Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PTGS1 | P23219 | 2/20 | 0.39 |
| ▸ | GABRA1 | P14867 | 1/20 | 0.39 |
| ▸ | GABRB2 | P47870 | 1/20 | 0.39 |
| ▸ | TRPA1 | O75762 | 1/20 | 0.39 |
| ▸ | CACNA1C | Q13936 | 1/20 | 0.39 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.36 |
| ▸ | LMNA | P02545 | 2/20 | 0.33 |
| ▸ | FABP3 | P05413 | 2/20 | 0.33 |
| ▸ | FABP4 | P15090 | 2/20 | 0.33 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.33 |
| ▸ | GAA | P10253 | 1/20 | 0.33 |
| ▸ | ALOX12 | P18054 | 1/20 | 0.33 |
| ▸ | HTT | P42858 | 1/20 | 0.33 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.33 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.33 |
| ▸ | POLQ | O75417 | 1/20 | 0.33 |
| ▸ | MAPT | P10636 | 1/20 | 0.33 |
| ▸ | PTGS2 | P35354 | 1/20 | 0.32 |
| ▸ | FABP5 | Q01469 | 1/20 | 0.32 |
| ▸ | CRHR1 | P34998 | 2/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL803445 | 0.83 | POLB (0.38) | PTGS1GABRA1GABRB2TRPA1CACNA1C | |
| SCHEMBL27931949 | 0.79 | KDM4E (0.37) | MAPK1LMNAALDH1A1GAAHTT | |
| SCHEMBL16477747 | 0.77 | PTGS1 (0.39) | PTGS1GABRA1GABRB2TRPA1CACNA1C | |
| SCHEMBL10204242 | 0.76 | GABRA1 (0.38) | PTGS1GABRA1GABRB2TRPA1CACNA1C | |
| SCHEMBL19007329 | 0.74 | NOS3 (0.43) | PTGS1GABRA1GABRB2TRPA1CACNA1C | |
| SCHEMBL10204247 | 0.73 | LMNA (0.33) | PTGS1GABRA1GABRB2TRPA1CACNA1C | |
| SCHEMBL3030918 | 0.73 | ALDH1A1 (0.40) | PTGS1TRPA1CACNA1CMAPK1LMNA | |
| SCHEMBL10204248 | 0.73 | NOS2 (0.54) | MAPK1ALDH1A1GAAALOX12HTT | |
| SCHEMBL10204245 | 0.73 | LMNA (0.38) | MAPK1LMNAALDH1A1HTTMAPT | |
| SCHEMBL30228949 | 0.73 | ALDH1A1 (0.40) | PTGS1TRPA1CACNA1CMAPK1LMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20190084988-A1 | WDR5 INHIBITORS AND MODULATORS | VANDERBILT UNIVERSITY | 2019-03-21 | — | — | US | disclosed |
| US-8394960-B2 | Thiazole carboxamide derivatives and their use to treat cancer | MERCK SHARP & DOHME CORP. (US) | 2013-03-12 | — | — | US | disclosed |
| US-20110044940-A1 | Thiazole Carboxamide Derivatives and Their Use to Treat Cancer | SCHERING CORPORATION | 2011-02-24 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20190084988-A1 | WDR5 INHIBITORS AND MODULATORS | WDR5, WDR1, WDR3 | PTGS1 3235/4885GABRA1 2682/4885GABRB2 2703/4885 |
| US-20110044940-A1 | Thiazole Carboxamide Derivatives and Their Use to Treat Cancer | LCK, TEC, MTOR | PTGS1 1507/4885GABRA1 4351/4885GABRB2 4140/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.