Known targets — ChEMBL curated mechanism
DHFRGARTPTGFRPTGIRPTGS1PTGS2TUBA1ATUBA1BTUBA1CTUBA3CTUBA3ETUBA4ATUBBTUBB1TUBB2ATUBB2BTUBB3TUBB4ATUBB4BTUBB6TUBB8envmurAthyA
The experimentally established mechanism targets of Tromethamine. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 5)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MEN1 | O00255 | 1/20 | 0.83 |
| ▸ | LMNA | P02545 | 1/20 | 0.83 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.83 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.31 |
| ▸ | POLB | P06746 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Tromethamine SCHEMBL28266658 | 0.92 | MEN1 (0.83) | MEN1LMNAKMT2AKDM4EPOLB | |
| Tromethamine SCHEMBL30753541 | 0.92 | MEN1 (0.83) | MEN1LMNAKMT2AKDM4EPOLB | |
| Tromethamine SCHEMBL20658226 | 0.92 | MEN1 (0.83) | MEN1LMNAKMT2AKDM4EPOLB | |
| Tromethamine SCHEMBL1526047 | 0.92 | — | — | |
| Tromethamine SCHEMBL5012318 | 0.92 | MEN1 (0.83) | MEN1LMNAKMT2AKDM4EPOLB | |
| Tromethamine SCHEMBL17484 | 0.91 | MEN1 (1.00) | MEN1LMNAKMT2AKDM4EPOLB | |
| Tromethamine SCHEMBL975 | 0.91 | — | — | |
| Tromethamine SCHEMBL3696191 | 0.91 | — | — | |
| Tromethamine SCHEMBL6063594 | 0.87 | — | — | |
| Tromethamine SCHEMBL2035496 | 0.87 | — | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 38 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-114279989-A | Method and system for measuring anti-Xa factor titer of low-molecular-weight heparin calcium injection | 江苏大同盟制药有限公司 | 2022-04-05 | — | — | CN | claimed |
| JP-60253869-A | — | — | None | — | — | JP | disclosed |
| CN-114609379-A | Detection reagent and detection method for 3-methoxytyramine | 郑州安图生物工程股份有限公司 | 2022-06-10 | — | — | CN | disclosed |
| CN-114279989-A | Method and system for measuring anti-Xa factor titer of low-molecular-weight heparin calcium injection | 江苏大同盟制药有限公司 | 2022-04-05 | — | — | CN | disclosed |
| CN-114279989-A | Method and system for measuring anti-Xa factor titer of low-molecular-weight heparin calcium injection | 江苏大同盟制药有限公司 | 2022-04-05 | — | — | CN | disclosed |
| CN-114126584-A | Recombinant protein stabilizing formulations | 联合化学实验室有限公司 | 2022-03-01 | — | — | CN | disclosed |
| CN-106749769-B | Improved low molecular weight heparin calcium bulk drug and preparation thereof | 海南通用同盟药业有限公司 | 2021-08-24 | — | — | CN | disclosed |
| US-11060112-B2 | Producer cells for replication competent retroviral vectors | DENOVO BIOPHARMA LLC (US) | 2021-07-13 | — | — | US | disclosed |
| CN-112578119-A | Methoxy adrenalin luminescence immunoassay kit | 郑州安图生物工程股份有限公司 | 2021-03-30 | — | — | CN | disclosed |
| CN-112578132-A | Methoxy norepinephrine luminescent immunoassay kit | 郑州安图生物工程股份有限公司 | 2021-03-30 | — | — | CN | disclosed |
| EP-1877804-A1 | METHOD FOR DETERMINATION OF GLYCOPROTEIN IBALPHA (GPIBALPHA) PROTEIN | Wyeth (US) | 2008-01-16 | — | — | EP | disclosed |
| WO-2006116167-A9 | METHOD FOR DETERMINATION OF GLYCOPROTEIN IBALPHA (GPIBALPHA) PROTEIN | WYETH CORP (US) | 2007-11-29 | — | — | WO | disclosed |
| WO-2006116167-A1 | METHOD FOR DETERMINATION OF GLYCOPROTEIN IBALPHA (GPIBALPHA) PROTEIN | WYETH (US) | 2006-11-02 | — | — | WO | disclosed |
| CN-1592791-A | Phytases, nucleic acids encoding them and methods of making and using them | DIVERSA CORP (US) | 2005-03-09 | — | — | CN | disclosed |
| US-20030073148-A1 | ANTIBODIES BINDING TO HUMAN AIRWAY TRYPSIN-LIKE PROTEASE AND METHODS FOR UTILIZING THE SAME | TEIJIN LIMITED (JP) | 2003-04-17 | — | — | US | disclosed |
| US-6444791-B1 | THERAPY FOR VISION DEFECTS; ADMINISTERING MACROGLOBULINS | K-QUAY ENTERPRISES, LLC | 2002-09-03 | — | — | US | disclosed |
| EP-1231936-A2 | METHODS AND COMPOSITIONS FOR TREATMENT OF KERATOCONUS USING PROTEASE INHIBITORS | K-Quay Enterprises, LLC (US) | 2002-08-21 | — | — | EP | disclosed |
| EP-1152057-A1 | ANTIBODY BINDING TO HUMAN AIRWAY TRYPSIN-LIKE ENZYME AND UTILIZATION THEREOF | TEIJIN LIMITED (JP) | 2001-11-07 | — | — | EP | disclosed |
| WO-2001030380-A2 | METHODS AND COMPOSITIONS FOR TREATMENT OF KERATOCONUS USING PROTEASE INHIBITORS | K-QUAY ENTERPRISES, LLC (US) | 2001-05-03 | — | — | WO | disclosed |
| JP-S60253869-A | REAGENT FOR MESURING ANTI-ARTIFICIAL NUCLEUS ANTIGEN ANTIBODY | MITSUI PHARMACEUT INC | 1985-12-14 | — | — | JP | disclosed |