Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | EGFR | P00533 | 7/20 | 0.42 |
| ▸ | JAK3 | P52333 | 4/20 | 0.41 |
| ▸ | FGFR1 | P11362 | 4/20 | 0.41 |
| ▸ | FGFR2 | P21802 | 3/20 | 0.39 |
| ▸ | FGFR3 | P22607 | 3/20 | 0.39 |
| ▸ | FGFR4 | P22455 | 2/20 | 0.39 |
| ▸ | BTK | Q06187 | 11/20 | 0.39 |
| ▸ | TET3 | O43151 | 1/20 | 0.38 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.38 |
| ▸ | FBXL19 | Q6PCT2 | 1/20 | 0.38 |
| ▸ | CXXC5 | Q7LFL8 | 1/20 | 0.38 |
| ▸ | TET1 | Q8NFU7 | 1/20 | 0.38 |
| ▸ | KDM2B | Q8NHM5 | 1/20 | 0.38 |
| ▸ | CXXC4 | Q9H2H0 | 1/20 | 0.38 |
| ▸ | KDM2A | Q9Y2K7 | 1/20 | 0.38 |
| ▸ | TEC | P42680 | 5/20 | 0.38 |
| ▸ | TXK | P42681 | 3/20 | 0.38 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.38 |
| ▸ | CYP2C8 | P10632 | 1/20 | 0.38 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL12840898 | 0.81 | EGFR (0.49) | EGFRJAK3FGFR1FGFR2FGFR3 | |
| SCHEMBL12840891 | 0.80 | EGFR (0.45) | EGFRFGFR1 | |
| SCHEMBL2826258 | 0.80 | NSD2 (0.42) | FGFR1CYP3A4 | |
| SCHEMBL12840913 | 0.75 | JAK3 (0.48) | EGFRJAK3 | |
| SCHEMBL28787353 | 0.75 | HTR4 (0.46) | KMT2A | |
| SCHEMBL15650533 | 0.71 | L3MBTL3 (0.63) | CYP2C19 | |
| SCHEMBL6155353 | 0.70 | PARP15 (0.43) | KMT2AKDM2BCYP3A4CYP2C19 | |
| SCHEMBL16391119 | 0.70 | PGR (0.41) | KDM2BCYP3A4 | |
| SCHEMBL21338059 | 0.70 | PGR (0.41) | KDM2BCYP3A4 | |
| SCHEMBL2169887 | 0.70 | NSD2 (0.42) | FGFR1KMT2ACYP3A4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2011034907-A2 | PROTEIN KINASE CONJUGATES AND INHIBITORS | AVILA THERAPEUTICS, INC. (US) | 2011-03-24 | — | — | WO | disclosed |