Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.45 |
| ▸ | TSHR | P16473 | 3/20 | 0.45 |
| ▸ | HSD17B10 | Q99714 | 3/20 | 0.45 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.45 |
| ▸ | RECQL | P46063 | 2/20 | 0.45 |
| ▸ | MEN1 | O00255 | 2/20 | 0.37 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.37 |
| ▸ | MAPT | P10636 | 2/20 | 0.37 |
| ▸ | HPGD | P15428 | 2/20 | 0.37 |
| ▸ | TTR | P02766 | 2/20 | 0.37 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.37 |
| ▸ | SLC22A2 | O15244 | 1/20 | 0.37 |
| ▸ | SLC22A1 | O15245 | 1/20 | 0.37 |
| ▸ | NR1I2 | O75469 | 1/20 | 0.37 |
| ▸ | SLC22A3 | O75751 | 1/20 | 0.37 |
| ▸ | EGFR | P00533 | 1/20 | 0.37 |
| ▸ | LMNA | P02545 | 1/20 | 0.37 |
| ▸ | ESR1 | P03372 | 1/20 | 0.37 |
| ▸ | ERBB2 | P04626 | 1/20 | 0.37 |
| ▸ | LCK | P06239 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Bithionoloxide SCHEMBL69373 | 0.89 | HSD17B10 (0.56) | ALDH1A1TSHRHSD17B10CYP3A4RECQL | |
| SCHEMBL30804415 | 0.78 | ALDH1A1 (0.65) | ALDH1A1TSHRHSD17B10CYP3A4RECQL | |
| SCHEMBL1893469 | 0.78 | ALDH1A1 (0.65) | ALDH1A1TSHRHSD17B10CYP3A4RECQL | |
| Bithionoloxide SCHEMBL11549920 | 0.73 | TSHR (0.40) | ALDH1A1TSHRHSD17B10CYP3A4RECQL | |
| SCHEMBL3337579 | 0.72 | TSHR (0.39) | ALDH1A1TSHRHSD17B10CYP3A4RECQL | |
| SCHEMBL29904878 | 0.72 | TSHR (0.39) | ALDH1A1TSHRHSD17B10CYP3A4RECQL | |
| SCHEMBL1182540 | 0.71 | CA1 (0.58) | ALDH1A1TSHRHSD17B10CYP3A4RECQL | |
| SCHEMBL5372785 | 0.70 | HSD17B10 (0.40) | ALDH1A1TSHRHSD17B10CYP3A4RECQL | |
| SCHEMBL29904874 | 0.70 | HSD17B10 (0.40) | ALDH1A1TSHRHSD17B10CYP3A4RECQL | |
| SCHEMBL14644985 | 0.67 | HSD17B10 (0.77) | ALDH1A1TSHRHSD17B10CYP3A4RECQL |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20170281649-A1 | COMPOUNDS AND THERAPEUTIC USES | UNITY BIOTECHNOLOGY, INC. | 2017-10-05 | — | — | US | disclosed |
| WO-2011041731-A2 | METHOD OF INHIBITING BCL-2-RELATED SURVIVAL PROTEINS | FRED HUTCHINSON CANCER RESEARCH CENTER (US) | 2011-04-07 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20170281649-A1 | COMPOUNDS AND THERAPEUTIC USES | TP53, NQO1, SHMT2 | ALDH1A1 545/4885TSHR 3771/4885HSD17B10 2430/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.