Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | DNMT1 | P26358 | 2/20 | 0.57 |
| ▸ | LMNA | P02545 | 2/20 | 0.57 |
| ▸ | MTOR | P42345 | 2/20 | 0.57 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.57 |
| ▸ | TP53 | P04637 | 2/20 | 0.57 |
| ▸ | HTT | P42858 | 2/20 | 0.57 |
| ▸ | BLM | P54132 | 2/20 | 0.57 |
| ▸ | GMNN | O75496 | 1/20 | 0.57 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.57 |
| ▸ | THPO | P40225 | 1/20 | 0.57 |
| ▸ | RAB9A | P51151 | 1/20 | 0.57 |
| ▸ | HBB | P68871 | 1/20 | 0.57 |
| ▸ | PMP22 | Q01453 | 1/20 | 0.57 |
| ▸ | ADRB1 | P08588 | 1/20 | 0.39 |
| ▸ | HINT1 | P49773 | 2/20 | 0.36 |
| ▸ | THRB | P10828 | 1/20 | 0.36 |
| ▸ | MDM2 | Q00987 | 1/20 | 0.36 |
| ▸ | NCOA1 | Q15788 | 1/20 | 0.36 |
| ▸ | NCOA3 | Q9Y6Q9 | 1/20 | 0.36 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL381847 | 0.83 | LMNA (0.57) | LMNAMTORTHRBMDM2NCOA1 | |
| SCHEMBL1120568 | 0.79 | HINT1 (0.59) | HINT1 | |
| SCHEMBL25917145 | 0.79 | DNMT1 (0.63) | DNMT1LMNAMTORALDH1A1TP53 | |
| SCHEMBL313550 | 0.78 | AHCY (0.60) | LMNABLMTHRBSMN1; SMN2TSHR | |
| SCHEMBL12415519 | 0.78 | LMNA (0.69) | DNMT1LMNAMTORALDH1A1TP53 | |
| SCHEMBL15689915 | 0.78 | LMNA (0.69) | DNMT1LMNAMTORALDH1A1TP53 | |
| SCHEMBL31206056 | 0.77 | DNMT1 (0.61) | DNMT1LMNAMTORALDH1A1TP53 | |
| Azacitidine SCHEMBL16498253 | 0.76 | LMNA (0.90) | DNMT1LMNAMTORALDH1A1TP53 | |
| Azacitidine SCHEMBL27819363 | 0.75 | LMNA (0.88) | DNMT1LMNAMTORALDH1A1TP53 | |
| SCHEMBL720980 | 0.74 | AHCY (0.46) | LMNABLMTHRBTSHRADORA3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-9951098-B2 | Synthesis of 5-azacytidine | PHARMION LLC (US) | 2018-04-24 | — | — | US | disclosed |
| EP-2691408-B1 | SYNTHESIS OF 5-AZACYTIDINE | CELGENE INT SÁRL (CH) | 2017-06-28 | — | — | EP | disclosed |
| US-20140128593-A1 | SYNTHESIS OF 5-AZACYTIDINE | CELGENE INTERNATIONAL SARL (US) | 2014-05-08 | — | — | US | disclosed |
| CN-103619864-A | Systhesis of 5-azacytidine | CELGENE INTERNAT SARL | 2014-03-05 | — | — | CN | disclosed |
| EP-2691408-A1 | SYSTHESIS OF 5-AZACYTIDINE | Celgene International SÁRL (CH) | 2014-02-05 | — | — | EP | disclosed |
| WO-2012135405-A1 | SYSTHESIS OF 5-AZACYTIDINE | PHARMION LLC (US) | 2012-10-04 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20140128593-A1 | SYNTHESIS OF 5-AZACYTIDINE | AZI2, TET2, DNMT1 | DNMT1 3/4885LMNA 1783/4885MTOR 1051/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.