Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MEN1 | O00255 | 1/20 | 0.48 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.48 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.47 |
| ▸ | GAA | P10253 | 1/20 | 0.47 |
| ▸ | NAAA | Q02083 | 2/20 | 0.45 |
| ▸ | TSHR | P16473 | 1/20 | 0.45 |
| ▸ | PREP | P48147 | 2/20 | 0.45 |
| ▸ | ADORA1 | P30542 | 1/20 | 0.45 |
| ▸ | ADORA2B | P29275 | 1/20 | 0.45 |
| ▸ | NPC1 | O15118 | 1/20 | 0.44 |
| ▸ | RAB9A | P51151 | 1/20 | 0.44 |
| ▸ | CPB1 | P15086 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4697243 | 0.85 | SCN9A (0.50) | ALDH1A1GAA | |
| SCHEMBL7196152 | 0.81 | ALDH1A1 (0.41) | MEN1KMT2AALDH1A1GAANAAA | |
| SCHEMBL7196147 | 0.80 | ALDH1A1 (0.39) | MEN1KMT2AALDH1A1GAANAAA | |
| SCHEMBL7807134 | 0.76 | GAA (0.44) | ALDH1A1GAANAAATSHRPREP | |
| SCHEMBL7807139 | 0.76 | GAA (0.44) | ALDH1A1GAANAAATSHRPREP | |
| SCHEMBL9541279 | 0.76 | ALDH1A1 (0.52) | ALDH1A1GAANAAATSHRCPB1 | |
| SCHEMBL12345121 | 0.75 | NAAA (0.50) | ALDH1A1GAANAAATSHRPREP | |
| SCHEMBL13017770 | 0.75 | NAAA (0.50) | ALDH1A1GAANAAATSHRPREP | |
| SCHEMBL28513970 | 0.74 | ALDH1A1 (0.52) | MEN1KMT2AALDH1A1GAANAAA | |
| SCHEMBL7811138 | 0.73 | ALDH1A1 (0.45) | MEN1KMT2AALDH1A1GAANAAA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7893096-B2 | For example, N-methyl-4-[(2-{[2-(1-methylethyl)phenyl]amino}-1 H-benzimidazol-5-yl)oxy]pyridine-2-carboxamide; administering the compounds alone or in combination with another agent for the treatment of cancer, infectious diseases and/or allergies/asthma | NOVARTIS VACCINES AND DIAGNOSTICS, INC. (US) | 2011-02-22 | — | — | US | disclosed |
| US-7893096-B2 | For example, N-methyl-4-[(2-{[2-(1-methylethyl)phenyl]amino}-1 H-benzimidazol-5-yl)oxy]pyridine-2-carboxamide; administering the compounds alone or in combination with another agent for the treatment of cancer, infectious diseases and/or allergies/asthma | NOVARTIS VACCINES AND DIAGNOSTICS, INC. (US) | 2011-02-22 | — | — | US | disclosed |