Known targets — ChEMBL curated mechanism
DHFRGARTPTGFRPTGIRPTGS1PTGS2TUBA1ATUBA1BTUBA1CTUBA3CTUBA3ETUBA4ATUBBTUBB1TUBB2ATUBB2BTUBB3TUBB4ATUBB4BTUBB6TUBB8envmurAthyA
The experimentally established mechanism targets of Tromethamine. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
⚠ Novel chemotype — no close known analogue (best Tanimoto < 0.3). Unexplored chemical space relative to ChEMBL.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Tromethamine SCHEMBL7091147 | 0.96 | — | — | |
| Tromethamine SCHEMBL10437676 | 0.96 | — | — | |
| Tromethamine SCHEMBL5012318 | 0.92 | MEN1 (0.83) | — | |
| Tromethamine SCHEMBL28266658 | 0.92 | MEN1 (0.83) | — | |
| Tromethamine SCHEMBL11131573 | 0.92 | — | — | |
| Tromethamine SCHEMBL1285696 | 0.92 | MEN1 (0.83) | — | |
| Tromethamine SCHEMBL30753541 | 0.92 | MEN1 (0.83) | — | |
| Tromethamine SCHEMBL975 | 0.91 | — | — | |
| Tromethamine SCHEMBL3696191 | 0.91 | — | — | |
| Tromethamine SCHEMBL17484 | 0.91 | MEN1 (1.00) | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 213 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-122080742-A | Ultralow-VOC (volatile organic compound) graphene anti-corrosion curing coating and preparation method thereof | — | 2026-05-26 | — | — | CN | disclosed |
| CN-122035964-A | Large-particle-size high-capacity monocrystal ternary positive electrode material and preparation method and application thereof | 扬州虹一新材料有限公司 | 2026-05-15 | — | — | CN | disclosed |
| US-20260117184-A1 | SYSTEM AND METHOD TO DIRECT THE DIFFERENTIATION OF PLURIPOTENT STEM CELL-DERIVED ODONTOBLASTS | UNIVERSITY OF WASHINGTON (US) | 2026-04-30 | — | — | US | disclosed |
| US-20260060930-A1 | New crystalline Forms, new pharmaceutical Composition and Dose Regimen of a Dipeptidyl peptidase I inhibitor for the Treatment of Patients with Bronchiectasis or other DPP-I mediated Diseases | BOEHRINGER INGELHEIM INT (DE) | 2026-03-05 | — | — | US | disclosed |
| US-20250288624-A1 | LONG-TERM STABILIZATION, FORMULATION AND TABLETING OF LIVE MICROBIAL CELLS | MASSACHUSETTS INSTITUTE OF TECHNOLOGY (US) | 2025-09-18 | — | — | US | disclosed |
| EP-4605744-A1 | TREATMENT OF MICROBIAL INFECTIONS DIAGNOSED USING THE BIOMARKER D-LACTATE | Heraeus Medical GmbH (DE) | 2025-08-27 | — | — | EP | disclosed |
| US-12391728-B2 | Full flow-through process for purifying recombinant proteins | SANOFI (FR) | 2025-08-19 | — | — | US | disclosed |
| US-20250185669-A1 | ANTI-VIRAL PAINTS AND COATINGS AND ARTICLES COMPRISING SAME | Reactive Surfaces Ltd., LLP (US) | 2025-06-12 | — | — | US | disclosed |
| CN-115308010-B | Antibody protective agent and blood collection tube | 威高集团有限公司 | 2025-05-23 | — | — | CN | disclosed |
| CN-120000624-A | Application of tris (hydroxymethyl) aminomethane salt in preparation of medicines for treating metabolic alkalosis | 北京畅盛医药科技有限公司 | 2025-05-16 | — | — | CN | disclosed |
| WO-2001017942-A1 | AMIDES AS INHIBITORS FOR PYRUVATE DEHYDROGENASE | ASTRAZENECA AB (SE) | 2001-03-15 | — | — | WO | disclosed |
| WO-2001017955-A2 | HYDROXYACETAMIDOBENZENESULPHONAMIDE DERIVATIVES | ASTRAZENECA AB (SE) | 2001-03-15 | — | — | WO | disclosed |
| WO-2001017956-A1 | SUBSTITUTED N-PHENYL 2-HYDROXY-2-METHYL-3,3,3-TRIFLUOROPROPANAMIDE DERIVATIVES WHICH ELEVATE PYRUVATE DEHYDROGENASE ACTIVITY | ASTRAZENECA AB (SE) | 2001-03-15 | — | — | WO | disclosed |
| EP-1082110-A1 | USE OF COMPOUNDS FOR THE ELEVATION OF PYRUVATE DEHYDROGENASE ACTIVITY | AstraZeneca AB (SE) | 2001-03-14 | — | — | EP | disclosed |
| EP-1064274-A1 | BENZENESULFONAMIDE DERIVATIVES AND THEIR USE AS MEDICAMENTS | AstraZeneca AB (SE) | 2001-01-03 | — | — | EP | disclosed |
| EP-1059927-A1 | CHEMICAL COMPOUNDS AND THEIR USE TO ELEVATE PYRUVATE DEHYDROGENASE ACTIVITY | AstraZeneca AB (SE) | 2000-12-20 | — | — | EP | disclosed |
| WO-1999062506-A1 | USE OF COMPOUNDS FOR THE ELEVATION OF PYRUVATE DEHYDROGENASE ACTIVITY | ASTRAZENECA AB (SE) | 1999-12-09 | — | — | WO | disclosed |
| WO-1999062873-A1 | BENZENESULPHONAMIDE DERIVATIVES AS PYRUVATE DEHYDROGENASE ACTIVATORS | ASTRAZENECA AB (SE) | 1999-12-09 | — | — | WO | disclosed |
| WO-1999047508-A1 | BENZENESULFONAMIDE-DERIVATIVES AND THEIR USE AS MEDICAMENTS | ASTRAZENECA AB (SE) | 1999-09-23 | — | — | WO | disclosed |
| WO-1999044618-A1 | CHEMICAL COMPOUNDS AND THEIR USE TO ELEVATE PYRUVATE DEHYDROGENASE ACTIVITY | ASTRAZENECA AB (SE) | 1999-09-10 | — | — | WO | disclosed |