Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KYNU | Q16719 | 1/20 | 0.60 |
| ▸ | ELANE | P08246 | 2/20 | 0.55 |
| ▸ | TRPM8 | Q7Z2W7 | 1/20 | 0.54 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.54 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.54 |
| ▸ | CTRB1 | P17538 | 2/20 | 0.52 |
| ▸ | ATM | Q13315 | 2/20 | 0.52 |
| ▸ | PRTN3 | P24158 | 2/20 | 0.52 |
| ▸ | ACE2 | Q9BYF1 | 1/20 | 0.51 |
| ▸ | CTSK | P43235 | 2/20 | 0.50 |
| ▸ | TACR1 | P25103 | 1/20 | 0.50 |
| ▸ | KLK1 | P06870 | 1/20 | 0.50 |
| ▸ | MME | P08473 | 1/20 | 0.49 |
| ▸ | ECE1 | P42892 | 1/20 | 0.49 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1068881 | 0.91 | KYNU (0.60) | KYNUELANETRPM8ALDH1A1ALOX15 | |
| SCHEMBL18082610 | 0.89 | KYNU (0.60) | KYNUELANETRPM8ALDH1A1ALOX15 | |
| SCHEMBL29678939 | 0.87 | KYNU (0.62) | KYNUELANETRPM8ALDH1A1ALOX15 | |
| SCHEMBL269404 | 0.87 | KYNU (0.62) | KYNUELANETRPM8ALDH1A1ALOX15 | |
| SCHEMBL187849 | 0.87 | KYNU (0.62) | KYNUELANETRPM8ALDH1A1ALOX15 | |
| SCHEMBL21627154 | 0.85 | KYNU (0.59) | KYNUELANETRPM8ALDH1A1ALOX15 | |
| SCHEMBL29112134 | 0.85 | KYNU (0.56) | KYNUELANETRPM8ALDH1A1ALOX15 | |
| SCHEMBL846125 | 0.84 | CTRB1 (0.54) | KYNUELANECTRB1ATMPRTN3 | |
| SCHEMBL1239037 | 0.83 | KYNU (0.55) | KYNUELANETRPM8ALDH1A1ALOX15 | |
| SCHEMBL14981588 | 0.83 | ALDH1A1 (0.56) | KYNUELANETRPM8ALDH1A1ALOX15 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 8 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20170298097-A1 | Peptide Derivatives and Uses Thereof | NOSOPHARM (FR) | 2017-10-19 | — | — | US | disclosed |
| US-20170283434-A1 | NK1 ANTAGONISTS | OPKO HEALTH INC (US) | 2017-10-05 | — | — | US | disclosed |
| US-9688693-B2 | NK1 antagonists | OPKO HEALTH, INC. (US) | 2017-06-27 | — | — | US | disclosed |
| US-20140336158-A1 | NK1 ANTAGONISTS | TERSERA THERAPEUTICS LLC | 2014-11-13 | — | — | US | disclosed |
| US-8796299-B2 | NK1 antagonists | OPKO HEALTH, INC. (US) | 2014-08-05 | — | — | US | disclosed |
| US-20130023503-A1 | NK1 ANTAGONISTS | OPKO HEALTH, INC. (US) | 2013-01-24 | — | — | US | disclosed |
| US-8329935-B2 | Process for producing phosphorus-containing dehydroamino acid | MEJI SEIKA KAISHA LTD. (JP) | 2012-12-11 | — | — | US | disclosed |
| US-20110009662-A1 | PROCESS FOR PRODUCING PHOSPHORUS-CONTAINING DEHYDROAMINO ACID | MEIJI SEIKA KAISHA LTD. (JP) | 2011-01-13 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (5 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20170283434-A1 | NK1 ANTAGONISTS | HRH4, CRHR2, HRH2 | KYNU 416/4885ELANE 1476/4885TRPM8 723/4885 |
| US-20140336158-A1 | NK1 ANTAGONISTS | HRH4, CRHR2, HRH2 | KYNU 416/4885ELANE 1476/4885TRPM8 723/4885 |
| US-20130023503-A1 | NK1 ANTAGONISTS | HRH4, CRHR2, HRH2 | KYNU 416/4885ELANE 1476/4885TRPM8 723/4885 |
| US-20110009662-A1 | PROCESS FOR PRODUCING PHOSPHORUS-CONTAINING DEHYDROAMINO ACID | AMPD2, AMPD1, AMPD3 | KYNU 3432/4885ELANE 4828/4885TRPM8 4511/4885 |
| US-20170298097-A1 | Peptide Derivatives and Uses Thereof | VIP, IAPP, NGLY1 | KYNU 2575/4885ELANE 375/4885TRPM8 4227/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.