SCHEMBL12801006

SCHEMBL12801006

c1cc(-n2c3ccccc3n3c4ccccc4nc23)cc(-n2c3ccccc3n3c4ccccc4nc23)c1

nearest known ligand 0.42

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
MAPK1 P28482 2/20 0.42
HTT P42858 1/20 0.42
ADORA1 P30542 4/20 0.38
ADORA2B P29275 1/20 0.38
KDM4E B2RXH2 6/20 0.37
ALDH1A1 P00352 4/20 0.37
MEN1 O00255 3/20 0.37
KMT2A Q03164 3/20 0.37
HPGD P15428 3/20 0.37
MAPT P10636 2/20 0.37
SMN1; SMN2 Q16637 2/20 0.37
TSHR P16473 2/20 0.37
ADORA3 P0DMS8 3/20 0.36
ADORA2A P29274 3/20 0.36
NR1H2 P55055 1/20 0.36
NR1H3 Q13133 1/20 0.36
HSD17B10 Q99714 2/20 0.36
CSNK1A1 P48729 1/20 0.36
CLK2 P49760 1/20 0.36
LIMK1 P53667 1/20 0.36

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL18083391 0.98 MAPK1 (0.41) MAPK1HTTADORA1ADORA2BKDM4E
SCHEMBL18083349 0.95 MAPK1 (0.43) MAPK1HTTADORA1KDM4EALDH1A1
SCHEMBL21347068 0.92 KDM4E (0.44) MAPK1HTTADORA1ADORA2BKDM4E
SCHEMBL12801009 0.92 ADORA1 (0.41) MAPK1HTTADORA1ADORA2BKDM4E
SCHEMBL14868035 0.89 MAPK1 (0.53) MAPK1HTTADORA1ADORA2BKDM4E
SCHEMBL30271371 0.89 MAPK1 (0.41) MAPK1HTTADORA1MEN1KMT2A
SCHEMBL12800987 0.89 MAPK1 (0.41) MAPK1HTTADORA1MEN1KMT2A
SCHEMBL25606967 0.89 MAPK1 (0.37) MAPK1HTTADORA1ADORA2BKDM4E
SCHEMBL17142364 0.89 ADORA3 (0.39) MAPK1HTTADORA1ADORA2BKDM4E
SCHEMBL15631653 0.89 ADORA2B (0.43) MAPK1HTTADORA1ADORA2BKDM4E

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 16 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-20240025927-A1 ORGANIC ELECTROLUMINESCENT MATERIALS AND DEVICES UNIVERSAL DISPLAY CORPORATION (US) 2024-01-25 US disclosed
US-20230363254-A1 ORGANIC ELECTROLUMINESCENT MATERIALS AND DEVICES UNIVERSAL DISPLAY CORPORATION (US) 2023-11-09 US disclosed
US-20230329089-A1 ORGANIC ELECTROLUMINESCENT MATERIALS AND DEVICES UNIVERSAL DISPLAY CORPORATION (US) 2023-10-12 US disclosed
US-20230329089-A1 ORGANIC ELECTROLUMINESCENT MATERIALS AND DEVICES UNIVERSAL DISPLAY CORPORATION (US) 2023-10-12 US disclosed
US-11716899-B2 Organic electroluminescent materials and devices UNIVERSAL DISPLAY CORPORATION (US) 2023-08-01 US disclosed
US-10431750-B2 4H-imidazo[1,2-a]imidazoles for electronic applications UDC IRELAND LIMITED (IE) 2019-10-01 US disclosed
US-20190273211-A1 4H-Imidazo[1,2-a]imidazoles for Electronic Applications UDC IRELAND LTD (IE) 2019-09-05 US disclosed
US-9806270-B2 4H-imidazo[1,2-a]imidazoles for electronic applications UDC IRELAND LIMITED (IE) 2017-10-31 US disclosed
US-9806270-B2 4H-imidazo[1,2-a]imidazoles for electronic applications UDC IRELAND LIMITED (IE) 2017-10-31 US disclosed
US-20160190480-A1 4H-Imidazo[1,2-a]imidazoles for Electronic Applications BASF SE (DE) 2016-06-30 US disclosed
US-20160190480-A1 4H-Imidazo[1,2-a]imidazoles for Electronic Applications BASF SE (DE) 2016-06-30 US disclosed
EP-3034508-A1 4H-IMIDAZO[1,2-A]IMIDAZOLES FOR ELECTRONIC APPLICATIONS BASF SE (DE) 2016-06-22 EP disclosed
EP-2688889-B1 4H-IMIDAZO[1,2-A]IMIDAZOLES FOR ELECTRONIC APPLICATIONS BASF SE (DE) 2016-05-18 EP disclosed
WO-2012130709-A1 4H-IMIDAZO[1,2-A]IMIDAZOLES FOR ELECTRONIC APPLICATIONS BASF SE (DE) 2012-10-04 WO disclosed
US-20120241681-A1 4H-Imidazo[1,2-a]imidazoles for Electronic Applications BASF SE (DE) 2012-09-27 US disclosed
US-20120241681-A1 4H-Imidazo[1,2-a]imidazoles for Electronic Applications BASF SE (DE) 2012-09-27 US disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (6 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20120241681-A1 4H-Imidazo[1,2-a]imidazoles for Electronic Applications EIF4A1, ITPR2, ITPR1 MAPK1 1181/4885HTT 2893/4885ADORA1 2120/4885
US-10431750-B2 4H-imidazo[1,2-a]imidazoles for electronic applications EIF4A1, ITPR2, ITPR1 MAPK1 1181/4885HTT 2893/4885ADORA1 2120/4885
US-20190273211-A1 4H-Imidazo[1,2-a]imidazoles for Electronic Applications PAH, NISCH, KCNH1 MAPK1 1674/4885HTT 298/4885ADORA1 3066/4885
US-20230329089-A1 ORGANIC ELECTROLUMINESCENT MATERIALS AND DEVICES NR1H2, OXER1, NR1H3 MAPK1 830/4885HTT 3729/4885ADORA1 1766/4885
US-20240025927-A1 ORGANIC ELECTROLUMINESCENT MATERIALS AND DEVICES OCIAD1, OCIAD2, ODC1 MAPK1 2196/4885HTT 2210/4885ADORA1 4460/4885
US-20160190480-A1 4H-Imidazo[1,2-a]imidazoles for Electronic Applications PAH, NISCH, KCNH1 MAPK1 1674/4885HTT 298/4885ADORA1 3066/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.