SCHEMBL12799862

SCHEMBL12799862

Cc1cccc(-c2cc(-c3ccc4oc5ccc(C)cc5c4c3)c3oc4ccccc4c3c2)c1

nearest known ligand 0.44

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
▸ MAPT P10636 5/20 0.44
▸ ALDH1A1 P00352 4/20 0.44
▸ KDM4E B2RXH2 4/20 0.44
▸ HPGD P15428 3/20 0.44
▸ TP53 P04637 2/20 0.44
▸ CYP3A4 P08684 2/20 0.44
▸ HSD17B10 Q99714 2/20 0.44
▸ ALOX5 P09917 2/20 0.44
▸ MAPK1 P28482 1/20 0.44
▸ TDP1 Q9NUW8 1/20 0.44
▸ MAOB P27338 3/20 0.41
▸ L3MBTL1 Q9Y468 2/20 0.40
▸ MEN1 O00255 2/20 0.37
▸ KMT2A Q03164 2/20 0.37
▸ ATM Q13315 1/20 0.37
▸ RCE1 Q9Y256 1/20 0.37
▸ TNKS O95271 1/20 0.37
▸ PARP1 P09874 1/20 0.37
▸ TNKS2 Q9H2K2 1/20 0.37
▸ PARP2 Q9UGN5 1/20 0.37

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL12799828 1.00 MAPT (0.44) MAPTALDH1A1KDM4EHPGDTP53
SCHEMBL12969344 0.97 ALOX5 (0.46) MAPTALDH1A1KDM4EHPGDTP53
SCHEMBL12968447 0.97 ALOX5 (0.46) MAPTALDH1A1KDM4EHPGDTP53
SCHEMBL12968523 0.92 KDM4E (0.44) MAPTALDH1A1KDM4EHPGDTP53
SCHEMBL12968441 0.92 KDM4E (0.44) MAPTALDH1A1KDM4EHPGDTP53
SCHEMBL12799824 0.92 ALOX5 (0.47) MAPTALDH1A1KDM4EHPGDTP53
SCHEMBL17625273 0.90 MAPT (0.42) MAPTALDH1A1KDM4EHPGDTP53
SCHEMBL12799821 0.88 ALOX5 (0.46) MAPTALDH1A1KDM4EHPGDTP53
SCHEMBL12968451 0.88 MEN1 (0.43) MAPTALDH1A1KDM4EHPGDTP53
SCHEMBL12968431 0.88 ALOX5 (0.46) MAPTALDH1A1KDM4EHPGDTP53

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 11 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-10431750-B2 4H-imidazo[1,2-a]imidazoles for electronic applications UDC IRELAND LIMITED (IE) 2019-10-01 — — US disclosed
US-20190273211-A1 4H-Imidazo[1,2-a]imidazoles for Electronic Applications UDC IRELAND LTD (IE) 2019-09-05 — — US disclosed
US-9806270-B2 4H-imidazo[1,2-a]imidazoles for electronic applications UDC IRELAND LIMITED (IE) 2017-10-31 — — US disclosed
US-9806270-B2 4H-imidazo[1,2-a]imidazoles for electronic applications UDC IRELAND LIMITED (IE) 2017-10-31 — — US disclosed
US-20160190480-A1 4H-Imidazo[1,2-a]imidazoles for Electronic Applications BASF SE (DE) 2016-06-30 — — US disclosed
US-20160190480-A1 4H-Imidazo[1,2-a]imidazoles for Electronic Applications BASF SE (DE) 2016-06-30 — — US disclosed
EP-3034508-A1 4H-IMIDAZO[1,2-A]IMIDAZOLES FOR ELECTRONIC APPLICATIONS BASF SE (DE) 2016-06-22 — — EP disclosed
EP-2688889-B1 4H-IMIDAZO[1,2-A]IMIDAZOLES FOR ELECTRONIC APPLICATIONS BASF SE (DE) 2016-05-18 — — EP disclosed
WO-2012130709-A1 4H-IMIDAZO[1,2-A]IMIDAZOLES FOR ELECTRONIC APPLICATIONS BASF SE (DE) 2012-10-04 — — WO disclosed
US-20120241681-A1 4H-Imidazo[1,2-a]imidazoles for Electronic Applications BASF SE (DE) 2012-09-27 — — US disclosed
US-20120241681-A1 4H-Imidazo[1,2-a]imidazoles for Electronic Applications BASF SE (DE) 2012-09-27 — — US disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (4 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20120241681-A1 4H-Imidazo[1,2-a]imidazoles for Electronic Applications EIF4A1, ITPR2, ITPR1 MAPT 1159/4885ALDH1A1 355/4885KDM4E 1166/4885
US-10431750-B2 4H-imidazo[1,2-a]imidazoles for electronic applications EIF4A1, ITPR2, ITPR1 MAPT 1159/4885ALDH1A1 355/4885KDM4E 1166/4885
US-20190273211-A1 4H-Imidazo[1,2-a]imidazoles for Electronic Applications PAH, NISCH, KCNH1 MAPT 1665/4885ALDH1A1 405/4885KDM4E 1128/4885
US-20160190480-A1 4H-Imidazo[1,2-a]imidazoles for Electronic Applications PAH, NISCH, KCNH1 MAPT 1665/4885ALDH1A1 405/4885KDM4E 1128/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.

Send feedback