Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PCNA | P12004 | 14/20 | 0.68 |
| ▸ | LIG1 | P18858 | 1/20 | 0.67 |
| ▸ | THRB | P10828 | 5/20 | 0.52 |
| ▸ | THRA | P10827 | 3/20 | 0.52 |
| ▸ | LMNA | P02545 | 3/20 | 0.52 |
| ▸ | MEN1 | O00255 | 2/20 | 0.52 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.52 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.52 |
| ▸ | TSHR | P16473 | 1/20 | 0.52 |
| ▸ | GABRP | O00591 | 1/20 | 0.52 |
| ▸ | GABRD | O14764 | 1/20 | 0.52 |
| ▸ | ABCB11 | O95342 | 1/20 | 0.52 |
| ▸ | F2 | P00734 | 1/20 | 0.52 |
| ▸ | GABRA1 | P14867 | 1/20 | 0.52 |
| ▸ | GABRB1 | P18505 | 1/20 | 0.52 |
| ▸ | GABRG2 | P18507 | 1/20 | 0.52 |
| ▸ | GABRB3 | P28472 | 1/20 | 0.52 |
| ▸ | ADORA1 | P30542 | 1/20 | 0.52 |
| ▸ | GABRA5 | P31644 | 1/20 | 0.52 |
| ▸ | GABRA3 | P34903 | 1/20 | 0.52 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL12808488 | 0.87 | THRB (0.70) | PCNALIG1THRBTHRALMNA | |
| SCHEMBL8187037 | 0.85 | THRB (0.67) | PCNALIG1THRBTHRALMNA | |
| SCHEMBL8448639 | 0.84 | TAAR5 (0.60) | PCNALIG1MEN1KMT2APPARG | |
| SCHEMBL4449390 | 0.83 | PCNA (0.74) | PCNALIG1THRBTHRALMNA | |
| SCHEMBL25773001 | 0.82 | PCNA (0.72) | PCNALIG1THRBTHRALMNA | |
| SCHEMBL20385981 | 0.82 | THRB (0.49) | PCNALIG1THRBTHRALMNA | |
| SCHEMBL428139 | 0.81 | PCNA (1.00) | PCNALIG1THRBTHRALMNA | |
| SCHEMBL1487713 | 0.81 | PCNA (1.00) | PCNALIG1THRBTHRALMNA | |
| SCHEMBL445767 | 0.81 | PCNA (1.00) | PCNALIG1THRBTHRALMNA | |
| SCHEMBL16124416 | 0.81 | PCNA (0.80) | PCNALIG1THRBTHRALMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20110064773-A1 | PHARMACEUTICAL COMPOSITIONS COMPRISING A THYROID HORMON AND THEIR THERAPEUTIC USE | UNIVERSITE JOSEPH FOURIER (FR) | 2011-03-17 | — | — | US | disclosed |
| WO-2008138995-A1 | NEW PHARMACEUTICAL COMPOSITIONS COMPRISING A THYROID HORMON AND THEIR THERAPEUTIC USE | UNIVERSITE JOSEPH FOURIER (FR) | 2008-11-20 | — | — | WO | disclosed |
| WO-2008138993-A1 | NEW PHARMACEUTICAL COMPOSITIONS COMPRISING DIIODOTHYRONINE AND THEIR THERAPEUTIC USE | UNIVERSITE JOSEPH FOURIER (FR) | 2008-11-20 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20110064773-A1 | PHARMACEUTICAL COMPOSITIONS COMPRISING A THYROID HORMON AND THEIR THERAPEUTIC USE | TPO, TSHR, THRA | PCNA 4833/4885LIG1 4885/4885THRB 5/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.