Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | BHMT | Q93088 | 11/20 | 0.70 |
| ▸ | BHMT2 | Q9H2M3 | 1/20 | 0.59 |
| ▸ | NOS2 | P35228 | 2/20 | 0.54 |
| ▸ | NOS3 | P29474 | 1/20 | 0.54 |
| ▸ | NOS1 | P29475 | 1/20 | 0.54 |
| ▸ | GRIK1 | P39086 | 2/20 | 0.53 |
| ▸ | GRIK2 | Q13002 | 2/20 | 0.53 |
| ▸ | GMNN | O75496 | 1/20 | 0.52 |
| ▸ | TP53 | P04637 | 1/20 | 0.52 |
| ▸ | POLB | P06746 | 1/20 | 0.52 |
| ▸ | MAPT | P10636 | 1/20 | 0.52 |
| ▸ | THRB | P10828 | 1/20 | 0.52 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.52 |
| ▸ | BLM | P54132 | 1/20 | 0.52 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.52 |
| ▸ | SLC1A2 | P43004 | 2/20 | 0.50 |
| ▸ | SLC1A1 | P43005 | 2/20 | 0.50 |
| ▸ | SLC1A3 | P43003 | 1/20 | 0.47 |
| ▸ | CES2 | O00748 | 1/20 | 0.47 |
| ▸ | NOD1 | Q9Y239 | 1/20 | 0.47 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL11575012 | 1.00 | BHMT (0.70) | BHMTBHMT2NOS2NOS3NOS1 | |
| SCHEMBL2367837 | 1.00 | BHMT (0.70) | BHMTBHMT2NOS2NOS3NOS1 | |
| SCHEMBL18832139 | 1.00 | BHMT (0.70) | BHMTBHMT2NOS2NOS3NOS1 | |
| SCHEMBL18832141 | 1.00 | BHMT (0.70) | BHMTBHMT2NOS2NOS3NOS1 | |
| SCHEMBL18832137 | 1.00 | BHMT (0.70) | BHMTBHMT2NOS2NOS3NOS1 | |
| SCHEMBL18832133 | 0.98 | BHMT (0.69) | BHMTBHMT2NOS2NOS3NOS1 | |
| SCHEMBL60520 | 0.93 | BHMT (0.66) | BHMTBHMT2NOS2NOS3NOS1 | |
| SCHEMBL4955426 | 0.93 | BHMT (0.66) | BHMTBHMT2NOS2NOS3NOS1 | |
| SCHEMBL1285565 | 0.93 | BHMT (0.66) | BHMTBHMT2NOS2NOS3NOS1 | |
| SCHEMBL28042282 | 0.89 | BHMT (0.60) | BHMTBHMT2NOS2NOS3NOS1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8329745-B2 | Small molecule inhibitors of ghrelin O-acyltransferase | BOARD OF REGENTS, THE UNIVERSITY OF TEXAS SYSTEM (US) | 2012-12-11 | — | — | US | disclosed |
| US-20110318807-A1 | Small Molecule Inhibitors of Ghrelin O-Acyltransferase | UNIVERSITY OF TEXAS, BOARD OF REGENTS | 2011-12-29 | — | — | US | disclosed |
| US-8013015-B2 | Small molecule inhibitors of ghrelin O-acyltransferase | BOARD OF REGENTS, THE UNIVERSITY OF TEXAS SYSTEM (US) | 2011-09-06 | — | — | US | disclosed |
| US-20100086955-A1 | Small Molecule Inhibitors of Ghrelin O-Acyltransferase | UNIVERSITY OF TEXAS, BOARD OF REGENTS | 2010-04-08 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20110318807-A1 | Small Molecule Inhibitors of Ghrelin O-Acyltransferase | MBOAT4, MOGAT2, DGAT1 | BHMT 766/4885BHMT2 1014/4885NOS2 2371/4885 |
| US-20100086955-A1 | Small Molecule Inhibitors of Ghrelin O-Acyltransferase | MBOAT4, MOGAT2, DGAT1 | BHMT 766/4885BHMT2 1014/4885NOS2 2371/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.