Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CTSD | P07339 | 2/20 | 0.45 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.43 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.43 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.42 |
| ▸ | HRH3 | Q9Y5N1 | 1/20 | 0.42 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.40 |
| ▸ | LMNA | P02545 | 2/20 | 0.40 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.40 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.40 |
| ▸ | CYP2C9 | P11712 | 2/20 | 0.40 |
| ▸ | CYP2C19 | P33261 | 2/20 | 0.40 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.40 |
| ▸ | HTT | P42858 | 1/20 | 0.40 |
| ▸ | NLRP3 | Q96P20 | 1/20 | 0.40 |
| ▸ | MAT2A | P31153 | 1/20 | 0.39 |
| ▸ | F7 | P08709 | 1/20 | 0.39 |
| ▸ | F3 | P13726 | 1/20 | 0.39 |
| ▸ | C1R | P00736 | 2/20 | 0.38 |
| ▸ | KRAS | P01116 | 2/20 | 0.38 |
| ▸ | SOS1 | Q07889 | 2/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL12788663 | 0.83 | ALDH1A1 (0.48) | ALDH1A1L3MBTL1KDM4ELMNACYP1A2 | |
| SCHEMBL12789552 | 0.82 | KDM4E (0.46) | ALDH1A1L3MBTL1KDM4ELMNACYP1A2 | |
| SCHEMBL12788672 | 0.81 | TACR1 (0.37) | ALDH1A1L3MBTL1KDM4ECYP1A2CYP2C9 | |
| SCHEMBL12788398 | 0.81 | LMNA (0.45) | ALDH1A1L3MBTL1KDM4ELMNACYP1A2 | |
| SCHEMBL12788750 | 0.81 | CTSD (0.41) | CTSDALDH1A1L3MBTL1KDM4ELMNA | |
| SCHEMBL12846928 | 0.81 | KDM4E (0.41) | ALDH1A1L3MBTL1KDM4ELMNACYP1A2 | |
| SCHEMBL12788449 | 0.80 | MAOB (0.44) | KDM4E | |
| SCHEMBL13250425 | 0.80 | PDE2A (0.41) | ALDH1A1L3MBTL1KRASSOS1MEN1 | |
| SCHEMBL12788721 | 0.80 | KDM4C (0.41) | ALDH1A1KDM4ELMNACYP1A2CYP2C9 | |
| SCHEMBL12788591 | 0.79 | PTGFR (0.41) | ALDH1A1L3MBTL1KDM4EGLAMEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2297117-B1 | BICYCLIC HETEROCYCLE DERIVATIVES AND USE THEREOF AS GPR119 MODULATORS | MERCK SHARP & DOHME (US) | 2012-10-31 | — | — | EP | disclosed |
| US-20110065671-A1 | BICYCLIC HETEROCYCLE DERIVATIVES AND USE THEREOF AS GPR119 MODULATORS | MERCK SHARP & DOHME CORP. | 2011-03-17 | — | — | US | disclosed |
| US-20110065671-A1 | BICYCLIC HETEROCYCLE DERIVATIVES AND USE THEREOF AS GPR119 MODULATORS | MERCK SHARP & DOHME CORP. | 2011-03-17 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20110065671-A1 | BICYCLIC HETEROCYCLE DERIVATIVES AND USE THEREOF AS GPR119 MODULATORS | GPR119, GPR39, GPR65 | CTSD 2844/4885ALDH1A1 833/4885L3MBTL1 4270/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.