (SG) | 2007-10-04 | — | — | WO | disclosed |
| WO-2007110630-A1 | THIONINIUM COMPOUNDS AND THEIR USE | WISTA LABORATORIES LTD. (SG) | 2007-10-04 | — | — | WO | disclosed |
| EP-1799662-A2 | METHODS OF CHEMICAL SYNTHESIS AND PURIFICATION OF DIAMINOPHENOTHIAZINIUM COMPOUNDS INCLUDING METHYLTHIONINIUM CHLORIDE (MTC) | Wista Laboratories Ltd. (SG) | 2007-06-27 | — | — | EP | disclosed |
| US-20060287523-A1 | Methods of chemical synthesis and purification of diaminophenothiazinium compounds including methylthioninium chloride (MTC) | WISTA LABORATORIES LTD. (SG) | 2006-12-21 | — | — | US | disclosed |
| WO-2006032879-A2 | METHODS OF CHEMICAL SYNTHESIS AND PURIFICATION OF DIAMINOPHENOTHIAZINIUM COMPOUNDS INCLUDING METHYLTHIONINIUM CHLORIDE (MTC) | WISTA LABORATORIES LTD. (SG) | 2006-03-30 | — | — | WO | disclosed |
| WO-2006032879-A2 | METHODS OF CHEMICAL SYNTHESIS AND PURIFICATION OF DIAMINOPHENOTHIAZINIUM COMPOUNDS INCLUDING METHYLTHIONINIUM CHLORIDE (MTC) | WISTA LABORATORIES LTD. (SG) | 2006-03-30 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (6 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-11116772-B2 | Medical methods utilising high purity diaminophenothiazinium compounds | MGMT, MAPT, TST | ALDH1A1 3409/4885HSD17B10 4790/4885TSHR 1274/4885 |
| US-20090209526-A1 | INHIBITORS OF PROTEIN AGGREGATION | SNCA, PARK7, HTT | ALDH1A1 3469/4885HSD17B10 4411/4885TSHR 3677/4885 |
| US-20080207603-A1 | Methods of Chemical Synthesis and Purification of Diaminophenothiazinium Compounds Including Methylthioninium Chloride (Mtc) | MGMT, MAPT, CRBN | ALDH1A1 3952/4885HSD17B10 4612/4885TSHR 841/4885 |
| US-20060287523-A1 | Methods of chemical synthesis and purification of diaminophenothiazinium compounds including methylthioninium chloride (MTC) | MGMT, MAPT, TST | ALDH1A1 3877/4885HSD17B10 4612/4885TSHR 1397/4885 |
| US-20180078562-A1 | MEDICAL METHODS UTILISING HIGH PURITY DIAMINOPHENOTHIAZINIUM COMPOUNDS | MGMT, MAPT, TST | ALDH1A1 3735/4885HSD17B10 4780/4885TSHR 1506/4885 |
| US-20200268767-A1 | MEDICAL METHODS UTILISING HIGH PURITY DIAMINOPHENOTHIAZINIUM COMPOUNDS | MGMT, MAPT, TST | ALDH1A1 3735/4885HSD17B10 4780/4885TSHR 1506/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.