Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KCNH2 | Q12809 | 1/20 | 0.52 |
| ▸ | STS | P08842 | 5/20 | 0.48 |
| ▸ | CA2 | P00918 | 4/20 | 0.48 |
| ▸ | CA9 | Q16790 | 4/20 | 0.48 |
| ▸ | CA12 | O43570 | 2/20 | 0.48 |
| ▸ | CA1 | P00915 | 2/20 | 0.48 |
| ▸ | CCR1 | P32246 | 1/20 | 0.48 |
| ▸ | CHRM3 | P20309 | 1/20 | 0.48 |
| ▸ | NPC1 | O15118 | 1/20 | 0.46 |
| ▸ | RAB9A | P51151 | 1/20 | 0.46 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.46 |
| ▸ | GNAI3 | P08754 | 2/20 | 0.44 |
| ▸ | GNAO1 | P09471 | 2/20 | 0.44 |
| ▸ | GNAI1 | P63096 | 2/20 | 0.44 |
| ▸ | HTR4 | Q13639 | 1/20 | 0.44 |
| ▸ | CARM1 | Q86X55 | 1/20 | 0.44 |
| ▸ | PRMT6 | Q96LA8 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6154880 | 0.81 | POLB (0.59) | — | |
| Benzamide SCHEMBL10720284 | 0.80 | KCNH2 (0.64) | KCNH2CHRM3 | |
| Benzamide SCHEMBL10723892 | 0.80 | KCNH2 (0.64) | KCNH2CHRM3 | |
| SCHEMBL8608140 | 0.77 | CA12 (0.67) | KCNH2CA2CA9CA12CA1 | |
| SCHEMBL6153555 | 0.76 | LTA4H (0.66) | KCNH2 | |
| SCHEMBL11938971 | 0.76 | DRD2 (0.54) | CA2CA9CA12CA1SMN1; SMN2 | |
| SCHEMBL27932778 | 0.76 | SYK (0.48) | — | |
| SCHEMBL16256981 | 0.76 | CARM1 (0.68) | KCNH2CA2CA9CA12CA1 | |
| SCHEMBL27669922 | 0.76 | GNAI3 (0.54) | KCNH2CCR1GNAI3GNAO1GNAI1 | |
| Hydrochloric Acid SCHEMBL6157025 | 0.75 | LTA4H (0.65) | KCNH2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 18 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1697307-B1 | OPIOID RECEPTOR ANTAGONISTS | LILLY CO ELI (US) | 2014-03-12 | — | — | EP | disclosed |
| EP-2208727-B1 | Diaryl ethers as opioid receptor antagonist | LILLY CO ELI (US) | 2012-08-29 | — | — | EP | disclosed |
| US-20120088756-A1 | Methods for Regulating Neurotransmitter Systems by Inducing Counteradaptations | MICHALOW ALEXANDER (US) | 2012-04-12 | — | — | US | disclosed |
| US-20100234360-A1 | Methods for Regulating Neurotransmitter Systems by Inducing Counteradaptations | MICHALOW ALEXANDER | 2010-09-16 | — | — | US | disclosed |
| EP-1809104-A4 | METHODS FOR REGULATING NEUROTRANSMITTER SYSTEMS BY INDUCING COUNTERADAPTATIONS | MICHALOW ALEXANDER (US) | 2009-04-29 | — | — | EP | disclosed |
| EP-1562595-B1 | DIARYL ETHERS AS OPIOID RECEPTOR ANTAGONISTS | LILLY CO ELI (US) | 2008-05-21 | — | — | EP | disclosed |
| CN-101065014-A | Method for regulating neurotransmitter systems by inducing counteradaptation | ALEXANDER MICHALOW (US) | 2007-10-31 | — | — | CN | disclosed |
| EP-1809104-A2 | METHODS FOR REGULATING NEUROTRANSMITTER SYSTEMS BY INDUCING COUNTERADAPTATIONS | Michalow, Alexander (US) | 2007-07-25 | — | — | EP | disclosed |
| WO-2006034343-A2 | methods for regulating neurotransmitter systems by inducing counteradaptationS | MICHALOW ALEXANDER (US) | 2006-03-30 | — | — | WO | disclosed |
| US-20060069086-A1 | Methods for regulating neurotransmitter systems by inducing counteradaptations | MICHALOW ALEXANDER | 2006-03-30 | — | — | US | disclosed |
| EP-1049676-B1 | 4- ARYL(PIPERIDIN-4-YL)] AMINOBENZAMIDES WHICH BIND TO THE DELTA-OPIOID RECEPTOR | ORTHO MCNEIL PHARM INC (US) | 2005-10-12 | — | — | EP | disclosed |
| US-6835840-B2 | Process for the preparation diaryl-4-amino-piperidinyl compounds | ASTRAZENECA AB (SE) | 2004-12-28 | — | — | US | disclosed |
| US-20040068112-A1 | Process for the preparation diaryl-4-amino-piperidinyl compounds | ASTRAZENECA AB (SE) | 2004-04-08 | — | — | US | disclosed |
| US-6436959-B1 | DELTA-OPIOID RECEPTOR AGONISTS/ANTAGONISTS, ANALGESICS | ORTHO-MCNEIL PHARMACEUTICAL, INC. | 2002-08-20 | — | — | US | disclosed |
| US-6436959-B1 | DELTA-OPIOID RECEPTOR AGONISTS/ANTAGONISTS, ANALGESICS | ORTHO-MCNEIL PHARMACEUTICAL, INC. | 2002-08-20 | — | — | US | disclosed |
| US-6436959-B1 | DELTA-OPIOID RECEPTOR AGONISTS/ANTAGONISTS, ANALGESICS | ORTHO-MCNEIL PHARMACEUTICAL, INC. | 2002-08-20 | — | — | US | disclosed |
| EP-1049676-A1 | 4- ARYL(PIPERIDIN-4-YL)] AMINOBENZAMIDES WHICH BIND TO THE DELTA-OPIOID RECEPTOR | Ortho-Mcneil Pharmaceutical, Inc. (US) | 2000-11-08 | — | — | EP | disclosed |
| WO-1999033806-A1 | 4-[ARYL(PIPERIDIN-4-YL)] AMINOBENZAMIDES WHICH BIND TO THE DELTA-OPIOID RECEPTOR | ORTHO-MCNEIL PHARMACEUTICAL, INC. (US) | 1999-07-08 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20040068112-A1 | Process for the preparation diaryl-4-amino-piperidinyl compounds | DDC, AADAC, ABL1 | KCNH2 932/4885STS 2604/4885CA2 4457/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.