Known targets — ChEMBL curated mechanism
DHFRGARTPTGFRPTGIRPTGS1PTGS2TUBA1ATUBA1BTUBA1CTUBA3CTUBA3ETUBA4ATUBBTUBB1TUBB2ATUBB2BTUBB3TUBB4ATUBB4BTUBB6TUBB8envmurAthyA
The experimentally established mechanism targets of Tromethamine. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MEN1 | O00255 | 1/20 | 1.00 |
| ▸ | LMNA | P02545 | 1/20 | 1.00 |
| ▸ | KMT2A | Q03164 | 1/20 | 1.00 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.33 |
| ▸ | POLB | P06746 | 1/20 | 0.33 |
| ▸ | TNNC1 | P63316 | 5/20 | 0.30 |
| ▸ | SGPL1 | O95470 | 1/20 | 0.30 |
| ▸ | S1PR4 | O95977 | 1/20 | 0.30 |
| ▸ | S1PR1 | P21453 | 1/20 | 0.30 |
| ▸ | GPR183 | P32249 | 1/20 | 0.30 |
| ▸ | CERS2 | Q96G23 | 1/20 | 0.30 |
| ▸ | S1PR3 | Q99500 | 1/20 | 0.30 |
| ▸ | S1PR5 | Q9H228 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Tromethamine SCHEMBL3696191 | 1.00 | — | — | |
| Tromethamine SCHEMBL975 | 1.00 | — | — | |
| Tromethamine SCHEMBL6427079 | 0.95 | — | — | |
| Tromethamine SCHEMBL2313359 | 0.95 | MEN1 (0.91) | MEN1LMNAKMT2AKDM4EPOLB | |
| Tromethamine SCHEMBL4388579 | 0.95 | — | — | |
| Tromethamine SCHEMBL7126002 | 0.95 | — | — | |
| Tromethamine SCHEMBL9298764 | 0.95 | — | — | |
| Tromethamine SCHEMBL2263148 | 0.95 | MEN1 (0.91) | MEN1LMNAKMT2AKDM4EPOLB | |
| Tromethamine SCHEMBL6063594 | 0.95 | — | — | |
| Tromethamine SCHEMBL2035496 | 0.95 | — | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Appears in 2883 patents — a generic fragment claimed broadly, so it's down-weighted as IP noise. Top by claim status then date:
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-117923449-A | Method for promoting synthesis of blue iron ore by adding catalpa ovata fruit biochar | 北京工业大学 | 2024-04-26 | — | — | CN | claimed |
| EP-3651737-B1 | EMBOLIC MICROSPHERES | VARIAN MED SYS INC (US) | 2023-05-10 | — | — | EP | claimed |
| EP-3943493-B1 | COMPLEX OF GADOLINIUM AND A CHELATING LIGAND DERIVED FROM DIASTEREOISOMERICALLY ENRICHED PCTA AND METHOD FOR PREPARING AND PURIFYING SAME | GUERBET SA (FR) | 2023-04-19 | — | — | EP | claimed |
| EP-2990837-B1 | USE OF A PACKAGING SOLUTION FOR CONTACT LENSES | ALCON INC (CH) | 2023-04-12 | — | — | EP | claimed |
| CN-114794082-B | Antifreeze protein-containing diluent for improving preservation quality of chicken essence and preparation method thereof | 贵州省种畜禽种质测定中心 | 2022-10-18 | — | — | CN | claimed |
| CN-109642153-B | Chemiluminescent substrate | 拜克门寇尔特公司 | 2022-08-19 | — | — | CN | claimed |
| EP-3656215-B1 | STABILIZATION OF THROMBOCYTES AT AMBIENT TEMPERATURES | BIOMATRICA INC (US) | 2021-08-04 | — | — | EP | claimed |
| WO-2021000067-A1 | CELL-BINDING MOLECULE-TUBULYSIN DERIVATIVE CONJUGATE AND PREPARATION METHOD THEREFOR | 杭州多禧生物科技有限公司 | 2021-01-07 | — | — | WO | claimed |
| WO-2019178587-A1 | PURIFICATION OF TARGET MOLECULES | BIO-RAD LABORATORIES, INC. (US) | 2019-09-19 | — | — | WO | claimed |
| EP-3216793-B1 | TRIAZINE COMPOUNDS AS P13 KINASE AND MTOR INHIBITORS | WYETH LLC (US) | 2019-03-27 | — | — | EP | claimed |
| EP-2185951-A1 | CONTACT LENS PRODUCTS | Novartis Ag (CH) | 2010-05-19 | — | — | EP | claimed |
| EP-1923469-B1 | Method of detecting mild impaired glucose tolerance or insulin hyposecretion | ASAHI KASEI PHARMA CORP (JP) | 2009-12-02 | — | — | EP | claimed |
| WO-2009032132-A1 | CONTACT LENS PRODUCTS | NOVARTIS AG (CH) | 2009-03-12 | — | — | WO | claimed |
| US-20090059165-A1 | Contact lens products | ALCON INC. (CH) | 2009-03-05 | — | — | US | claimed |
| EP-1516021-B1 | PRINTING PROCESS USING SPECIFIED AZO COMPOUNDS | FUJIFILM IMAGING COLORANTS LTD (GB) | 2006-05-17 | — | — | EP | claimed |
| EP-1187601-B1 | NOVEL PREPARATION AND ADMINISTRATION FORM COMPRISING AN ACID-LABILE PROTON PUMP INHIBITOR | ALTANA PHARMA AG (DE) | 2005-07-27 | — | — | EP | claimed |
| US-6777402-B2 | ACIDIC ALCOHOLYSIS OF BIOLOGICAL RAW MATERIAL GIVING CRYSTALLINE ALKYL PHEOPHORBIDE; CONVERSION OF ALKYL PHEOPHORBIDE INTO AN ACIDIC PORPHYRIN; REACTION OF THE ACIDIC PORPHYRIN WITH A HYDROPHYLIC ORGANIC AMINE | CERAMOPTEC INDUSTRIES, INC. | 2004-08-17 | — | — | US | claimed |
| WO-1998032862-A9 | L-ALANINE DEHYDROGENASE OF MYCOBACTERIUM MARINUM | — | 1998-12-23 | — | — | WO | claimed |
| WO-1998032862-A2 | L-ALANINE DEHYDROGENASE OF MYCOBACTERIUM MARINUM | FLOHE LEOPOLD (DE) | 1998-07-30 | — | — | WO | claimed |
| EP-0571593-B1 | NEW NON IONIC IODIZED AGENTS FOR X-RAY CONTRASTING, METHOD FOR PREPARING THEM AND GALENICAL COMPOSITIONS CONTAINING THEM | INVEST JUSTESA IMAGEN S A CENT (ES) | 1996-10-30 | — | — | EP | claimed |