Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HDAC4 | P56524 | 1/20 | 0.38 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.33 |
| ▸ | VEGFA | P15692 | 1/20 | 0.33 |
| ▸ | FLT1 | P17948 | 1/20 | 0.33 |
| ▸ | EGLN1 | Q9GZT9 | 1/20 | 0.33 |
| ▸ | EGLN3 | Q9H6Z9 | 1/20 | 0.33 |
| ▸ | CA1 | P00915 | 1/20 | 0.33 |
| ▸ | CA2 | P00918 | 1/20 | 0.33 |
| ▸ | MRGPRX4 | Q96LA9 | 1/20 | 0.32 |
| ▸ | ELOVL6 | Q9H5J4 | 1/20 | 0.31 |
| ▸ | PDK2 | Q15119 | 1/20 | 0.31 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.31 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.31 |
| ▸ | CCR2 | P41597 | 1/20 | 0.31 |
| ▸ | ORAI1 | Q96D31 | 2/20 | 0.30 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.30 |
| ▸ | MEN1 | O00255 | 1/20 | 0.30 |
| ▸ | GAA | P10253 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL18773293 | 0.96 | HDAC4 (0.36) | HDAC4KDM4EVEGFAFLT1EGLN1 | |
| SCHEMBL12846262 | 0.93 | TTK (0.33) | HDAC4KDM4ECA1CA2ELOVL6 | |
| Fluralaner SCHEMBL8515337 | 0.92 | CA1 (0.32) | HDAC4KDM4ECA1CA2ELOVL6 | |
| Fluralaner SCHEMBL29362559 | 0.92 | CA1 (0.32) | HDAC4KDM4ECA1CA2ELOVL6 | |
| Fluralaner SCHEMBL121934 | 0.92 | CA1 (0.32) | HDAC4KDM4ECA1CA2ELOVL6 | |
| Fluralaner SCHEMBL29399660 | 0.92 | CA1 (0.32) | HDAC4KDM4ECA1CA2ELOVL6 | |
| Fluralaner SCHEMBL8513367 | 0.92 | CA1 (0.32) | HDAC4KDM4ECA1CA2ELOVL6 | |
| SCHEMBL737408 | 0.92 | EGLN1 (0.36) | KDM4EVEGFAFLT1EGLN1EGLN3 | |
| SCHEMBL740369 | 0.92 | CA1 (0.34) | KDM4ECA1CA2ELOVL6KMT2A | |
| SCHEMBL23344168 | 0.92 | GPR139 (0.34) | HDAC4CA1CA2CCR2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 9 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20240239759-A1 | ISOXAZOLINE COMPOSITIONS AND THEIR USE AS ANTIPARASITICS | INTERVET INC. (US) | 2024-07-18 | — | — | US | disclosed |
| EP-3473101-B1 | ISOXAZOLINE COMPOSITIONS AND THEIR USE AS ANTIPARASITICS FOR FELINES | INTERVET INT BV (NL) | 2021-05-12 | — | — | EP | disclosed |
| US-20210061775-A1 | ISOXAZOLINE COMPOSITIONS AND THEIR USE AS ANTIPARASITICS | INTERVET INC. (US) | 2021-03-04 | — | — | US | disclosed |
| EP-3473101-A1 | ISOXAZOLINE COMPOSITIONS AND THEIR USE AS ANTIPARASITICS FOR FELINES | Intervet International B.V. (NL) | 2019-04-24 | — | — | EP | disclosed |
| US-20180155301-A1 | ISOXAZOLINE COMPOSITIONS AND THEIR USE AS ANTIPARASITICS | INTERVET INC. (US) | 2018-06-07 | — | — | US | disclosed |
| US-20160332975-A1 | ISOXAZOLINE COMPOSITIONS AND THEIR USE AS ANTIPARASITICS | INTERVET INC. (US) | 2016-11-17 | — | — | US | disclosed |
| US-20150111936-A1 | ISOXAZOLINE COMPOSITIONS AND THEIR USE AS ANTIPARASITICS | INTERVET INC (US) | 2015-04-23 | — | — | US | disclosed |
| EP-2545777-A1 | Isoxazoline compositions and their use as antiparasitics | Intervet International B.V. (NL) | 2013-01-16 | — | — | EP | disclosed |
| US-20110059988-A1 | ISOXAZOLINE COMPOSITIONS AND THEIR USE AS ANTIPARASITICS | INTERVET INTERNATIONAL B.V. | 2011-03-10 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (6 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20160332975-A1 | ISOXAZOLINE COMPOSITIONS AND THEIR USE AS ANTIPARASITICS | PRDX5, TUBA3C, TUBA1C | HDAC4 504/4885KDM4E 1217/4885VEGFA 4831/4885 |
| US-20210061775-A1 | ISOXAZOLINE COMPOSITIONS AND THEIR USE AS ANTIPARASITICS | PRDX5, TUBA3C, TUBA1C | HDAC4 504/4885KDM4E 1217/4885VEGFA 4831/4885 |
| US-20180155301-A1 | ISOXAZOLINE COMPOSITIONS AND THEIR USE AS ANTIPARASITICS | PRDX5, TUBA3C, TUBA1C | HDAC4 504/4885KDM4E 1217/4885VEGFA 4831/4885 |
| US-20150111936-A1 | ISOXAZOLINE COMPOSITIONS AND THEIR USE AS ANTIPARASITICS | PRDX5, TUBA3C, EPX | HDAC4 459/4885KDM4E 1249/4885VEGFA 4833/4885 |
| US-20240239759-A1 | ISOXAZOLINE COMPOSITIONS AND THEIR USE AS ANTIPARASITICS | PRDX5, TUBA3C, TUBA1C | HDAC4 504/4885KDM4E 1217/4885VEGFA 4831/4885 |
| US-20110059988-A1 | ISOXAZOLINE COMPOSITIONS AND THEIR USE AS ANTIPARASITICS | PRDX5, TUBA3C, AADAC | HDAC4 411/4885KDM4E 1064/4885VEGFA 4842/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.