Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPK1 | P28482 | 3/20 | 0.48 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.48 |
| ▸ | HPGD | P15428 | 2/20 | 0.48 |
| ▸ | LMNA | P02545 | 2/20 | 0.48 |
| ▸ | MAPT | P10636 | 2/20 | 0.48 |
| ▸ | RAF1 | P04049 | 1/20 | 0.48 |
| ▸ | GFER | P55789 | 1/20 | 0.48 |
| ▸ | PAX8 | Q06710 | 1/20 | 0.48 |
| ▸ | VCAM1 | P19320 | 10/20 | 0.47 |
| ▸ | APLNR | P35414 | 1/20 | 0.45 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.42 |
| ▸ | TXNRD1 | Q16881 | 2/20 | 0.42 |
| ▸ | TSHR | P16473 | 2/20 | 0.42 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.42 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.42 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.42 |
| ▸ | TXNRD3 | Q86VQ6 | 1/20 | 0.42 |
| ▸ | TXNRD2 | Q9NNW7 | 1/20 | 0.42 |
| ▸ | MEN1 | O00255 | 2/20 | 0.41 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL31191383 | 1.00 | MAPK1 (0.48) | MAPK1ALDH1A1HPGDLMNAMAPT | |
| SCHEMBL31009400 | 0.91 | APLNR (0.45) | MAPK1ALDH1A1HPGDLMNAMAPT | |
| SCHEMBL29624965 | 0.87 | TSHR (0.53) | MAPK1ALDH1A1HPGDLMNAMAPT | |
| SCHEMBL998214 | 0.87 | TSHR (0.53) | MAPK1ALDH1A1HPGDLMNAMAPT | |
| SCHEMBL11442494 | 0.86 | LMNA (0.45) | MAPK1ALDH1A1HPGDLMNAMAPT | |
| SCHEMBL23388212 | 0.83 | MAPT (0.70) | MAPK1ALDH1A1HPGDLMNAMAPT | |
| SCHEMBL29936440 | 0.82 | APLNR (0.43) | MAPK1ALDH1A1HPGDLMNAMAPT | |
| SCHEMBL23388231 | 0.82 | APLNR (0.43) | MAPK1ALDH1A1HPGDLMNAMAPT | |
| SCHEMBL31237064 | 0.81 | ALDH1A1 (0.53) | ALDH1A1LMNAMAPTVCAM1TDP1 | |
| SCHEMBL1275648 | 0.81 | ALDH1A1 (0.53) | ALDH1A1LMNAMAPTVCAM1TDP1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 71 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-112159329-B | Co-production preparation method of o-amino trifluoromethoxybenzene and m-amino trifluoromethoxybenzene | 大连奇凯医药科技有限公司 | 2022-09-06 | — | — | CN | claimed |
| CN-112159329-A | Co-production preparation method of o-amino trifluoromethoxybenzene and m-amino trifluoromethoxybenzene | 大连奇凯医药科技有限公司 | 2021-01-01 | — | — | CN | claimed |
| US-11655203-B2 | Nitration | ETH ZURICH (CH) | 2023-05-23 | — | — | US | disclosed |
| US-11655203-B2 | Nitration | ETH ZURICH (CH) | 2023-05-23 | — | — | US | disclosed |
| US-11655203-B2 | Nitration | ETH ZURICH (CH) | 2023-05-23 | — | — | US | disclosed |
| CN-112159329-B | Co-production preparation method of o-amino trifluoromethoxybenzene and m-amino trifluoromethoxybenzene | 大连奇凯医药科技有限公司 | 2022-09-06 | — | — | CN | disclosed |
| CN-112159329-B | Co-production preparation method of o-amino trifluoromethoxybenzene and m-amino trifluoromethoxybenzene | 大连奇凯医药科技有限公司 | 2022-09-06 | — | — | CN | disclosed |
| US-20220009875-A1 | NITRATION | ETH ZURICH (CH) | 2022-01-13 | — | — | US | disclosed |
| US-20220009875-A1 | NITRATION | ETH ZURICH (CH) | 2022-01-13 | — | — | US | disclosed |
| CN-113302186-A | Nitration | 瑞士苏黎世联邦理工学院 | 2021-08-24 | — | — | CN | disclosed |
| EP-3717464-B1 | NITRATION | ETH ZUERICH (CH) | 2021-06-16 | — | — | EP | disclosed |
| WO-2001077062-A1 | METHOD FOR PRODUCING 4-BROMO- AND 4-CHLORO-2-NITRO-1-TRIFLUOROMETHOXYBENZENE | BAYER AKTIENGESELLSCHAFT (DE) | 2001-10-18 | — | — | WO | disclosed |
| EP-0820981-B1 | Process for the preparation of 2-trifluoromethoxy-aniline | BAYER AG (DE) | 2000-10-18 | — | — | EP | disclosed |
| US-6121492-A | Method for preparing 2-trifluoro-methoxy-aniline | RHODIA CHIMIE (FR) | 2000-09-19 | — | — | US | disclosed |
| EP-0984920-A1 | NOVEL METHOD FOR PREPARING 2-TRIFLUORO-METHOXY-ANILINE | RHODIA CHIMIE (FR) | 2000-03-15 | — | — | EP | disclosed |
| WO-1998054121-A1 | NOVEL METHOD FOR PREPARING 2-TRIFLUORO-METHOXY-ANILINE | RHODIA-CHIMIE (FR) | 1998-12-03 | — | — | WO | disclosed |
| US-5840983-A | Process for preparing 2-trifluoromethoxy-aniline | BAYER AKTIENGESELLSCHAFT (DE) | 1998-11-24 | — | — | US | disclosed |
| EP-0820981-A1 | Process for the preparation of 2-trifluoromethoxy-aniline | BAYER AG (DE) | 1998-01-28 | — | — | EP | disclosed |
| US-4259532-A | TRIFLUOROMETHOXYHALOPHENOL | E. I. DU PONT DE NEMOURS AND COMPANY (US) | 1981-03-31 | — | — | US | disclosed |
| US-4192669-A | DERIVATIVES OF 2-(4-(4-(TRIFLUOROMETHOXY)-PHENOXY)PHENOXY)AALKANOIC ACIDS | E. I. DU PONT DE NEMOURS AND COMPANY (US) | 1980-03-11 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20220009875-A1 | NITRATION | NOS1, NOS2, NOS3 | MAPK1 430/4885ALDH1A1 2335/4885HPGD 464/4885 |
| US-11655203-B2 | Nitration | NOS1, NOS2, NOS3 | MAPK1 430/4885ALDH1A1 2335/4885HPGD 464/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.