Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | EGFR | P00533 | 3/20 | 0.45 |
| ▸ | KRAS | P01116 | 6/20 | 0.39 |
| ▸ | MAPT | P10636 | 1/20 | 0.39 |
| ▸ | SIGMAR1 | Q99720 | 2/20 | 0.38 |
| ▸ | FGFR1 | P11362 | 1/20 | 0.38 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.38 |
| ▸ | GAA | P10253 | 1/20 | 0.37 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.37 |
| ▸ | PKM | P14618 | 1/20 | 0.37 |
| ▸ | HTR4 | Q13639 | 1/20 | 0.36 |
| ▸ | TEAD1 | P28347 | 1/20 | 0.36 |
| ▸ | LMNA | P02545 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL12840898 | 0.81 | EGFR (0.49) | EGFRFGFR1TEAD1 | |
| SCHEMBL12840918 | 0.80 | EGFR (0.42) | EGFRFGFR1 | |
| SCHEMBL28787353 | 0.79 | HTR4 (0.46) | ALDH1A1HTR4 | |
| SCHEMBL13362107 | 0.73 | ALDH1A1 (0.44) | MAPTALDH1A1GAASMN1; SMN2LMNA | |
| SCHEMBL28787314 | 0.71 | TEAD1 (0.56) | ALDH1A1TEAD1LMNA | |
| SCHEMBL13362051 | 0.70 | ALDH1A1 (0.39) | ALDH1A1GAASMN1; SMN2PKMHTR4 | |
| SCHEMBL28787311 | 0.70 | HSD11B1 (0.52) | ALDH1A1SMN1; SMN2HTR4LMNA | |
| SCHEMBL12840913 | 0.69 | JAK3 (0.48) | EGFRALDH1A1 | |
| SCHEMBL28787352 | 0.69 | MAPKAPK2 (0.51) | HTR4 | |
| SCHEMBL13362035 | 0.68 | ALDH1A1 (0.44) | ALDH1A1LMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2011034907-A2 | PROTEIN KINASE CONJUGATES AND INHIBITORS | AVILA THERAPEUTICS, INC. (US) | 2011-03-24 | — | — | WO | disclosed |