Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | RAB9A | P51151 | 8/20 | 0.55 |
| ▸ | NPC1 | O15118 | 5/20 | 0.55 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.55 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.55 |
| ▸ | ALDH1A1 | P00352 | 6/20 | 0.47 |
| ▸ | ALOX12 | P18054 | 1/20 | 0.47 |
| ▸ | MAPT | P10636 | 3/20 | 0.43 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.43 |
| ▸ | LMNA | P02545 | 2/20 | 0.43 |
| ▸ | POLB | P06746 | 2/20 | 0.43 |
| ▸ | HPGD | P15428 | 2/20 | 0.43 |
| ▸ | MEN1 | O00255 | 1/20 | 0.43 |
| ▸ | USP2 | O75604 | 1/20 | 0.43 |
| ▸ | THRB | P10828 | 1/20 | 0.43 |
| ▸ | PTPN7 | P35236 | 1/20 | 0.43 |
| ▸ | RECQL | P46063 | 1/20 | 0.43 |
| ▸ | BLM | P54132 | 1/20 | 0.43 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.43 |
| ▸ | MCL1 | Q07820 | 1/20 | 0.43 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL12828599 | 0.91 | RAB9A (0.45) | RAB9ANPC1SMN1; SMN2L3MBTL1ALDH1A1 | |
| SCHEMBL12828993 | 0.91 | RAB9A (0.44) | RAB9ANPC1SMN1; SMN2L3MBTL1ALDH1A1 | |
| SCHEMBL12828997 | 0.90 | MAPT (0.49) | RAB9ANPC1SMN1; SMN2L3MBTL1ALDH1A1 | |
| SCHEMBL12828600 | 0.90 | RAB9A (0.43) | RAB9ANPC1SMN1; SMN2L3MBTL1ALDH1A1 | |
| SCHEMBL12828532 | 0.88 | ALDH1A1 (0.46) | RAB9ANPC1SMN1; SMN2L3MBTL1ALDH1A1 | |
| SCHEMBL12828886 | 0.88 | NAMPT (0.48) | RAB9ANPC1SMN1; SMN2L3MBTL1ALDH1A1 | |
| SCHEMBL12828521 | 0.87 | TP53 (0.46) | RAB9ANPC1SMN1; SMN2L3MBTL1ALDH1A1 | |
| SCHEMBL12828533 | 0.86 | ALPL (0.43) | RAB9ANPC1SMN1; SMN2L3MBTL1ALDH1A1 | |
| SCHEMBL12828881 | 0.83 | ALDH1A1 (0.55) | SMN1; SMN2L3MBTL1ALDH1A1MAPTKDM4E | |
| SCHEMBL12828601 | 0.79 | ALDH1A1 (0.50) | NPC1SMN1; SMN2ALDH1A1ALOX12MAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7915297-B2 | Isoxazole derivatives and use thereof | SK HOLDINGS CO., LTD. (KR) | 2011-03-29 | — | — | US | disclosed |
| US-20090131336-A1 | Isoxazole Derivatives and Use Thereof | SK BIOPHARMACEUTICALS CO., LTD. (KR) | 2009-05-21 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20090131336-A1 | Isoxazole Derivatives and Use Thereof | WNT3A, WNT1, WNT3 | RAB9A 2013/4885NPC1 2242/4885SMN1; SMN2 3980/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.